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Träfflista för sökning "WFRF:(Mitchell Peter J) srt2:(2000-2004)"

Sökning: WFRF:(Mitchell Peter J) > (2000-2004)

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1.
  • Suuronen, Erik J., et al. (författare)
  • Innervated human corneal equivalents as in vitro models for nerve-target cell interactions
  • 2003
  • Ingår i: The FASEB Journal. - : Federation of American Society of Experimental Biology (FASEB). - 0892-6638 .- 1530-6860. ; 17, s. 170-
  • Tidskriftsartikel (refereegranskat)abstract
    • A sensory nerve supply is crucial for optimal tissue function. However, the mechanisms for successful innervation and the signaling pathways between nerves and their target tissue are not fully understood. Engineered tissue substitutes can provide controllable environments in which to study tissue innervation. We have therefore engineered human corneal substitutes that promote nerve in-growth in a pattern similar to in vivo re-innervation. We demonstrate that these nerves (a) are morphologically equivalent to natural corneal nerves; (b) make appropriate contact with target cells; (c) can generate action potentials; (d) respond to chemical and physical stimuli; and (e) play an important role in the overall functioning of the bioengineered tissue. This model can be used for studying the more general topics of nerve ingrowth or regeneration and the interaction between nerves and their target cells and, more specifically, the role of nerves in corneal function. This model could also be used as an in vitro alternative to animals for safety and efficacy testing of chemicals and drugs.
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2.
  • Kadioglu, Aras, et al. (författare)
  • Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo
  • 2001
  • Ingår i: FEMS Microbiology Letters. - 1574-6968. ; 194:1, s. 105-110
  • Tidskriftsartikel (refereegranskat)abstract
    • The pneumococcus is the principle cause of bacterial pneumonia and also a major cause of bacterial meningitis. The mechanisms and sites of pneumococcal adherence and invasion of the respiratory tract in vivo are not clear however. We have made pneumococci expressing green fluorescent protein (GFP) and used it to trace pneumococcal adherence and invasion in vivo. By using GFP pneumococci we have shown bacterial adherence and invasion of broncho-epithelial cells in vivo by 4 h post-infection, with increases in pneumococcal invasiveness by 24 h. Using confocal image analysis we have shown varying levels of pneumococcal penetration and internalisation into host cells, as well as translocation through epithelial layers. To our knowledge this is the first report of pneumococcal invasion and cellular translocation in vivo.
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