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Sleep Patterns and ...
Sleep Patterns and the Risk of Acute Stroke Results From the INTERSTROKE International Case-Control Study
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Mc Carthy, C. E. (författare)
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Yusuf, S. (författare)
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Judge, C. (författare)
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Alvarez-Iglesias, A. (författare)
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Hankey, G. J. (författare)
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Oveisgharan, S. (författare)
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Damasceno, A. (författare)
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Iversen, H. K. (författare)
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- Rosengren, Annika, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Avezum, A. (författare)
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Lopez-Jaramillo, P. (författare)
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Xavier, D. (författare)
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Wang, X. (författare)
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Rangarajan, S. (författare)
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O'Donnell, M. (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Neurology. - 0028-3878. ; 100:21
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and ObjectivesSymptoms of sleep disturbance are common and may represent important modifiable risk factors of stroke. We evaluated the association between a spectrum of sleep disturbance symptoms and the risk of acute stroke in an international setting.MethodsThe INTERSTROKE study is an international case-control study of patients presenting with first acute stroke and controls matched by age (+/- 5 years) and sex. Sleep symptoms in the previous month were assessed through a questionnaire. Conditional logistic regression estimated the association between sleep disturbance symptoms and acute stroke, expressed as odds ratios (ORs) and 95% CIs. The primary model adjusted for age, occupation, marital status, and modified Rankin scale at baseline, with subsequent models adjusting for potential mediators (behavioral/disease risk factors).ResultsOverall, 4,496 matched participants were included, with 1,799 of them having experienced an ischemic stroke and 439 an intracerebral hemorrhage. Short sleep (<5 hours: OR 3.15, 95% CI 2.09-4.76), long sleep (>9 hours: OR 2.67, 95% CI 1.89-3.78), impaired quality (OR 1.52, 95% CI 1.32-1.75), difficulty getting to sleep (OR 1.32, 95% CI 1.13-1.55) or maintaining sleep (OR 1.33, 95% CI 1.15-1.53), unplanned napping (OR 1.48, 95% CI 1.20-1.84), prolonged napping (>1 hour: OR 1.88, 95% CI 1.49-2.38), snoring (OR 1.91, 95% CI 1.62-2.24), snorting (OR 2.64, 95% CI 2.17-3.20), and breathing cessation (OR 2.87, 95% CI 2.28-3.60) were all significantly associated with an increased odds of acute stroke in the primary model. A derived obstructive sleep apnea score of 2-3 (2.67, 2.25-3.15) and cumulative sleep symptoms (>5: 5.38, 4.03-7.18) were also associated with a significantly increased odds of acute stroke, with the latter showing a graded association. After an extensive adjustment, significance was maintained for most of the symptoms (not difficulty getting to/maintaining sleep and unplanned napping), with similar findings for stroke subtypes.DiscussionWe found that sleep disturbance symptoms were common and associated with a graded increased risk of stroke. These symptoms may be a marker of increased individual risk or represent independent risk factors. Future clinical trials are warranted to determine the efficacy of sleep interventions in stroke prevention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- cardiovascular-disease
- insomnia symptoms
- mortality
- duration
- metaanalysis
- events
- adults
- Neurosciences & Neurology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mc Carthy, C. E.
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Yusuf, S.
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Judge, C.
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Alvarez-Iglesias ...
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Hankey, G. J.
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Oveisgharan, S.
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visa fler...
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Damasceno, A.
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Iversen, H. K.
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Rosengren, Annik ...
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Avezum, A.
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Lopez-Jaramillo, ...
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Xavier, D.
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Wang, X.
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Rangarajan, S.
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O'Donnell, M.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Neurology
- Av lärosätet
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Göteborgs universitet