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| 2. |
- Eldh, Maria, 1980, et al.
(författare)
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MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma
- 2014
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Ingår i: BMC Cancer. - London : Springer Science and Business Media LLC. - 1471-2407. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- Uveal melanoma is a tumour arising from melanocytes of the eye, and 30 per cent of these patients develop liver metastases. Exosomes are small RNA containing nano-vesicles released by most cells, including malignant melanoma cells. This clinical translational study included patients undergoing isolated hepatic perfusion (IHP) for metastatic uveal melanoma, from whom exosomes were isolated directly from liver perfusates. The objective was to determine whether exosomes are present in the liver circulation, and to ascertain whether these may originate from melanoma cells.
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| 3. |
- Liss, Jan-Erik, et al.
(författare)
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Knubbved istället för vanlig ved? : slutrapport från projekt Styckeved för småskalig eldning
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Chunkwood is a wood fuel with a fuel particle length between 50 and 150 mm, i.e. with a size between wood chips and conventional firewood. Chunkwood can be produced and handled as rational as wood chips and can dry during storage like conventional firewood. This is known since long. In project Smallwood for small scale heating we have investigated if chunkwood can be used in a small scale as a fuel for heating detached houses in conventional firewood boilers as well as automatically fed to a boiler in a similar way as wood chips. We have also compared complete systems for small scale production, distribution and heating with chunkwood, wood chips and conventional firewood. Storage of chunkwood produced for testing small scale boilers confirmed that chunkwood can dry during storage at least as good as conventional firewood. Tests in different boilers for detached homes showed that chunkwood can be used in conventional firewood boilers as well as in automatically fed wood chips boilers. Chunkwood can be delivered to the customer to the same or lower cost as wood chips and firewood, but need much less handling by the customer than conventional firewood. However, if chunkwood is used in a conventional firewood boiler, it needs some handling by shovel and wheelbarrow. Technical development of handling from the storage to the boiler is needed. In a somewhat larger scale, e.g. a boiler for apartment blocks or a small district heating system, chunkwood should be very interesting as a replacement of fuel pellets or fuel briquettes. It would be interesting with some projects, which in this scale demonstrates the whole system from the forest to heat.
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| 4. |
- Mattsson, Niklas, 1979, et al.
(författare)
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Cerebrospinal Fluid Microglial Markers in Alzheimer's Disease: Elevated Chitotriosidase Activity but Lack of Diagnostic Utility
- 2011
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Ingår i: NeuroMolecular Medicine. - : Springer Science and Business Media LLC. - 1535-1084 .- 1559-1174. ; 13:2, s. 151-159
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Tidskriftsartikel (refereegranskat)abstract
- Activated microglial cells, which are the resident macrophages of the central nervous system, surround amyloid beta-plaques in Alzheimer's disease (AD) brains. Inflammation including microglial activation may contribute in AD pathogenesis, and biomarkers for this process may thus be of value to study AD pathogenesis and might facilitate development of therapies targeting these cells. We therefore examined cerebrospinal fluid (CSF) biomarkers in patients with AD, other dementias, mild cognitive impairment and in healthy controls. Samples were analyzed for markers with known association to macrophage activity, including chitotriosidase, YKL-40 (CHI3L1, HC gp-39) and chemokine CC motif ligand 2 (CCL2, MCP1). Patients with AD had higher chitotriosidase activity than controls and patients with stable mild cognitive impairment, consistent with the presence of activated microglial cells in AD brains, but with large overlaps between groups. CCL2 and YKL-40 concentrations did not differ among groups. Microglial markers are unlikely to be useful for AD diagnosis, but might be useful for identification of distinct subgroups of patients, and for the development and implementation of drugs targeting microglial pathology.
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| 5. |
- Prade, Thomas, et al.
(författare)
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Vall som biogassubstrat : utvärdering av skördesystemets och odlingsintensitetens påverkan på biogasutbytet
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I ett fältförsök på marginalmark odlades och skördades olika vallblandningar som biogassubstrat. Syftet med studien var att (a) undersöka biomassa- och metanavkastningen för de olika vallblandningarna och (b) analysera spridningen av metanpotentialbestämningarnas resultat för att undersöka möjligheter till minskning av analyskostnaderna genom annan provtagnings- och provberedningsstrategi. En gödslad kommersiell vall gav med 8,1 ton ts/ha den högsta biomassaavkastningen vid två skördar per år. Vid bara en skörd per år var det den gödslade kommersiella vallen och den befintliga vegetationen som gav högst biomassaavkastning. Metanpotentialsskillnaderna mellan vallblandningarna var ganska små vid samma skördetidpunkt. Däremot ökar den specifika metanpotentialen (liter metan per kg VS) med två skördar per år. Beräkningarna visade att antalet analyser för metanpotentialbestämningen kan reduceras betydligt när samlingsprover används i analyserna. På detta sätt minskar man variationen inom leden, vilket bidrar till att skillnader mellan olika behandlingar enklare kan upptäckas.
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| 6. |
- Andersson, Per, et al.
(författare)
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Cooperation and Competition during Evolution of Technology Based Service Innovation : The Case of Development of NFC Enabled Mobile Services in Nice
- 2013
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Ingår i: 12th International Conference on Mobile Business, ICMB 2013. - : Association for Information Systems.
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Konferensbidrag (refereegranskat)abstract
- Concurrent cooperation and competition is an important characteristic of innovation processes. We illustrate this with reference to a case on new mobile, NFC (Near Field Communications) based services: a systemic service innovation project in Nice, named Cityzi. Cityzi is a local sub-process in the globally dispersed efforts to develop and implement mobile services enabled by the NFC technique that can be used for mobile communication. The project requires cooperation, also between competing actors, to determine technical interfaces as well as development and implementation of business models for production and use of the services in practice. Due to the heterogeneity of resources that need to be combined, actors from different industrial as well as public policy sectors participate in the project. We apply a network perspective for our analysis of cooperation and competition during service innovation processes, specifically focusing on network overlapping processes. A dynamic conceptual model is suggested to capture the complexities of implementing largescale ICT infrastructure projects, when going from trial to commercialization.
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| 7. |
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| 8. |
- Andersson, Per, et al.
(författare)
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Global policy networks’ involvement in service innovation. Turning the mobile phone into a wallet by applying NFC technology
- 2011
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Ingår i: The IMP Journal. - 2059-1403 .- 0809-7259. ; 5:3, s. 193-211
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Tidskriftsartikel (refereegranskat)abstract
- The mobile phone attracts an increasing number of service applications enabled by technical developments. On-going efforts aim to widen the scope of mobile payments and “turning the mobile phone into a wallet” with the help of Near Field Technology (NFC). A number of industries are involved in this development. To enable large scale commercial application of the new technology for mobile payments, several global industry associations, what we label Global Policy Networks (GPNs), are involved in standard setting, certification, visions and promotion of business applications, etc. The purpose of the paper is to analyze the role of GPNs in establishing global policies to enable business actors to develop and implement local policies applying the new technology for business purposes. The paper focuses on how some yet to be settled global policy issues affect local policies.
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