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- Bunting, M J, et al.
(författare)
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Vegetation structure and pollen source area
- 2004
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Ingår i: The Holocene. - : SAGE Publications. - 0959-6836 .- 1477-0911. ; 14:5, s. 651-660
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we use a simulation approach to explore the effect of variation in taxon parameters and landscape patterning on relevant source area of pollen. We use the Prentice-Sugita model, assume constant atmospheric conditions and basin morphology, and take a reductionist approach to explore the behaviour of pollen dispersal and deposition in a simple landscape scenario. Individual factors within the scenario (pollen fall speed, relative pollen productivity, size of basic unit in the landscape mosaic, patch size, rarity of individual taxa and overall number of taxa present in the landscape) are varied while all other parameters are kept constant, thus permitting exploration of the role of different components of the system. These simulations suggest that, for basins of given size under fixed atmospheric conditions, the relevant source area of pollen is primarily an expression of the patterning of the different vegetation elements within the landscape. This has important implications for the interpretation of palaeoecological records and reconstruction of past environments. Reconstruction, especially quantitative reconstruction, requires some estimate of past relevant source area of pollen. If, as our results suggest, vegetation patterning is an important determinant of this, then it must also be taken into account when attempting to reconstruct past vegetation communities.
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- Williams, P., et al.
(författare)
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Quorum sensing and the population-dependent control of virulence
- 2000
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Ingår i: Philosophical Transactions of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8436 .- 1471-2970. ; 355:1397, s. 667-680
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Forskningsöversikt (refereegranskat)abstract
- One crucial feature of almost all bacterial infections is the need for the invading pathogen to reach a critical cell population density sufficient to overcome host defences and establish the infection. Controlling the expression of virulence determinants in concert with cell population density may therefore confer a significant survival advantage on the pathogen such that the host is overwhelmed before a defence response can be fully initiated. Many different bacterial pathogens are now known to regulate diverse physiological processes including virulence in a cell-density-dependent manner through cell-cell communication. This phenomenon, which relies on the interaction of a diffusible signal molecule (e.g. an N-acylhomoserine lactone) with a sensor or transcriptional activator to couple gene expression with cell population density, has become known as 'quorum sensing'. Although the size of the 'quorum' is likely to be highly variable and influenced by the diffusibility of the signal molecule within infected tissues, nevertheless quorum-sensing signal molecules can be detected in vivo in both experimental animal model and human infections. Furthermore, certain quorum-sensing molecules have been shown to possess pharmacological and immunomodulatory activity such that they may function as virulence determinants per se. As a consequence, quorum sensing constitutes a novel therapeutic target for the design of small molecular antagonists capable of attenuating virulence through the blockade of bacterial cell-cell communication.
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