| 1. |
- Cestino, Joaquín, et al.
(författare)
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A perspective on path dependence processes : The role of knowledge integration and embeddedness in business model innovation dynamics
- 2015
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Konferensbidrag (refereegranskat)abstract
- In this paper we examine why strategy innovation is rare. We integrate the knowledge-based view of the firm and embeddedness of economic action to interpret the historic emergence, formation and current lock-in of legacy newspapers. We research the historic case of the provincial press in UK and the current case of a regional leading newspaper in Spain and analyze how, in an industrial context of relative simplicity and certainty, path dependent formation processes are led by knowledge integration mechanisms. We also suggest that in legacy provincial newspapers the formed path has become locked-in due to embeddedness mechanisms, insolating it from outside negative inputs and perpetuating today’s failing business model. Finally, in order to enhance the potential contributions of path dependence to theory and practice, this paper proposes that an observable outcome of strategic change is needed and offer, for this purpose, a refined conceptualization of strategy innovation based on business model studies. This provides some clues about what is needed for the current lock-in of regional newspapers to be eventually unlock.
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| 2. |
- Cestino, Joaquín, et al.
(författare)
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A perspective on path dependence processes : The role of knowledge integration in business model persistence dynamics in the provincial press in England
- 2016
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Ingår i: Journal of Media Business Studies. - : Taylor & Francis Group. - 1652-2354 .- 2376-2977. ; 13:1, s. 22-44
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Tidskriftsartikel (refereegranskat)abstract
- This paper examines why strategy innovation is rare in the regional news industry. It integrates the knowledge-based view of a firm, path-dependence theoretical perspective and the field of business model studies to interpret the historic emergence, formation, and current lock-in of legacy regional newspapers. The historic case of the provincial press in England is analysed to consider how, in an industrial context of relative simplicity and certainty, path-dependent formation processes are led by knowledge integration mechanisms.
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| 3. |
- Cestino, Joaquín, et al.
(författare)
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Cultural norms and path dependence in business model innovation dynamics : The case of legacy provincial newspapers
- 2015
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In this paper we examine why business model innovation is rare. We integrate the theoretical frameworks of embeddedness, path dependency and business models to interpret the historic emergence, formation and current lock-in of legacy provincial newspapers. We analyze the historic case of the provincial press in UK and the current case of a regional leading newspaper in Spain and suggest that the cultural norms which today configure the path dependent business model of legacy newspapers are historically contingent. We also propose that in legacy provincial newspapers the formed path has become locked in due to embeddedness mechanisms, isolating it from outside negative inputs and perpetuating today’s failing business model. Finally, we offer a conceptualization of lock-in from a business model innovation perspective which provide some clues about what is needed for the current lock-in of regional newspapers to be eventually unlock.
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| 4. |
- Huels, David J., et al.
(författare)
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E-cadherin can limit the transforming properties of activating beta-catenin mutations
- 2015
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Ingår i: EMBO Journal. - : EMBO. - 0261-4189 .- 1460-2075. ; 34:18, s. 2321-2333
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Tidskriftsartikel (refereegranskat)abstract
- Wnt pathway deregulation is a common characteristic of many cancers. Only colorectal cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of the pancreas) have activating mutations in beta-catenin (CTNNB1). We have compared the dynamics and the potency of beta-catenin mutations in vivo. Within the murine small intestine (SI), an activating mutation of beta-catenin took much longer to achieve Wnt deregulation and acquire a crypt-progenitor cell (CPC) phenotype than Apc or Gsk3 loss. Within the colon, a single activating mutation of beta-catenin was unable to drive Wnt deregulation or induce the CPC phenotype. This ability of beta-catenin mutation to differentially transform the SI versus the colon correlated with higher expression of E-cadherin and a higher number of E-cadherin: beta-catenin complexes at the membrane. Reduction in E-cadherin synergised with an activating mutation of beta-catenin resulting in a rapid CPC phenotype within the SI and colon. Thus, there is a threshold of beta-catenin that is required to drive transformation, and E-cadherin can act as a buffer to sequester mutated beta-catenin.
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