| 1. |
- Aad, G., et al.
(author)
-
- 2014
-
In: Journal of High Energy Physics. - : Springer. - 1029-8479 .- 1126-6708. ; :6
-
Journal article (peer-reviewed)
|
|
| 2. |
- Patel, Yashwant Singh, et al.
(author)
-
Formal models for the energy-aware cloud-edge computing continuum : analysis and challenges
- 2023
-
In: 2023 IEEE international conference on service-oriented system engineering (SOSE). - : IEEE. - 9798350322392 - 9798350322408 ; , s. 48-59
-
Conference paper (peer-reviewed)abstract
- Cloud infrastructures are rapidly evolving from centralised systems to geographically distributed federations of edge devices, fog nodes, and clouds. These federations (often referred to as the Cloud-Edge Continuum) are the foundation upon which most modern digital systems depend, and consume enormous amounts of energy. This consumption is becoming a critical issue as society's energy challenges grow, and is a great concern for power grids which must balance the needs of clouds against other users. The Continuum is highly dynamic, mobile, and complex; new methods to improve energy efficiency must be based on formal scientific models that identify and take into account a huge range of heterogeneous components, interactions, stochastic properties, and (potentially contradictory) service-level agreements and stakeholder objectives. Currently, few formal models of federated Cloud-Edge systems exist - and none adequately represent and integrate energy considerations (e.g. multiple providers, renewable energy sources, pricing, and the need to balance consumption over large-areas with other non-Cloud consumers, etc.). This paper conducts a systematic analysis of current approaches to modelling Cloud, Cloud-Edge, and federated Continuum systems with an emphasis on the integration of energy considerations. We identify key omissions in the literature, and propose an initial high-level architecture and approach to begin addressing these - with the ultimate goal to develop a set of integrated models that include data centres, edge devices, fog nodes, energy providers, software workloads, end users, and stakeholder requirements and objectives. We conclude by highlighting the key research challenges that must be addressed to enable meaningful energy-aware Cloud-Edge Continuum modelling and simulation.
|
|
| 3. |
- Minzi, OMS, et al.
(author)
-
Existence of antimalarial formulations with low bioavailability in Tanzania
- 2006
-
In: Tropical doctor. - : SAGE Publications. - 0049-4755 .- 1758-1133. ; 36:2, s. 93-97
-
Journal article (peer-reviewed)abstract
- The main objective of this work was to assess the relative bioavailability of two tablet formulations containing sulfadoxine/pyrimethamine (SP) and marketed in Tanzania. Twelve healthy volunteers were randomized to receive a single oral dose of three SP tablets each containing 500 mg sulfadoxine (SDX) and 25 mg pyrimethamine (PYR) in a form of either A (a locally manufactured SP tablet formulation, manufactured by a local pharmaceutical industry in Tanzania) or B (Fansidar®, Hoffmann La Roche, Basel, Switzerland, an innovator's SP) after an overnight fasting. Serial blood samples (100 μL) were collected from a finger prick in duplicate up to 10 days and dried on Whatman® filter paper. The samples were assayed for SDX and PYR using high-performance liquid chromatographic methods. Pharmacokinetic parameters of SDX and PYR were estimated by single compartment method. The pharmacokinetics of formulation A - maximum plasma concentration, the areas under the plasma concentration - time curve and the relative bioavailability (A versus B) were significantly lower than those of formulation B ( P<0.1). These observed differences indicate bioinequivalence between the two products.
|
|
| 4. |
- Cederkrantz, Elin, et al.
(author)
-
Evaluation of Effects on the Peritoneum After Intraperitoneal α-Radioimmunotherapy with (211)At.
- 2012
-
In: Cancer biotherapy & radiopharmaceuticals. - : Mary Ann Liebert Inc. - 1557-8852 .- 1084-9785. ; 27:6, s. 353-364
-
Journal article (peer-reviewed)abstract
- Abstract The introduction of the short-lived α-emitter (211)At to intraperitoneal radioimmunotherapy has raised the issue of the tolerance dose of the peritoneum. The short range of the α-particles (70μm) and the short half-life (7.21h) of the nuclide yield a dose distribution in which the peritoneum is highly irradiated compared with other normal tissues. To address this issue, mice were injected with (211)At-trastuzumab to irradiate the peritoneum to absorbed doses ranging between 0 and 50 Gy and followed for up to 34 weeks. The peritoneum-to-plasma clearance of a small tracer, (51)Cr-ethylenediamine tetraacetic acid, was measured for evaluation of the small solute transport capacity of the peritoneal membrane. The macroscopic status of the peritoneum and the mesenteric windows was documented when the mice were sacrificed. Biopsies of the peritoneum were taken for morphology and immunohistochemical staining against plasminogen activator inhibitor-1 and calprotectin. Peritoneum-to-plasma clearance measurements indicated a dose-dependent decrease in peritoneal transport capacity in irradiated mice. However, macroscopic and microscopic evaluations of the peritoneal membrane showed no difference between irradiated mice versus controls. The results imply that the peritoneal membrane tolerates absorbed doses as high as 30-50 Gy from α-particle irradiation with limited response.
|
|
| 5. |
|
|
| 6. |
- Nylander, Stina, et al.
(author)
-
Ubiquitous service access through adapted user interfaces on multiple devices
- 2005. - 1
-
In: Personal and Ubiquitous Computing. - : Springer Science and Business Media LLC. - 1617-4909 .- 1617-4917. ; 9, s. 123-133
-
Journal article (peer-reviewed)abstract
- The Ubiquitous Interactor (UBI) addresses the problems of design and development that arise from services that need to be accessed from many different devices. In the UBI, a service can present itself with different user interfaces on different devices. This is done by a separation of the user-service interaction and presentation. The interaction is kept the same for all devices, and different presentation information is provided for different devices. This way, tailored user interfaces for many different devices can be created without multiplying the development and maintenance work. In this paper, we describe the design of the UBI, the system implementation, and two services implemented for the system: a calendar service and a stockbroker service.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
