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Sökning: WFRF:(Masaki K) > (2015-2019)

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  • Hibar, Derrek P., et al. (författare)
  • Novel genetic loci associated with hippocampal volume
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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  • Magnusson, Joel, 1991, et al. (författare)
  • Multiple colliding laser pulses as a basis for studying high-field high-energy physics
  • 2019
  • Ingår i: Physical Review A - Atomic, Molecular, and Optical Physics. - 2469-9926 .- 2469-9934. ; 100:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Apart from maximizing the strength of optical electromagnetic fields achievable at high-intensity laser facilities, the collision of several phase-matched laser pulses has been identified theoretically as a trigger of and way to study various phenomena. These range from the basic processes of strong-field quantum electrodynamics to the extraordinary dynamics of the generated electron-positron plasmas. This has paved the way for several experimental proposals aimed at both fundamental studies of matter at extreme conditions and the creation of particle and radiation sources. Because of the unprecedented capabilities of such sources, they have the potential to open up new opportunities for experimental studies in nuclear and quark-gluon physics. We perform here a systematic analysis of different regimes and opportunities achievable with the concept of multiple colliding laser pulses, for both current and upcoming laser facilities. We reveal that several distinct regimes could be within reach of multi-petawatt laser facilities.
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