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- Pereira, H. A., et al.
(författare)
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Capacitor voltage balance performance comparison of MMC-STATCOM using NLC and PS-PWM strategies during negative sequence current injection
- 2016
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Ingår i: 18th European Conference on Power Electronics and Applications, EPE 2016 ECCE Europe, Karlsruhe, Germany, 5-9 September 2016. - 2325-0313. - 9789075815245
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Konferensbidrag (refereegranskat)abstract
- This paper addresses the modular multilevel converter applied as a static synchronous compensator. The main objective of this work is to compare the converter performance considering two different submodule capacitor voltage balancing strategies: nearest level control and phase-shifted pulse width modulation, during positive and negative sequence current injection. Results of a 15 MVA MMC STATCOM show that the nearest level control strategy has lower average switching frequency compared to the phase-shifted pulse width modulation strategy, considering comparable submodule capacitance voltage ripple.
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- Playdon, Mary C., et al.
(författare)
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Metabolomics Analytics Workflow for Epidemiological Research : Perspectives from the Consortium of Metabolomics Studies (COMETS)
- 2019
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Ingår i: Metabolites. - : MDPI. - 2218-1989 .- 2218-1989. ; 9:7
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Tidskriftsartikel (refereegranskat)abstract
- The application of metabolomics technology to epidemiological studies is emerging as a new approach to elucidate disease etiology and for biomarker discovery. However, analysis of metabolomics data is complex and there is an urgent need for the standardization of analysis workflow and reporting of study findings. To inform the development of such guidelines, we conducted a survey of 47 cohort representatives from the Consortium of Metabolomics Studies (COMETS) to gain insights into the current strategies and procedures used for analyzing metabolomics data in epidemiological studies worldwide. The results indicated a variety of applied analytical strategies, from biospecimen and data pre-processing and quality control to statistical analysis and reporting of study findings. These strategies included methods commonly used within the metabolomics community and applied in epidemiological research, as well as novel approaches to pre-processing pipelines and data analysis. To help with these discrepancies, we propose use of open-source initiatives such as the online web-based tool COMETS Analytics, which includes helpful tools to guide analytical workflow and the standardized reporting of findings from metabolomics analyses within epidemiological studies. Ultimately, this will improve the quality of statistical analyses, research findings, and study reproducibility.
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- Rejas, M., et al.
(författare)
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Performance comparison of phase shifted PWM and sorting method for modular multilevel converters
- 2015
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Ingår i: 17th European Conference on Power Electronics and Applications, EPE-ECCE Europe 2015, Geneva, Switzerland, 8-10 September. - 9789075815221
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Konferensbidrag (refereegranskat)abstract
- Modular Multilevel Converters (MMC) are the solution of preference in HVDC applications due to modularity, scalability, low losses and low filtering requirement. Carrier-based (PWM) and carrier-less (nearest level control) modulation can be applied. By using advanced sorting methods focusing on keeping the capacitor voltage ripple under some limit, unnecessary switching events are eliminated leading to reduced switching losses. This paper presents a comparison between the steady-state performances in terms of output voltage THD and equivalent switching frequency of the Phase Shifted Carrier PWM and NLC plus sorting methods.
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- Adori, Csaba, et al.
(författare)
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Exploring the role of neuropeptide S in the regulation of arousal : a functional anatomical study
- 2016
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Ingår i: Brain Structure and Function. - : Springer. - 1863-2653 .- 1863-2661. ; 221:7, s. 3521-3546
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Tidskriftsartikel (refereegranskat)abstract
- Neuropeptide S (NPS) is a regulatory peptide expressed by limited number of neurons in the brainstem. The simultaneous anxiolytic and arousal-promoting effect of NPS suggests an involvement in mood control and vigilance, making the NPS-NPS receptor system an interesting potential drug target. Here we examined, in detail, the distribution of NPS-immunoreactive (IR) fiber arborizations in brain regions of rat known to be involved in the regulation of sleep and arousal. Such nerve terminals were frequently apposed to GABAergic/galaninergic neurons in the ventro-lateral preoptic area (VLPO) and to tyrosine hydroxylase-IR neurons in all hypothalamic/thalamic dopamine cell groups. Then we applied the single platform-on-water (mainly REM) sleep deprivation method to study the functional role of NPS in the regulation of arousal. Of the three pontine NPS cell clusters, the NPS transcript levels were increased only in the peri-coerulear group in sleep-deprived animals, but not in stress controls. The density of NPS-IR fibers was significantly decreased in the median preoptic nucleus-VLPO region after the sleep deprivation, while radioimmunoassay and mass spectrometry measurements showed a parallel increase of NPS in the anterior hypothalamus. The expression of the NPS receptor was, however, not altered in the VLPO-region. The present results suggest a selective activation of one of the three NPS-expressing neuron clusters as well as release of NPS in distinct forebrain regions after sleep deprivation. Taken together, our results emphasize a role of the peri-coerulear cluster in the modulation of arousal, and the importance of preoptic area for the action of NPS on arousal and sleep.
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