| 1. |
- Wang, Haidong, et al.
(författare)
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Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013
- 2014
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 384:9947, s. 957-979
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Remarkable financial and political efforts have been focused on the reduction of child mortality during the past few decades. Timely measurements of levels and trends in under-5 mortality are important to assess progress towards the Millennium Development Goal 4 (MDG 4) target of reduction of child mortality by two thirds from 1990 to 2015, and to identify models of success.METHODS: We generated updated estimates of child mortality in early neonatal (age 0-6 days), late neonatal (7-28 days), postneonatal (29-364 days), childhood (1-4 years), and under-5 (0-4 years) age groups for 188 countries from 1970 to 2013, with more than 29 000 survey, census, vital registration, and sample registration datapoints. We used Gaussian process regression with adjustments for bias and non-sampling error to synthesise the data for under-5 mortality for each country, and a separate model to estimate mortality for more detailed age groups. We used explanatory mixed effects regression models to assess the association between under-5 mortality and income per person, maternal education, HIV child death rates, secular shifts, and other factors. To quantify the contribution of these different factors and birth numbers to the change in numbers of deaths in under-5 age groups from 1990 to 2013, we used Shapley decomposition. We used estimated rates of change between 2000 and 2013 to construct under-5 mortality rate scenarios out to 2030.FINDINGS: We estimated that 6·3 million (95% UI 6·0-6·6) children under-5 died in 2013, a 64% reduction from 17·6 million (17·1-18·1) in 1970. In 2013, child mortality rates ranged from 152·5 per 1000 livebirths (130·6-177·4) in Guinea-Bissau to 2·3 (1·8-2·9) per 1000 in Singapore. The annualised rates of change from 1990 to 2013 ranged from -6·8% to 0·1%. 99 of 188 countries, including 43 of 48 countries in sub-Saharan Africa, had faster decreases in child mortality during 2000-13 than during 1990-2000. In 2013, neonatal deaths accounted for 41·6% of under-5 deaths compared with 37·4% in 1990. Compared with 1990, in 2013, rising numbers of births, especially in sub-Saharan Africa, led to 1·4 million more child deaths, and rising income per person and maternal education led to 0·9 million and 2·2 million fewer deaths, respectively. Changes in secular trends led to 4·2 million fewer deaths. Unexplained factors accounted for only -1% of the change in child deaths. In 30 developing countries, decreases since 2000 have been faster than predicted attributable to income, education, and secular shift alone.INTERPRETATION: Only 27 developing countries are expected to achieve MDG 4. Decreases since 2000 in under-5 mortality rates are accelerating in many developing countries, especially in sub-Saharan Africa. The Millennium Declaration and increased development assistance for health might have been a factor in faster decreases in some developing countries. Without further accelerated progress, many countries in west and central Africa will still have high levels of under-5 mortality in 2030.
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| 2. |
- Antoniou, Antonis C., et al.
(författare)
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Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
- 2011
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 20:16, s. 3304-3321
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Tidskriftsartikel (refereegranskat)abstract
- Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [ hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 x 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 x 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02-1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92-1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women.
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| 3. |
- Arnalds, Unnar B., et al.
(författare)
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Thermal transitions in nano-patterned XY-magnets
- 2014
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 105:4, s. 042409-
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Tidskriftsartikel (refereegranskat)abstract
- We have fabricated ultra-thin disc shaped islands wherein shape anisotropy confines the moment to the island plane, creating XY-like superspins. At low temperatures, the superspins are blocked, and, as the temperature is increased, they undergo a transition into a superparamagnetic state. The onset of this dynamic superspin state scales with the diameter of the islands, and it persists up to a temperature governed by the intrinsic ordering temperature of the island material defining a range in temperature in which dynamic behavior of the magnetic islands can be obtained.
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| 4. |
- Bandopadhayay, Pratiti, et al.
(författare)
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BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma
- 2014
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Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 20:4, s. 912-925
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Tidskriftsartikel (refereegranskat)abstract
- Purpose:MYC-amplified medulloblastomas are highly lethal tumors. Bromodomain and extraterminal (BET) bromodomain inhibition has recently been shown to suppress MYC-associated transcriptional activity in other cancers. The compound JQ1 inhibits BET bromodomain-containing proteins, including BRD4. Here, we investigate BET bromodomain targeting for the treatment of MYC-amplified medulloblastoma.Experimental Design:We evaluated the effects of genetic and pharmacologic inhibition of BET bromodomains on proliferation, cell cycle, and apoptosis in established and newly generated patient- and genetically engineered mouse model (GEMM)-derived medulloblastoma cell lines and xenografts that harbored amplifications of MYC or MYCN. We also assessed the effect of JQ1 on MYC expression and global MYC-associated transcriptional activity. We assessed the in vivo efficacy of JQ1 in orthotopic xenografts established in immunocompromised mice.Results:Treatment of MYC-amplified medulloblastoma cells with JQ1 decreased cell viability associated with arrest at G1 and apoptosis. We observed downregulation of MYC expression and confirmed the inhibition of MYC-associated transcriptional targets. The exogenous expression of MYC from a retroviral promoter reduced the effect of JQ1 on cell viability, suggesting that attenuated levels of MYC contribute to the functional effects of JQ1. JQ1 significantly prolonged the survival of orthotopic xenograft models of MYC-amplified medulloblastoma (P < 0.001). Xenografts harvested from mice after five doses of JQ1 had reduced the expression of MYC mRNA and a reduced proliferative index.Conclusion:JQ1 suppresses MYC expression and MYC-associated transcriptional activity in medulloblastomas, resulting in an overall decrease in medulloblastoma cell viability. These preclinical findings highlight the promise of BET bromodomain inhibitors as novel agents for MYC-amplified medulloblastoma.
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| 5. |
- Jafri, Syed M.A.H., et al.
(författare)
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Customizable Compression Architecture for Efficient Configuration in CGRAs
- 2011
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Ingår i: Proceedings. ; , s. 31-31
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Konferensbidrag (refereegranskat)abstract
- Today, Coarse Grained Reconfigurable Architectures (CGRAs) host multiple applications. Novel CGRAs allow each application to exploit runtime parallelism and time sharing. Although these features enhance the power and silicon efficiency, they significantly increase the configuration memory overheads. As a solution to this problem researchers have employed statistical compression, intermediate compact representation, and multicasting. Each of these techniques has different properties, and is therefore best suited for a particular class of applications. However, existing research only deals with these methods separately. In this paper we propose a morphable compression architecture that interleaves these techniques in a unique platform.
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| 6. |
- Jafri, Syed M. A. H., et al.
(författare)
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Morphable Compression Architecture for Efficient Configuration in CGRAs
- 2014
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Ingår i: 2014 17th Euromicro Conference on Digital System Design (DSD). ; , s. 42-49
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Konferensbidrag (refereegranskat)abstract
- Today, Coarse Grained Reconfigurable Architectures (CGRAs) host multiple applications. Novel CGRAs allow each application to exploit runtime parallelism and time sharing. Although these features enhance the power and silicon efficiency, they significantly increase the configuration memory overheads (up to 50% area of the overall platform). As a solution to this problem researchers have employed statistical compression, intermediate compact representation, and multicasting. Each of these techniques has different properties (i.e. compression ratio and decoding time), and is therefore best suited for a particular class of applications (and situation). However, existing research only deals with these methods separately. In this paper we propose a morphable compression architecture that interleaves these techniques in a unique platform. The proposed architecture allows each application to enjoy a separate compression/decompression hierarchy (consisting of various types and implementations of hardware/software decoders) tailored to its needs. Thereby, our solution offers minimal memory while meeting the required configuration deadlines. Simulation results, using different applications (FFT, Matrix multiplication, and WLAN), reveal that the choice of compression hierarchy has a significant impact on compression ratio (from configware replication to 52%) and configuration cycles (from 33 nsec to 1.5 secs) for the tested applications. Synthesis results reveal that introducing adaptivity incurs negligible additional overheads (1%) compared to the overall platform area.
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| 7. |
- Pourrahimi, Amir Masoud, et al.
(författare)
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Water-based synthesis and cleaning methods for high purity ZnO nanoparticles - comparing acetate, chloride, sulphate and nitrate zinc salt precursors
- 2014
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 4:67, s. 35568-35577
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Tidskriftsartikel (refereegranskat)abstract
- A low temperature (60 degrees C) aqueous synthesis method of high purity ZnO nanoparticles intended as fillers for ultra-low electrical conductivity insulations is described. Particles were prepared under identical conditions from different zinc salts based on nitrate, chloride, sulphate or acetate to compare their abilities to form high yields of sub-50 nm particles with narrow size distribution. The acetate salt gave uniform 25 nm ZnO particles with a conical prism shape. The chloride and sulphate derived particles showed mixed morphologies of nanoprisms and submicron petals, whereas the nitrate salt yielded prisms assembled into well-defined flower shapes with spiky edges. The micron-sized flower shapes were confirmed by Xray diffraction to consist of the smaller prism units. Photoluminescence spectroscopy showed emission in the blue-violet region with little variation depending on precursor salt, suggesting that the spectra were dependent on the primary nanoprism formation and rather independent of the final particle morphology. Microscopy revealed that the salt residuals after the reaction showed different affinity to the particle surfaces depending on the type of salt used, with the acetate creating ca. 20 nm thick hydrated shells; and in falling order of affinity: chloride, sulphate and nitrate. An acetate ion shielding effect during the synthesis was therefore assumed, preventing nanoparticle fusion during growth. Varying the concentrations of the counter-ions confirmed the shielding and only the acetate anions showed an ability to stabilize solitary nanoprisms formation in reaction yields from 2 to 10 g L-1. Ultrasonic particle surface cleaning was significantly more efficient than water replacement, resulting in a stable aqueous dispersion with a high zeta potential of 38.9 mV at pH 8.
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| 8. |
- Rezaei, A., et al.
(författare)
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HiWA : A hierarchical Wireless Network-on-Chip architecture
- 2014
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Ingår i: Proceedings of the 2014 International Conference on High Performance Computing and Simulation, HPCS 2014. - 9781479953127 ; , s. 499-505
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Konferensbidrag (refereegranskat)abstract
- Due to high latency and high power consumption in long hops between operational cores of NoCs, the performance of such architectures has been limited. In order to fill the gap between computing requirements and efficient communications, a new technology called Wireless Network-on-Chip (WNoC) has been emerged. Employing wireless communication links between cores, the new technology has reasonably increased the performance of NoC. However, wireless transceivers along with associated antenna impose considerable area and power overheads in WNoCs. Thus, in this paper, we introduce a hierarchical WNoC called Hierarchical Wireless-based Architecture (HiWA) to use the wireless resources optimally. In the proposed approach the network is divided into subnets where intra-subnet nodes communicate through wire links while inter-subnet communications are almost handled by single-hop wireless links. On top of that, we have also defined performance evaluation parameters. Simulation results show that the proposed architecture reduces average packet latency 16% and power consumption 14% in comparison with its conventional counterparts.
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| 9. |
- Zandira, Masoud, 1983, et al.
(författare)
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Fracture Characteristics of Austempered Spheroidal Graphite Aluminum Cast Irons
- 2010
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Ingår i: Journal of Iron and Steel Research International. - 1006-706X. ; 17:2, s. 31-35
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Tidskriftsartikel (refereegranskat)abstract
- The fracture characteristics of austempered spheroidal graphite aluminum cast iron had been investigated. The chemical content of the alloy was C3.2, Al2.2, Ni0.8 and Mg0.05 (in mass percent, %). Impact test samples were produced from keel blocks cast in CO2 molding process. The oversized impact samples were austenitized at 850 and 950 degrees C for 2 h followed by austempering at 300 and 400 degrees C for 30, 60, 120 and 180 min. The austempered samples were machined and tested at room temperature. The impact strength values for those samples austempered at 400 degrees C varied between 90 and 110J. Lower bainitic structures showed impact strength values of 22 to 50J. The fractures of the samples were examined using SEM. The results showed that the upper bainitic fracture revealed a honey Comb-like topography, which confirmed the ductile fracture behavior. The lower bainitic fractures of those samples austempered for short times revealed brittle fracture.
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