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| 2. |
- Ongena, J., et al.
(författare)
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Recent progress on JET towards the ITER reference mode of operation at high density
- 2001
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Ingår i: Plasma Physics and Controlled Fusion. - 0741-3335 .- 1361-6587. ; 43, s. A11-A30
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Tidskriftsartikel (refereegranskat)abstract
- Recent progress towards obtaining high density and high confinement in JET as required for the ITER reference scenario at Q = 10 is summarized. Plasmas with simultaneous confinement H-98(y.2) = 1 and densities up to n/n(Gw) similar to 1 are now routinely obtained. This has been possible (i) by using plasmas at high (delta similar to 0.5) and medium (delta similar to 0.3-0.4) triangularity with sufficient heating power to maintain Type I ELMs, (ii) with impurity seeded plasmas at high (delta similar to 0.5) and low (delta less than or equal to 0.2) triangularity, (iii) with an optimized pellet injection sequence, maintaining the energy confinement and raising the density, and (iv) by carefully tuning the gas puff rate leading to plasmas with peaked density profiles and good confinement at long time scales. These high performance discharges exhibit Type I ELMs, with a new and more favourable behaviour observed at high densities, requiring further studies. Techniques for a possible mitigation of these ELMs are discussed, and first promising results are obtained with impurity seeding in discharges at high triangularity. Scaling studies using the new data of this year show a strong dependence of confinement on upper triangularity, density and proximity to the Greenwald limit. Observed MHD instabilities and methods to avoid these in high density and high confinement plasmas are discussed.
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| 3. |
- Hewett, D., et al.
(författare)
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Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map
- 2002
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Ingår i: Genomics. - : Elsevier BV. - 0888-7543 .- 0888-7543. ; 79:3, s. 305-14
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Tidskriftsartikel (refereegranskat)abstract
- Psoriasis is a chronic inflammatory disease of the skin with both genetic and environmental risk factors. Here we describe the creation of a single-nucleotide polymorphism (SNP) map spanning 900-1200 kb of chromosome 3q21, which had been previously recognized as containing a psoriasis susceptibility locus, PSORS5. We genotyped 644 individuals, from 195 Swedish psoriatic families, for 19 polymorphisms. Linkage disequilibrium (LD) between marker and disease was assessed using the transmission/disequilibrium test (TDT). In the TDT analysis, alleles of three of these SNPs showed significant association with disease (P<0.05). A 160-kb interval encompassing these three SNPs was sequenced, and a coding sequence consisting of 13 exons was identified. The predicted protein shares 30-40% homology with the family of cation/chloride cotransporters. A five-marker haplotype spanning the 3' half of this gene is associated with psoriasis to a P value of 3.8<10(-5). We have called this gene SLC12A8, coding for a member of the solute carrier family 12 proteins. It belongs to a class of genes that were previously unrecognized as playing a role in psoriasis pathogenesis.
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| 4. |
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| 5. |
- Loarte, A., et al.
(författare)
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Characterization of pedestal parameters and edge localized mode energy losses in the Joint European Torus and predictions for the International Thermonuclear Experimental Reactor
- 2004
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Ingår i: Physics of Plasmas. - : AIP Publishing. - 1070-664X .- 1089-7674. ; 11:5, s. 2668-2678
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the experimental characterization of pedestal parameters, edge localized mode (ELM) energy, and particle losses from the main plasma and the corresponding ELM energy fluxes on plasma facing components for a series of dedicated experiments in the Joint European Torus (JET). From these experiments, it is demonstrated that the simple hypothesis relating the peeling-ballooning linear instability to ELM energy losses is not valid. Contrary to previous observations at lower triangularities, small energy losses at low collisionality have been obtained in regimes at high plasma triangularity and q(95)similar to4.5, indicating that the edge plasma magnetohydrodynamic stability is linked with the transport mechanisms that lead to the loss of energy by conduction during type I ELMs. Measurements of the ELM energy fluxes on the divertor target show that their time scale is linked to the ion transport along the field and the formation of a high energy sheath, in agreement with kinetic modeling of ELMs. Higher density ELMs, of a convective nature, lead to overall much longer time scales for the ELM energy flux, with more than 80% of the ELM energy flux arriving after the surface divertor temperature has reached its maximum value. On the contrary, for low density ELMs, of a conductive nature, up to 40% of the energy flux arrives at the divertor target before the surface divertor temperature has reached its maximum value. These large and more conductive ELMs may lead to up to similar to50% of the ELM energy reaching the main wall plasma facing components instead of the divertor target. The extrapolation to the International Thermonuclear Experimental Reactor of the obtained results is described and the main uncertainties discussed.
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| 6. |
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| 7. |
- Steel, J, et al.
(författare)
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Pre-migration trauma and HIV-risk behavior
- 2003
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Ingår i: Transcultural psychiatry. - : SAGE Publications. - 1363-4615 .- 1461-7471. ; 40:1, s. 91-108
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Tidskriftsartikel (refereegranskat)abstract
- This study examined the relationship between pre-migration trauma and HIV-risk behavior in refugees from sub-Saharan Africa. The sample comprised 122 persons who had emigrated from sub-Saharan Africa and were currently residing in Sweden. Qualitative methods including individual interviews, focus groups, and interviews with key informants addressed questions regarding trauma experience and HIV-risk behavior. A history of pre-migration trauma was found to be associated with HIV-risk behavior. According to the participants, symptoms associated with post-traumatic stress disorder, depression, adjustment disorder, and substance use mediated the relationship between pre-migration trauma and sexual risk behavior. In contrast, a minority of the participants who reported pre-migration trauma but not psychological sequelae, or experienced post-traumatic growth, reported safer sexual practices. It appears that for some individuals, pre-migration trauma resulted in psychiatric sequelae, which may increase an individual's risk to be infected with HIV. Interventions targeted at individuals at increased risk (i.e. pre-migration trauma with unresolved psychiatric symptomatology) may facilitate the prevention of HIV and other sexually transmitted diseases in this population. Integration of multiple psychosocial and health issues is recommended for comprehensive treatment and prevention programs.
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| 8. |
- West, MA, et al.
(författare)
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Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling
- 2004
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5687, s. 1153-1157
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Tidskriftsartikel (refereegranskat)abstract
- Microbial products are sensed through Toll-like receptors (TLRs) and trigger a program of dendritic cell (DC) maturation that enables DCs to activate T cells. Although an accepted hallmark of this response is eventual down-regulation of DC endocytic capacity, we show that TLR ligands first acutely stimulate antigen macropinocytosis, leading to enhanced presentation on class I and class II major histocompatibility complex molecules. Simultaneously, actin-rich podosomes disappear, which suggests a coordinated redeployment of actin to fuel endocytosis. These reciprocal changes are transient and require p38 and extracellular signal–regulated kinase activation. Thus, the DC actin cytoskeleton can be rapidly mobilized in response to innate immune stimuli to enhance antigen capture and presentation.
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