| 1. |
- Fissolo, N., et al.
(författare)
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Serum biomarker levels predict disability progression in patients with primary progressive multiple sclerosis
- 2024
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Ingår i: Journal of Neurology Neurosurgery and Psychiatry. - 0022-3050. ; 95:5, s. 410-418
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundWe aimed to investigate the potential of serum biomarker levels to predict disability progression in a multicentric real-world cohort of patients with primary progressive multiple sclerosis (PPMS).MethodsA total of 141 patients with PPMS from 18 European MS centres were included. Disability progression was investigated using change in Expanded Disability Status Scale (EDSS) score over three time intervals: baseline to 2 years, 6 years and to the last follow-up. Serum levels of neurofilament light chain (sNfL), glial fibrillar acidic protein (sGFAP) and chitinase 3-like 1 (sCHI3L1) were measured using single-molecule array assays at baseline. Correlations between biomarker levels, and between biomarkers and age were quantified using Spearman's r. Univariable and multivariable linear models were performed to assess associations between biomarker levels and EDSS change over the different time periods.ResultsMedian (IQR) age of patients was 52.9 (46.4-58.5) years, and 58 (41.1%) were men. Median follow-up time was 9.1 (7.0-12.6) years. Only 8 (5.7%) patients received treatment during follow-up. sNfL and sGFAP levels were moderately correlated (r=0.43) and both weakly correlated with sCHI3L1 levels (r=0.19 and r=0.17, respectively). In multivariable analyses, levels of the three biomarkers were associated with EDSS changes across all time periods. However, when analysis was restricted to non-inflammatory patients according to clinical and radiological parameters (n=64), only sCHI3L1 levels remained associated with future EDSS change.ConclusionsLevels of sNfL, sGFAP and sCHI3L1 are prognostic biomarkers associated with disability progression in patients with PPMS, being CHI3L1 findings less dependent on the inflammatory component associated with disease progression.
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| 2. |
- Mañé-Martínez, M. A., et al.
(författare)
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Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis
- 2016
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Ingår i: Journal of Neuroimmunology. - : Elsevier BV. - 0165-5728. ; 299, s. 112-117
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Tidskriftsartikel (refereegranskat)abstract
- In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients. © 2016 Elsevier B.V.
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| 3. |
- Ramos Riesco, M., et al.
(författare)
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Study of the Polymorphism in Copper(II) Decanoate through Its Phase Diagram with Decanoic Acid, and Texture of the Columnar Thermotropic Liquid Crystal Developable Domains in This and Similar Systems
- 2015
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Ingår i: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 15:1, s. 497-509
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Tidskriftsartikel (refereegranskat)abstract
- A new third polymorph of copper(II) decanoate has been found by two methods: from the crystallization of the saltacid solution and from a specific thermal treatment of the polymorph obtained in n-heptane. The new polymorph, whose crystal structure has been solved for the first time, is the most stable from the thermodynamic point of view. It presents a bilayer structure, but with two different types of paddle-wheels catenae with opposite orientations. This polymorphism as well as the temperature vs composition phase diagram of the system, [(1 - x) C9H21CO2H + (x) (C9H21CO2)(2)Cu], were solved by differential scanning calorimetry, Fourier transform infrared spectroscopy, X-ray diffraction, pair distribution function, and optical microscopy. The singularities of the phase diagram are (a) a Krafft-like process of molecular association of the copper(II) decanoate into the acid solution, at about T = 361.5 K and x = 0.022 (forming salt-acid adducts of 1:1 stoichiometry); (b) a fusion transition as an invariant (T = 379.1 K) of the solid salt in excess from the copper(II) decanoate crystal phase to the discotic liquid crystal, forming homeotropic developable domains (seen for the first time in these systems) of the pure salt into the saturated acid solution. These domains are seen not only in the copper(II) decanoate but also in other members of the series, at high salt concentration in the corresponding acid solution, and allow identification of the hexagonal columnar discotic structure of the mesophase (with the exception of the copper(II) butanoate, where the tetragonal domains with tilted disks, paddle-wheels, were seen in the same salt-acid region).
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| 4. |
- Alonso Magdalena, Lucia, et al.
(författare)
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Anticipation of age at onset in multiple sclerosis: methodologic pitfalls
- 2010
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 1600-0404 .- 0001-6314. ; 121:6, s. 426-428
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Background/aim - There are several reports that claim anticipation in complex or polygenic diseases such as multiple sclerosis (MS), Crohn disease or schizophrenia. The aim of the present study was to assess age at onset of MS during the last 60 years in the region of Costa de Ponent (Barcelona, Spain) showing how apparent changes in age at onset between generations can be an artefact of analysis based on cohorts that have not been followed enough time. Methods - The study comprised 1100 patients diagnosed of MS. The method used to correct for follow-up time bias involves constructing comparison cohorts that had been observed for the same amount of time. To ensure equal follow-up times, we restricted our analysis to patients whose onset was by 37 years of age (percentile 75) and were at least 37 years old. We analysed differences in age at onset using log-rank test to compare survival curves estimated by Kaplan-Meier method. Results - Age at onset decreases progressively from older to younger generations. However, when adjustment to equal follow-up time was done, anticipation in age at onset was not found. Conclusion - Anticipation of age at onset is undetectable when adjusted for follow-up time.
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