| 1. |
|
|
| 2. |
- Forcato, M., et al.
(författare)
-
Chiral, enantiopure aluminum(III) and titanium(IV) azatranes
- 2006
-
Ingår i: European Journal of Inorganic Chemistry. - : Wiley. - 1434-1948 .- 1099-1948 .- 1099-0682. ; :5, s. 1032-1040
-
Tidskriftsartikel (refereegranskat)abstract
- Al-III and Ti-IV complexes of C-3-symmetric tetradentate trisamidoamme ligands with trigonal bipyramidal coordination geometry, containing chlorine or dialkylamido groups, or with a free coordination site in the apical position, have been synthesised by salt metathesis and amine elimination. Products with threefold symmetry were generally obtained for tetravalent titanium, whereas for the aluminium complexes either asymmetric structures with two of the three podand arms taking part in coordination to the metal or symmetric arrangements possessing the full threefold symmetry were formed depending on the steric properties of the ligands.
|
|
| 3. |
- Dreilich, M., et al.
(författare)
-
High-risk human papilloma virus (HPV) and survival in patients with esophageal carcinoma : a pilot study
- 2006
-
Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 6, s. 94-
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papilloma virus (HPV) in patients with esophageal carcinoma has previously been studied with an average detection rate of 15%, but the role of HPV in relation to survival is less clear. In cervical cancer, lung cancer and tonsil cancer HPV viral load is a predictive factor for survival and outcome of treatment. The primary aim was to study the spectrum of high-risk HPV types in esophageal tumors. Secondary, as a pilot study we investigated the association between HPV status and the survival rates. METHODS: We compared both the presence and the viral load of high-risk HPV types 16, 18, 31, 33, 39, 45, 52, 58, and 67 in relation to clinical data from patients with esophageal carcinoma. Survival data and tumor samples were retrieved from 100 patients receiving treatment at the Department of Oncology, Uppsala Hospital, Uppsala, Sweden. The tumor samples were investigated for HPV viral load using real-time PCR. RESULTS: HPV 16 was detected in 16% of the patients; no other HPV type was detected. HPV 16 infection had no significant effect on survival (p = 0.72). Also, HPV 16 did not improve survival after treatment (radiotherapy or chemotherapy). CONCLUSION: Only HPV 16 was detected among the patients. HPV 16 in esophageal carcinoma patients did not influence survival or improve therapy response. However, given the size of the study there is a need to examine a larger cohort in order to understand in more detail the effect of high risk HPV types in esophageal carcinoma.
|
|
| 4. |
|
|
| 5. |
- Grutters, Michiel M. P., et al.
(författare)
-
Highly Selective Cobalt-Catalyzed Hydrovinylation of Styrene
- 2009
-
Ingår i: Advanced Synthesis and Catalysis. - : Wiley. - 1615-4150 .- 1615-4169. ; 351:13, s. 2199-2208
-
Tidskriftsartikel (refereegranskat)abstract
- Phosphine complexes of cobalt halide salts activated by diethylaluminum chloride are shown to yield highly active catalysts in the hydrovinylation of styrene, with unprecedented high selectivity to the desired product 3-phenyl-1-butene (3P1B). Double-bond isomerization, a common problem in codimerization reactions, only occurs after full conversion with these catalyst systems, even at elevated temperature. The most active catalysts are based on cobalt halide species combined with either C-1- or C-2-bridged diphosphines, heterodonor P,N or P,O ligands, flexible bidentate phosphine ligands or monodentate phosphine ligands. Kinetic investigations show an order > 1 in catalyst, which indicates either the involvement of dinuclear species in the catalytic cycle or partial catalyst decomposition via a bimolecular pathway.
|
|
| 6. |
- Moberg, Viktor, et al.
(författare)
-
Synthesis, characterization and reactivity of tetranuclear ruthenium hydrido clusters containing chiral phosphine ligands
- 2006
-
Ingår i: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9234. ; :1, s. 279-288
-
Tidskriftsartikel (refereegranskat)abstract
- The chiral clusters [H4Ru4(CO)(12-n)(L)(n)] (n = 1, 2; L = NMDPP), 1,1-[H4Ru4(CO)(10)(L - L)] (L - L = DUPHOS, DIPAMP), 1,2-[H4Ru4(CO)(10)(DIOP)] and [{H4Ru4(CO)(10)(DIOP)}(2)] have been synthesized by derivatizing the parent carbonyl cluster [H4Ru4(CO)(12)] with the appropriate mono- or didentate chiral phosphine ligand. The phosphine-substituted clusters were found to be able to catalyze the ( asymmetric) hydrogenation of tiglic acid albeit with relatively low selectivity (enantiomeric excesses varying from 0 to 23%). It was found that the stability of the chiral ruthenium hydride clusters and the product distribution obtained in the catalytic reactions are dependent on the nature of the chiral phosphine. The crystal structures of [H4Ru4(CO)(12-n)(L)(n)] (n = 1, 2; L = NMDPP), 1,1-[H4Ru4(CO)(10)(L-L)] (L - L = DUPHOS, O-DUPHOS ( partially oxygenated ligand), DIPAMP), 1,2-[H4Ru4(CO)(10)(DIOP)] and [{H4Ru4(CO)(10)(DIOP)}(2)] are presented.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
