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- Luo, Y., et al.
(författare)
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Some recent developments of high-order response theory
- 1998
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Ingår i: International Journal of Quantum Chemistry. - 0020-7608 .- 1097-461X. ; 70:1, s. 219-239
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Tidskriftsartikel (refereegranskat)abstract
- We review some recent developments of high-order response theory and illustrate the utility of this theory for a selection of nonlinear properties. © 1998 John Willey & Sons, Inc.
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- Mikkelsen, Nils E, et al.
(författare)
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Inhibition of RNase P cleavage by aminoglycosides
- 1999
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - 0027-8424 .- 1091-6490. ; 96:11, s. 6155-6160
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Tidskriftsartikel (refereegranskat)abstract
- A number of aminoglycosides have been reported to interact and interfere with the function of various RNA molecules. Among these are 16S rRNA, the group I intron, and the hammerhead ribozymes. In this report we show that cleavage by RNase P RNA in the absence as well as in the presence of the RNase P protein is inhibited by several aminoglycosides. Among the ones we tested, neomycin B was found to be the strongest inhibitor with a Ki value in the micromolar range (35 microM). Studies of lead(II)-induced cleavage of RNase P RNA suggested that binding of neomycin B interfered with the binding of divalent metal ions to the RNA. Taken together, our findings suggest that aminoglycosides compete with Mg2+ ions for functionally important divalent metal ion binding sites. Thus, RNase P, which is an essential enzyme, is indeed a potential drug target that can be used to develop new drugs by using various aminoglycosides as lead compounds.
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