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Sökning: WFRF:(Meza M) > (2010-2014)

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1.
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2.
  • Kresse, Stine H., et al. (författare)
  • Integrative Analysis Reveals Relationships of Genetic and Epigenetic Alterations in Osteosarcoma
  • 2012
  • Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Osteosarcomas are the most common non-haematological primary malignant tumours of bone, and all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based on microarray technologies. Principal Findings: The cell lines showed complex patterns of DNA copy number changes, where genomic copy number gains were significantly associated with gene-rich regions and losses with gene-poor regions. By integrating the datasets, 350 genes were identified as having two types of aberrations (gain/over-expression, hypo-methylation/over-expression, loss/under-expression or hyper-methylation/under-expression) using a recurrence threshold of 6/19 (>30%) cell lines. The genes showed in general alterations in either DNA copy number or DNA methylation, both within individual samples and across the sample panel. These 350 genes are involved in embryonic skeletal system development and morphogenesis, as well as remodelling of extracellular matrix. The aberrations of three selected genes, CXCL5, DLX5 and RUNX2, were validated in five cell lines and five tumour samples using PCR techniques. Several genes were hyper-methylated and under-expressed compared to normal osteoblasts, and expression could be reactivated by demethylation using 5-Aza-2′-deoxycytidine treatment for four genes tested; AKAP12, CXCL5, EFEMP1 and IL11RA. Globally, there was as expected a significant positive association between gain and over-expression, loss and under-expression as well as hyper-methylation and under-expression, but gain was also associated with hyper-methylation and under-expression, suggesting that hyper-methylation may oppose the effects of increased copy number for detrimental genes. Conclusions: Integrative analysis of genome-wide genetic and epigenetic alterations identified dependencies and relationships between DNA copy number, DNA methylation and mRNA expression in osteosarcomas, contributing to better understanding of osteosarcoma biology. © 2012 Kresse et al.
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3.
  • Meza-Sánchez, Iliana M., et al. (författare)
  • Nonlinear output feedback H∞-tracking control of a 3-DOF underactuated helicopter
  • 2011
  • Ingår i: 18th IFAC World Congress. - : Elsevier. - 9783902661937 ; , s. 11145-11150
  • Konferensbidrag (refereegranskat)abstract
    • Nonlinear H∞-control synthesis is developed to solve the tracking control problem to induce periodic behavior in a 3-DOF underactuated helicopter prototype. Due to the nature of the approach, the proposed controller yields the desired robustness properties against unknown bounded external disturbances. Stabilizability and detectability properties of the control system are ensured by the existence of proper solutions of the corresponding differential Riccati equations. Virtual constraints approach for motion planning is considered prior the controller design in order to achieve the control goal. Performance issues of the proposed controller are illustrated via numerical simulations. 
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4.
  • Meza-Sanchez, Iliana M, et al. (författare)
  • Periodic motion planning and nonlinear H-infinity tracking control of a 3-DOF underactuated helicopter
  • 2011
  • Ingår i: International Journal of Systems Science. - : Informa UK Limited. - 0020-7721 .- 1464-5319. ; 42:5, s. 829-838
  • Tidskriftsartikel (refereegranskat)abstract
    • Nonlinear H-infinity synthesis is developed to solve the tracking control problem into a 3-DOF helicopter prototype. Planning of periodic motions under a virtual constraints approach is considered prior the controller design in order to achieve our goal. A local H-infinity controller is derived by means of a certain perturbation of the differential Riccati equations that appear while solving the corresponding H-infinity control problem for the linearised system. Stabilisability and detectability properties of the control system are thus ensured by the existence of the proper solutions of the unperturbed differential Riccati equations, and hence the proposed synthesis procedure obviates an extra verification work of these properties. Due to the nature of the approach, the resulting controller additionally yields the desired robustness properties against unknown but bounded external disturbances. Convergence and robustness of the proposed design are supported by simulation results.
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  • Resultat 1-4 av 4

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