| 1. |
- Reimerdes, H., et al.
(författare)
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Overview of the TCV tokamak experimental programme
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 62:4
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Tidskriftsartikel (refereegranskat)abstract
- The tokamak a configuration variable (TCV) continues to leverage its unique shaping capabilities, flexible heating systems and modern control system to address critical issues in preparation for ITER and a fusion power plant. For the 2019-20 campaign its configurational flexibility has been enhanced with the installation of removable divertor gas baffles, its diagnostic capabilities with an extensive set of upgrades and its heating systems with new dual frequency gyrotrons. The gas baffles reduce coupling between the divertor and the main chamber and allow for detailed investigations on the role of fuelling in general and, together with upgraded boundary diagnostics, test divertor and edge models in particular. The increased heating capabilities broaden the operational regime to include T (e)/T (i) similar to 1 and have stimulated refocussing studies from L-mode to H-mode across a range of research topics. ITER baseline parameters were reached in type-I ELMy H-modes and alternative regimes with 'small' (or no) ELMs explored. Most prominently, negative triangularity was investigated in detail and confirmed as an attractive scenario with H-mode level core confinement but an L-mode edge. Emphasis was also placed on control, where an increased number of observers, actuators and control solutions became available and are now integrated into a generic control framework as will be needed in future devices. The quantity and quality of results of the 2019-20 TCV campaign are a testament to its successful integration within the European research effort alongside a vibrant domestic programme and international collaborations.
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| 2. |
- Stroth, U., et al.
(författare)
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Progress from ASDEX Upgrade experiments in preparing the physics basis of ITER operation and DEMO scenario development
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 62:4
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Tidskriftsartikel (refereegranskat)abstract
- An overview of recent results obtained at the tokamak ASDEX Upgrade (AUG) is given. A work flow for predictive profile modelling of AUG discharges was established which is able to reproduce experimental H-mode plasma profiles based on engineering parameters only. In the plasma center, theoretical predictions on plasma current redistribution by a dynamo effect were confirmed experimentally. For core transport, the stabilizing effect of fast ion distributions on turbulent transport is shown to be important to explain the core isotope effect and improves the description of hollow low-Z impurity profiles. The L-H power threshold of hydrogen plasmas is not affected by small helium admixtures and it increases continuously from the deuterium to the hydrogen level when the hydrogen concentration is raised from 0 to 100%. One focus of recent campaigns was the search for a fusion relevant integrated plasma scenario without large edge localised modes (ELMs). Results from six different ELM-free confinement regimes are compared with respect to reactor relevance: ELM suppression by magnetic perturbation coils could be attributed to toroidally asymmetric turbulent fluctuations in the vicinity of the separatrix. Stable improved confinement mode plasma phases with a detached inner divertor were obtained using a feedback control of the plasma β. The enhanced D α H-mode regime was extended to higher heating power by feedback controlled radiative cooling with argon. The quasi-coherent exhaust regime was developed into an integrated scenario at high heating power and energy confinement, with a detached divertor and without large ELMs. Small ELMs close to the separatrix lead to peeling-ballooning stability and quasi continuous power exhaust. Helium beam density fluctuation measurements confirm that transport close to the separatrix is important to achieve the different ELM-free regimes. Based on separatrix plasma parameters and interchange-drift-Alfvén turbulence, an analytic model was derived that reproduces the experimentally found important operational boundaries of the density limit and between L- and H-mode confinement. Feedback control for the X-point radiator (XPR) position was established as an important element for divertor detachment control. Stable and detached ELM-free phases with H-mode confinement quality were obtained when the XPR was moved 10 cm above the X-point. Investigations of the plasma in the future flexible snow-flake divertor of AUG by means of first SOLPS-ITER simulations with drifts activated predict beneficial detachment properties and the activation of an additional strike point by the drifts.
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| 3. |
- De Leoz, M. L. A., et al.
(författare)
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NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods
- 2020
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476. ; 19:1, s. 11-30
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Tidskriftsartikel (refereegranskat)abstract
- A broad-based interlaboratory study of glycosylation profiles of a reference and modified IgG antibody involving 103 reports from 76 laboratories. Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.
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| 4. |
- Cioni, Lara, et al.
(författare)
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Fluorine Mass Balance, including Total Fluorine, Extractable Organic Fluorine, Oxidizable Precursors, and Target Per- and Polyfluoroalkyl Substances, in Pooled Human Serum from the Tromsø Population in 1986, 2007, and 2015
- 2023
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Ingår i: Environmental Science and Technology. - 0013-936X .- 1520-5851. ; 57:40, s. 14849-14860
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Tidskriftsartikel (refereegranskat)abstract
- Of the thousands of per- and polyfluoroalkyl substances (PFAS) known to exist, only a small fraction (≤1%) are commonly monitored in humans. This discrepancy has led to concerns that human exposure may be underestimated. Here, we address this problem by applying a comprehensive fluorine mass balance (FMB) approach, including total fluorine (TF), extractable organic fluorine (EOF), total oxidizable precursors (TOP), and selected target PFAS, to human serum samples collected over a period of 28 years (1986, 2007, and 2015) in Tromsø, Norway. While concentrations of TF did not change between sampling years, EOF was significantly higher in 1986 compared to 2007 and 2015. The ∑12PFAS concentrations were highest in 2007 compared to 1986 and 2015, and unidentified EOF (UEOF) decreased from 1986 (46%) to 2007 (10%) and then increased in 2015 (37%). While TF and EOF were not influenced by sex, women had higher UEOF compared to men, opposite to target PFAS. This is the first FMB in human serum to include TOP, and it suggests that precursors with >4 perfluorinated carbon atoms make a minor contribution to EOF (0–4%). Additional tools are therefore needed to identify substances contributing to the UEOF in human serum.
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| 5. |
- Hourihane, A., et al.
(författare)
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The Gaia-ESO Survey : Homogenisation of stellar parameters and elemental abundances
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 676
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Tidskriftsartikel (refereegranskat)abstract
- The Gaia-ESO Survey is a public spectroscopic survey that targeted greater than or similar to 10(5) stars covering all major components of the Milky Way from the end of 2011 to 2018, delivering its final public release in May 2022. Unlike other spectroscopic surveys, Gaia-ESO is the only survey that observed stars across all spectral types with dedicated, specialised analyses: from O (T-eff similar to 30 000-52 000 K) all the way to K-M (greater than or similar to 3500 K). The physics throughout these stellar regimes varies significantly, which has previously prohibited any detailed comparisons between stars of significantly different types. In the final data release (internal data release 6) of the Gaia-ESO Survey, we provide the final database containing a large number of products, such as radial velocities, stellar parameters and elemental abundances, rotational velocity, and also, for example, activity and accretion indicators in young stars and membership probability in star clusters for more than 114 000 stars. The spectral analysis is coordinated by a number of working groups (WGs) within the survey, each specialised in one or more of the various stellar samples. Common targets are analysed across WGs to allow for comparisons (and calibrations) amongst instrumental setups and spectral types. Here we describe the procedures employed to ensure all survey results are placed on a common scale in order to arrive at a single set of recommended results for use by all survey collaborators. We also present some general quality and consistency checks performed on the entirety of the survey results.
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| 6. |
- Jiang, Qiang, et al.
(författare)
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An appraisal of the ages of Phanerozoic large igneous provinces
- 2023
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Ingår i: Earth-Science Reviews. - : Elsevier. - 0012-8252 .- 1872-6828. ; 237
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Tidskriftsartikel (refereegranskat)abstract
- Large igneous provinces (LIPs) are the products of exceptional magmatic events that played important roles in tectonic plate reorganizations, environmental crises, energy resource formation and ore genesis. Studying the ages of LIPs has been crucial for constraining the duration of these magmatic events and deciphering their temporal relationship with associated geological events. There have been a significant number of radio-isotopic dating analyses (e.g., Ar-40/Ar-39, U-Pb) conducted for LIPs, especially in the past decade. These dating results have often been directly accepted and propagated into the literature for geological interpretations, regardless of their reliability and precision. This review compiles all published Ar-40/Ar-39 and U-Pb age determinations for the eighteen Phanerozoic large igneous provinces and critically evaluates each for their statistical robustness and precision. The compiled and filtered age data are easily accessible in an online database (https://shorturl. at/kIQT5) that will be regularly maintained by the authors. Using a filtered dataset of reliable and precise ages, which accounts for similar to 30% of all the originally published ages, we discuss the duration of large igneous provinces and compare their relative timing with mass extinctions and global environmental crises. We find that the filtered datasets indeed provide robust evidence for a short duration of a few million years for some LIPs (i.e., Emeishan LIP, Siberian Traps, Central Atlantic magmatic province, Karoo LIP, Ferrar LIP, Parana-Etendeka LIP, Deccan Traps, and Columbia River basalt group). However, evidence for the claimed short-lived, or long-lived and pulsed magmatism for some LIPs is insufficient (e.g., Yakutsk-Vilyui LIP, Kerguelen LIP, Caribbean LIP, High Arctic LIP, North Atlantic igneous province) and more robust geochronology data are needed to constrain their duration and tempo. The filtered data also strengthen the synchronicity between the peak magmatic phase of most LIPs and their associated environmental crises. Clear correlations are identified between the severity of environmental perturbations and LIPs' magma flux rates and likely their accompanied volatile degassing rates, indicating that LIP-induced rapid and intense volatile degassing may have been an important mechanism for a LIP to trigger the deterioration of the environment and even mass extinction.
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| 7. |
- Jiang, Qiang, et al.
(författare)
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Ar-40/Ar-39 dating of basaltic rocks and the pitfalls of plagioclase alteration
- 2021
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Ingår i: Geochimica et Cosmochimica Acta. - : Elsevier. - 0016-7037 .- 1872-9533. ; 314, s. 334-357
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Tidskriftsartikel (refereegranskat)abstract
- Ar-40/Ar-39 geochronology is one of the most important techniques for constraining the timing of basaltic events due to the paucity of suitable minerals in basalts for other geochronological techniques such as U-Pb (e.g., zircon, baddeleyite). Among a variety of materials from basaltic rocks that have been used for Ar-40/Ar-39 dating, plagioclase is the most important due to its common presence in basalts as a primary crystallizing phase, and its transparency so that fresh grains can be selected during sample preparation. However, plagioclase Ar-40/Ar-39 geochronology has often been compromised by alteration (e.g., sericitization by hydrothermal events), which, in practice, is difficult to identify using a petrographic microscope when the amount of alteration is low (e.g., <1%). We used laboratory step-heating experiments and theoretical simulations to characterize the Ar-40/Ar-39 age and Ca/K spectra of altered plagioclase so that Ar-40/Ar-39 dating results on altered samples can be identified and better interpreted. The step-heating experiments and theoretical simulations yielded consistent results, and show that with the presence of even a tiny amount of sericite (similar to 0.01% for K-poor samples and similar to 0.1% for K-rich samples), the plagioclase samples yielded alteration plateau ages that are 3%-4% younger than the crystallization age. The difference between the alteration age of sericitized plagioclase and its crystallization age is primarily controlled by the time lapse between the crystallization and sericitization events, but also by the Ca/K ratios of the plagioclase. For plagioclase samples that experienced the same alteration event, the higher the Ca/K ratio is, the more sensitive the Ar-40/Ar-39 age is to alteration. We propose that the alteration signatures of plagioclase can be effectively identified through inspecting the Ar-40/Ar-39 age spectra, the Ca/K spectra, and the degassing curves. We also investigated the effect of sericitization of plagioclase microliths in basaltic groundmass and modelled the Ar-40/Ar-39 age and Ca/K spectra of altered groundmass samples. We validate our approach by revisiting published Ar-40/Ar-39 dating results for large igneous provinces, and showed that these dates should have been interpreted as alteration ages (minimum eruption ages) rather than crystallization ages. Finally, we demonstrate that with high degrees of alteration (similar to 50% for K-poor and >70% for K-rich plagioclase samples), the age of hydrothermal alteration can be successfully dated. (C) 2021 Elsevier Ltd. All rights reserved.
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| 8. |
- Jiang, Qiang, et al.
(författare)
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Longest continuously erupting large igneous province driven by plume-ridge interaction
- 2021
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Ingår i: Geology. - 0091-7613 .- 1943-2682. ; 49:2, s. 206-210
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Tidskriftsartikel (refereegranskat)abstract
- Large igneous provinces (LIPs) typically form in one short pulse of ∼1–5 Ma or several punctuated ∼1–5 Ma pulses. Here, our 25 new 40Ar/39Ar plateau ages for the main construct of the Kerguelen LIP—the Cretaceous Southern and Central Kerguelen Plateau, Elan Bank, and Broken Ridge—show continuous volcanic activity from ca. 122 to 90 Ma, a long lifespan of >32 Ma. This suggests that the Kerguelen LIP records the longest, continuous high-magma-flux emplacement interval of any LIP. Distinct from both short-lived and multiple-pulsed LIPs, we propose that Kerguelen is a different type of LIP that formed through long-term interactions between a mantle plume and mid-ocean ridge, which is enabled by multiple ridge jumps, slow spreading, and migration of the ridge. Such processes allow the transport of magma products away from the eruption center and result in long-lived, continuous magmatic activity.
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| 9. |
- Jiang, Qiang, et al.
(författare)
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Origin of geochemically heterogeneous mid-ocean ridge basalts from the Macquarie Ridge Complex, SW Pacific
- 2021
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Ingår i: Lithos. - : Elsevier. - 0024-4937 .- 1872-6143. ; 380-381
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Tidskriftsartikel (refereegranskat)abstract
- The Macquarie Ridge Complex (MRC), located at the Australian–Pacific plate boundary south of New Zealand, is a rugged bathymetric ridge comprising a series of submarine seamounts and Macquarie Island, the only subaerial portion of the complex. Mid-ocean ridge basalts (MORBs) from Macquarie Island show various enrichments in incompatible elements with compositions ranging from typical normal MORB to enriched MORB. However, these basalts have isotopic compositions trending towards a high μ-like (μ = 238U/204Pb; HIMU) mantle component, which is unusual for MORB-type rocks. The origin of this mantle signature is not understood, and it is unclear whether this isotopic signature is characteristic of the entire MRC or unique to Macquarie Island. Here we report new major and trace element abundances, and Sr, Nd, and Pb isotopes for samples from the MRC seamounts and from new sampling sites on Macquarie Island. The geochemical and isotopic data show that the entire MRC comprises normal to enriched MORB. Mixing modelling indicates that the heterogeneous isotopic signatures of the MRC basalts are not derived from contamination of the nearby Balleny mantle plume but have affinities with that of the Cenozoic Zealandia intraplate HIMU-like basalts. We propose that the heterogeneous geochemical signatures of the MRC basalts are derived from amphibole-bearing garnet pyroxenite veins, which is supported by the rare earth element partial melting modelling and strong correlations between Nd and Pb isotopic ratios vs La/Sm. We posit that the pyroxenite veins were generated in the oceanic lithospheric mantle, which was metasomatised by hydrous and carbonatitic fluids/melts derived either from delaminated, metasomatised Zealandia subcontinental lithosphere mantle, or from subducted material in the asthenosphere. The subducted material could be derived from ancient and/or recent subduction along the former east Gondwana margin.
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| 10. |
- Jiang, Qiang, et al.
(författare)
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Timing of Seafloor Spreading Cessation at the Macquarie Ridge Complex (SW Pacific) and Implications for Upper Mantle Heterogeneity
- 2021
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Ingår i: Geochemistry Geophysics Geosystems. - : American Geophysical Union (AGU). - 1525-2027. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- The Macquarie Ridge Complex (MRC) on the Australia‐Pacific plate boundary south of New Zealand is an extinct mid‐ocean ridge that has experienced a complex tectonic history and produced highly heterogeneous mid‐ocean ridge basalts (MORBs). When and how seafloor spreading ceased along the proto‐Macquarie mid‐ocean ridge remain elusive, and it is unclear how the mantle source of MORBs is affected by the gradual cessation of seafloor spreading at mid‐ocean ridges. To constrain the tectonic evolution of the MRC, the mantle source variations for MORBs at dying mid‐ocean ridges, and the mechanisms of mantle enrichment and asthenospheric heterogeneities, we report 11 pyroxene, plagioclase, basaltic glass, groundmass, and sericite 40Ar/39Ar and one zircon U‐Pb ages for the MRC MORBs. Our data reveal that basalts from the MRC seamounts were erupted between 25.9 and 1.6 Ma and Macquarie Island at ∼10 Ma. Combined age and plate reconstruction results reveal that the cessation of seafloor spreading at the MRC generally propagated from south to north along the ridge. Basalts produced by the then dying Macquarie mid‐ocean ridge at different times on different seamounts/island show a large variation in isotopic compositions and there is no clear correlation between ages and isotopic ratios. The heterogeneity of mantle source for MORBs from the proto‐Macquarie mid‐ocean ridge suggests that the upper asthenospheric mantle is heterogeneous, and such heterogeneity becomes most obvious at dying mid‐ocean ridges where the degrees of partial melting are low and a large range of melt compositions are produced.
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