Sökning: WFRF:(Melvin Jennifer C.)
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Serum lipid profile...
Serum lipid profiles and cancer risk in the context of obesity : four meta-analyses.
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Melvin, Jennifer C (författare)
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- Holmberg, Lars (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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Rohrmann, Sabine (författare)
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Loda, Massimo (författare)
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Van Hemelrijck, Mieke (författare)
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(creator_code:org_t)
- Hindawi Limited, 2013
- 2013
- Engelska.
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Ingår i: Journal of Cancer Epidemiology. - : Hindawi Limited. - 1687-8558 .- 1687-8566. ; 2013, s. 823849-
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- The objective here was to summarize the evidence for, and quantify the link between, serum markers of lipid metabolism and risk of obesity-related cancers. PubMed and Embase were searched using predefined inclusion criteria to conduct meta-analyses on the association between serum levels of TG, TC, HDL, ApoA-I, and risk of 11 obesity-related cancers. Pooled relative risks (RRs) and 95% confidence intervals were estimated using random-effects analyses. 28 studies were included. Associations between abnormal lipid components and risk of obesity-related cancers when using clinical cutpoints (TC ≥ 6.50; TG ≥ 1.71; HDL ≤ 1.03; ApoA-I ≤ 1.05 mmol/L) were apparent in all models. RRs were 1.18 (95% CI: 1.08-1.29) for TC, 1.20 (1.07-1.35) for TG, 1.15 (1.01-1.32) for HDL, and 1.42 (1.17-1.74) for ApoA-I. High levels of TC and TG, as well as low levels of HDL and ApoA-I, were consistently associated with increased risk of obesity-related cancers. The modest RRs suggest serum lipids to be associated with the risk of cancer, but indicate it is likely that other markers of the metabolism and/or lifestyle factors may also be involved. Future intervention studies involving lifestyle modification would provide insight into the potential biological role of lipid metabolism in tumorigenesis.
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