| 1. |
- Hammar, Linus, 1979, et al.
(författare)
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Cumulative impact assessment for ecosystem-based marine spatial planning
- 2020
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 734
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Tidskriftsartikel (refereegranskat)abstract
- Claims for ocean space are growing while marine ecosystems suffer from centuries of insufficient care. Human pressures from runoff, atmospheric emissions, marine pollution, fishing, shipping, military operations and other activities wear on habitats and populations. Ecosystem-based marine spatial planning (MSP) has emerged worldwide as a strategic instrument for handling conflicting spatial claims among competing sectors and the environment. The twofold objective of both boosting the blue economy and protecting the environment is challenging in practice and marine planners need decision support. Cumulative Impact Assessment (CIA) was originally developed to provide an overview of the human imprint on the world's ocean ecosystems. We have now added a scenario component to the CIA model and used it within Swedish ecosystem-based MSP. This has allowed us to project environmental impacts for different planning alternatives throughout the planning process, strengthening the integration of environmental considerations into strategic decision-making. Every MSP decision may entail a local shift of environmental impact, causing positive or negative consequences for ecosystem components. The results from Swedish MSP in the North Sea and Baltic Sea illustrate that MSP certainly has the potential to lower net cumulative environmental impact, both locally and across sea basins, as long as environmental values are rated high and prevailing pressures derive from activities that are part of MSP. By synthesizing innumerous data into comprehensible decision support that informs marine planners of the likely environmental consequences of different options, CIA enables ecosystem-based MSP in practice.
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| 2. |
- Broman, K. K., et al.
(författare)
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Active surveillance of patients who have sentinel node positive melanoma: An international, multi-institution evaluation of adoption and early outcomes after the Multicenter Selective Lymphadenectomy trial II (MSLT-2)
- 2021
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Ingår i: Cancer. - : Wiley. - 0008-543X .- 1097-0142. ; 127:13, s. 2251-2261
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Tidskriftsartikel (refereegranskat)abstract
- Background For patients with sentinel lymph node (SLN)-positive cutaneous melanoma, the Second Multicenter Selective Lymphadenectomy trial demonstrated equivalent disease-specific survival (DSS) with active surveillance using nodal ultrasound versus completion lymph node dissection (CLND). Adoption and outcomes of active surveillance in clinical practice and in adjuvant therapy recipients are unknown. Methods In a retrospective cohort of SLN-positive adults treated at 21 institutions in Australia, Europe, and the United States from June 2017 to November 2019, the authors evaluated the impact of active surveillance and adjuvant therapy on all-site recurrence-free survival (RFS), isolated nodal RFS, distant metastasis-free survival (DMFS), and DSS using Kaplan-Meier curves and Cox proportional hazard models. Results Among 6347 SLN biopsies, 1154 (18%) were positive and had initial negative distant staging. In total, 965 patients (84%) received active surveillance, 189 (16%) underwent CLND. Four hundred thirty-nine patients received adjuvant therapy (surveillance, 38%; CLND, 39%), with the majority (83%) receiving anti-PD-1 immunotherapy. After a median follow-up of 11 months, 220 patients developed recurrent disease (surveillance, 19%; CLND, 22%), and 24 died of melanoma (surveillance, 2%; CLND, 4%). Sixty-eight patients had an isolated nodal recurrence (surveillance, 6%; CLND, 4%). In patients who received adjuvant treatment without undergoing prior CLND, all isolated nodal recurrences were resectable. On risk-adjusted multivariable analyses, CLND was associated with improved isolated nodal RFS (hazard ratio [HR], 0.36; 95% CI, 0.15-0.88), but not all-site RFS (HR, 0.68; 95% CI, 0.45-1.02). Adjuvant therapy improved all-site RFS (HR, 0.52; 95% CI, 0.47-0.57). DSS and DMFS did not differ by nodal management or adjuvant treatment. Conclusions Active surveillance has been adopted for most SLN-positive patients. At initial assessment, real-world outcomes align with randomized trial findings, including in adjuvant therapy recipients. Lay Summary For patients with melanoma of the skin and microscopic spread to lymph nodes, monitoring with ultrasound is an alternative to surgically removing the remaining lymph nodes. The authors studied adoption and real-world outcomes of ultrasound monitoring in over 1000 patients treated at 21 centers worldwide, finding that most patients now have ultrasounds instead of surgery. Although slightly more patients have cancer return in the lymph nodes with this strategy, typically, it can be removed with delayed surgery. Compared with up-front surgery, ultrasound monitoring results in the same overall risk of melanoma coming back at any location or of dying from melanoma.
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| 3. |
- Broman, K. K., et al.
(författare)
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Surveillance of Sentinel Node-Positive Melanoma Patients with Reasons for Exclusion from MSLT-II: Multi-Institutional Propensity Score Matched Analysis
- 2021
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Ingår i: Journal of the American College of Surgeons. - : Ovid Technologies (Wolters Kluwer Health). - 1072-7515. ; 232:4, s. 424-431
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In sentinel lymph node (SLN)-positive melanoma, two randomized trials demonstrated equivalent melanoma-specific survival with nodal surveillance vs completion lymph node dissection (CLND). Patients with microsatellites, extranodal extension (ENE) in the SLN, or >3 positive SLNs constitute a high-risk group largely excluded from the randomized trials, for whom appropriate management remains unknown. STUDY DESIGN: SLN-positive patients with any of the three high-risk features were identified from an international cohort. CLND patients were matched 1:1 with surveillance patients using propensity scores. Risk of any-site recurrence, SLN-basin-only recurrence, and melanoma specific mortality were compared. RESULTS: Among 1,154 SLN-positive patients, 166 had ENE, microsatellites, and/or >3 positive SLN. At 18.5 months median follow-up, 49% had recurrence (vs 26% in patients without high-risk features, p < 0.01). Among high-risk patients, 52 (31%) underwent CLND and 114 (69%) received surveillance. Fifty-one CLND patients were matched to 51 surveillance patients. The matched cohort was balanced on tumor, nodal, and adjuvant treatment factors. There were no significant differences in any-site recurrence (CLND 49%, surveillance 45%, p = 0.99), SLN-basin-only recurrence (CLND 6%, surveillance 14%, p = 0.20), or melanoma-specific mortality (CLND 14%, surveillance 12%, p = 0.86). CONCLUSIONS: SLN-positive patients with microsatellites, ENE, or >3 positive SLN constitute a high-risk group with a 2-fold greater recurrence risk. For those managed with nodal surveillance, SLN-basin recurrences were more frequent, but all-site recurrence and melanoma-specific mortality were comparable to patients treated with CLND. Most recurrences were outside the SLN-basin, supporting use of nodal surveillance for SLN-positive patients with microsatellites, ENE, and/or >3 positive SLN. Crown Copyright (C) 2020 Published by Elsevier Inc. on behalf of the American College of Surgeons. All rights reserved.
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| 4. |
- Do, Tan Manh
(författare)
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Excess pore water pressure generation in crushed and fine granular materials under cyclic traffic loads
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Excess pore water pressure can develop in subgrades of railway and pavement substructures due to cyclic loading from heavy traffic, leading to the migration of fine particles into upper layers. This migration can clog pores and diminish the drainage capacity of upper layers,negatively impacting the long-term performance of sub-structures and service life, ultimately risking failure. Therefore, understanding the mechanisms behind the accumulation of excess pore water pressures and the migration of fine particles under cyclic loading is essential for efficient and cost-effective maintenance methods. The main objectives of this research include (1) investigating excess pore water pressure generation in crushed and fine granular materials under cyclic loading, (2) evaluating the migration of these materials into upper layers under cyclic loading, and (3) simulating a practical application using an advanced model to provide valuable insights into the operation of structures subjected to cyclic traffic loads while considering real-world factors from the field.A series of cyclic triaxial tests were conducted to investigate the generation of excess pore water pressure in fine granular materials. Two types of fine granular materials, tailings (a crushed material) and railway sand (a fine granular material) were selected for this investigation. The cyclic characteristics of these materials, including cyclic axial strain and excess pore water pressure, were evaluated in terms of number of cycles and applied cyclics tress ratios (CSR). As a result, the cyclic axial strain and excess pore water pressure were observed to accumulate over time due to cyclic loading. However, the extent of accumulation was found to be significantly dependent on CSR values and material types. In addition, a relationship between excess pore water pressure and cyclic axial strain of the fine granular materials was established and proposed based on the results from the undrained cyclic triaxial tests (including both tailings and railway sand samples).To assess the migration of fine granular materials into overlying layers under cyclic loading, a modified large-scale triaxial system was employed as a physical model test. A quantitative analysis of material migration was based on the mass percentage and grain size of migrated materials collected at the gravel layer. Additionally, cyclic responses (strain and excess pore water pressure) were evaluated. As a result, the total migration rate of the tailing sample was significantly higher than that of the railway sand sample. The migration analysis on tailings also revealed that finer tailings particles exhibited a greater tendency to migrate into the upper gravel layer compared to coarser tailings particles under cyclic loading. This migration could be attributed to significant increases in excess pore water pressure during the final cycles of the physical model test. The findings from this research could make a valuable contribution to the existing literature concerning the accumulation of excess pore water pressure and its effects on the migration of fine particles under cyclic loading.A numerical study was conducted to simulate the complex interactions between tailings materials and cyclic traffic loads on the piers of tailings dams. The integration of experimental data and advanced constitutive models enabled a comprehensive understanding of the behavior of tailings under these loading conditions. The findings focused on the build-up of excess pore water pressures in tailings subjected to cyclic traffic loads while taking into account the effects of truck loads, velocities, and truck resting times. As a result, excess pore water pressures in tailings progressively increased with the number of passing trucks, indicating a cumulative effect of loading cycles. In addition, the effect of truck loads and truck velocities on the excess pore pressure build-up was discovered, with higher truck loads and lower truck velocities leading to increased excess pore pressures, posing a greater risk. Furthermore, through anoptimization process involving variations in truck loads, velocities, and resting times, it was revealed that a combination of increased truck velocity, reduced truck load, and extended truck resting time could effectively minimize the build-up of excess pore water pressures in tailings beneath the pier. These findings offer valuable guidance for optimizing transportation operations on tailings dam piers, enhancing efficiency and safety.
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| 5. |
- Do, Tan Manh, et al.
(författare)
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Excess pore water pressure generation in fine granular materials under undrained cyclic triaxial loading
- 2023
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Ingår i: International Journal of Geo-Engineering. - : Springer Nature. - 2198-2783. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Understanding the mechanism of excess pore water pressure generation in subgrades is essential for not only designing but also further maintenance purposes. The primary goal of this research was to investigate excess pore water pressure generation in fine granular materials under cyclic loading. A series of undrained cyclic triaxial tests were performed to study the excess pore water pressure generation in two selected fine granular materials: (1) railway sand and (2) tailings. The excess pore water pressure response of these materials was evaluated in terms of density conditions, number of cycles, and applied cyclic stress ratios (CSR). As a result, excess pore water pressure accumulated over time due to cyclic loading. However, its accumulation was significantly dependent on the governing factors, i.e., densities, CSR values, and material types. The excess pore water pressure exhibited a slight increase at low CSR values, but a sharp increase was observed at higher CSR values, which ultimately led to a failure state after a certain number of cycles. In addition, under the same loading conditions, the samples that had higher relative compaction showed better resistance to cyclic loads as compared to those with lower relative compaction. Finally, a relationship between excess pore water pressure and cyclic axial strain of the fine granular materials was discovered.
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| 6. |
- Do, Tan Manh, et al.
(författare)
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Migration of fine granular materials into overlying layers using a modified large-scale triaxial system
- 2024
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Ingår i: Geomechanics and Engineering. - : Techno-Press. - 2005-307X .- 2092-6219. ; 37:4, s. 359-370
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Tidskriftsartikel (refereegranskat)abstract
- The primary goal of this study is to evaluate the migration of fine granular materials into overlying layers under cyclic loading using a modified large-scale triaxial system as a physical model test. Samples prepared for the modified large-scale triaxial system comprised a 60 mm thick gravel layer overlying a 120 mm thick subgrade layer, which could be either tailings or railway sand. A quantitative analysis of the migration of fine granular materials was based on the mass percentage and grain size of migrated materials collected in the gravel. In addition, the cyclic characteristics, i.e., accumulated axial strain and excess pore water pressure, were evaluated. As a result, the total migration rate of the railway sand sample was found to be small. However, the total migration rate of the sample containing tailings in the subgrade layer was much higher than that of the railway sand sample. In addition, the migration analysis revealed that finer tailings particles tended to be migrated into the upper gravel layer easier than coarser tailings particles under cyclic loading. This could be involved in significant increases in excess pore water pressure at the last cycles of the physical model test.
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| 7. |
- Do, Tan Manh, et al.
(författare)
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Railway embankment behaviour due to increased axle loads - A numerical study
- 2021
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Ingår i: 18th Nordic Geotechnical Meeting 18-19 January 2021, Helsinki, Finland. - : Institute of Physics (IOP).
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Konferensbidrag (refereegranskat)abstract
- Due to an increase in axle loads, the development of excess pore water pressure and settlement in a railway track foundation of fine-grained subgrade soil can be observed. A thorough understanding of the mechanism of development of excess pore water pressure is essential for understanding the development of settlements and the design of potential ground improvement. In this paper, a three dimensional numerical study is presented, which investigates the effects of an increase in axle loads of trains on both excess pore water pressure and settlement. Special attention is given to a soft soil layer beneath the embankment and the influence of ground improvement (deep soil mixing columns). As a result, an increase in axle loads leads to a considerable increase in both excess pore pressures and settlement in the subgrade layer. This increase is more significant in the case of heavy axle load (32.5 tons) than that of the light axle load (16 tons). In addition, cyclic loading can lead to a considerable increase in both vertical displacements and excess pore water pressure. The use of deep soil mixing columns reduces excess pore water pressures and settlements significantly.
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| 8. |
- Do, Tan Manh, et al.
(författare)
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Tailings fluidization under cyclic triaxial loading – a laboratory study
- 2022
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Ingår i: Geomechanics and Engineering. - : Techno Press. - 2005-307X .- 2092-6219. ; 29:5, s. 497-508
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Tidskriftsartikel (refereegranskat)abstract
- Tailings fluidization (i.e., tailings behave as being fluidized) under cyclic loading is one concern during the construction of tailings dams, especially in the shallow tailings layers. The primary goal of this study is to evaluate the responses of tailings under cyclic loadings and the tailings potential for fluidization. A series of cyclic triaxial undrained and drained tests were performed on medium and dense tailings samples under various cyclic stress ratios (CSR). The results indicated that axial strain and excess pore water pressure accumulated over time due to cyclic loading. However, the accumulations were dependent on CSR values, densities, and drainage conditions. The fluidization potential analysis in this study was then evaluated based on the obtained cyclic axial strain and excess pore water pressure. As a result, tailings samples were stable (unfluidized) under small CSR values, and the critical CSR values, where the tailings fluidized, varied depending on the density of tailings samples. Tailings fluidization is triggered as cyclic stress ratios reach critical values. In this study, the critical CSR values were found to be 0.15 and 0.40 for medium and dense samples, respectively.
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| 9. |
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| 10. |
- Edsfeldt, Andreas, et al.
(författare)
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Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating
- 2021
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Ingår i: JACC: Basic to Translational Science. - : Elsevier BV. - 2452-302X. ; 6:9-10, s. 734-745
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Tidskriftsartikel (refereegranskat)abstract
- Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression.
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