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- Arking, D. E., et al.
(författare)
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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
- 2014
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 46:8, s. 826-836
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Tidskriftsartikel (refereegranskat)abstract
- The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼ 8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD. © 2014 Nature America, Inc.
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| 3. |
- De Medeiros, J. R., et al.
(författare)
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Overview of semi-sinusoidal stellar variability with the CoRoT satellite
- 2013
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 555, s. A63-
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Tidskriftsartikel (refereegranskat)abstract
- Context. To date, the CoRoT space mission has produced more than 124 471 light curves. Classifying these curves in terms of unambiguous variability behavior is mandatory for obtaining an unbiased statistical view on their controlling root-causes. Aims. The present study provides an overview of semi-sinusoidal light curves observed by the CoRoT exo-field CCDs. Methods. We selected a sample of 4206 light curves presenting well-defined semi-sinusoidal signatures. The variability periods were computed based on Lomb-Scargle periodograms, harmonic fits, and visual inspection. Results. Color-period diagrams for the present sample show the trend of an increase of the variability periods as long as the stars evolve. This evolutionary behavior is also noticed when comparing the period distribution in the Galactic center and anti-center directions. These aspects indicate a compatibility with stellar rotation, although more information is needed to confirm their root-causes. Considering this possibility, we identified a subset of three Sun-like candidates by their photometric period. Finally, the variability period versus color diagram behavior was found to be highly dependent on the reddening correction.
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| 5. |
- Madureira, H. M. G., et al.
(författare)
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System-level power consumption modeling of a SoC for WSN applications
- 2011
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Ingår i: Proceedings - 2011 IEEE 2nd International Conference on Networked Embedded Systems for Enterprise Applications.
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Konferensbidrag (refereegranskat)abstract
- Energy consumption is a critical issue for wireless sensor networks (WSN) because of the limited energy supply on the nodes. Therefore, performance evaluation is very important, especially at early stages of the design flow. In this work, we present the modeling and simulation of nodes composed by a typical system on chip (SoC) for WSN applications using SystemC/TLM. The SoC contains a MIPS-based processor, a memory, a bus, a timer, a transceiver and a battery. The model is intended to allow power estimation in WSN simulation. The battery module estimates the energy consumption of the node by computing the amount of electrical charge used by each block As a case study, we performed a star topology WSN simulation, showed the power consumption of each node, and presented a discussion about the computational load. This approach is flexible and can be adapted to simulate more complex systems and topologies.
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