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- Noz, Marilyn E., et al.
(författare)
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An integrated approach to biodistribution radiation absorbed dose estimates
- 1993
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Ingår i: European Journal of Nuclear Medicine. - 0340-6997 .- 1432-105X. ; 20:2, s. 165-169
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Tidskriftsartikel (refereegranskat)abstract
- An integrated approach to existing methods of extracting biodistribution data, pharmacokinetics and radiation absorbed dose estimates from serial scintigraphic images is described. This approach employs a single computer-generated user interface to reformat planar scans into a standard file type, align conjugate (anterior and posterior) images, draw regions of interest {(ROIs)} over selected organs and lesions and generate count data for anterior and posterior views and calculated geometric means. Using standard correction methods, the fraction injected activity is obtained for all {ROIs} and total body. This methodology has been applied to the analysis of {indium-III-labelled} breast-cancer-directed antibodies and technetium-90m-labelled {CEA-specific} antibody fragments in non-small-cell lung cancer. It is anticipated that this approach will be useful for evaluating the dosimetry of other radiolabelled monoclonal antibodies, as well as other radiopharmaceuticals.}
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