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Pregnancy outcomes in inflammatory bowel disease patients treated with vedolizumab, anti-TNF or conventional therapy : results of the European CONCEIVE study
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- Moens, Annick (författare)
- Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Ageing, Ku Leuven, Leuven, Belgium
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- van der Woude, C. Janneke (författare)
- Erasmus MC, Rotterdam, Netherlands
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- Julsgaard, Mette (författare)
- Aarhus University Hospital, Aarhus, Denmark
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- Humblet, Evelien (författare)
- Ziekenhuis Oost‐Limburg ‐ Campus Sint‐Jan, Genk, Belgium
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- Sheridan, Juliette (författare)
- St. Vincent's University Hospital, Dublin, Ireland
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- Baumgart, Daniel C. (författare)
- University of Alberta, Edmonton AB, Canada
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- De Saint-Joseph, Cyrielle Gilletta (författare)
- Hôpital Rangueil, Toulouse, France
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- Nancey, Stéphane (författare)
- CHU Lyon, Lyon, France
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- Rahier, Jean-Francois (författare)
- CHU UCL Namur, Université catholique de Louvain, Yvoir, Belgium
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- Bossuyt, Peter (författare)
- Imeldaziekenhuis, Bonheiden, Belgium
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- Cremer, Anneline (författare)
- Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium
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- Dewit, Sophie (författare)
- Mariaziekenhuis Noord-Limburg, Overpelt, Belgium
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- Eriksson, Carl, 1981- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län
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- Hoentjen, Frank (författare)
- Radboud University Medical Center, Nijmegen, The Netherland
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- Krause, Thomas (författare)
- Opernstrasse, Kassel, Germany
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- Louis, Edouard (författare)
- CHU Liege, Liege, Belgium
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- Macken, Elisabeth (författare)
- Universiteit zieken‐huis Antwerpen UZA, Belgium
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- Milenkovic, Zoran (författare)
- Military Medical Academy Belgrade, Belgrade, Serbia
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- Nijs, Jochen (författare)
- Sint‐Trudo Ziekenhuis, Sint‐Truiden, Belgium
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- Posen, Annelies (författare)
- AZ Vesalius, Tongeren, Belgium
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- Van Hootegem, Anneleen (författare)
- AZ Klina, Brasschaat, Belgium
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- Van Moerkercke, Wouter (författare)
- AZ Groeninge, Kortrijk, Belgium
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- Vermeire, Severine (författare)
- Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Ageing, Ku Leuven, Leuven, Belgium
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- Shitrit, Ariella Bar-Gil (författare)
- Shaare Zedek Medical Center, Hebrew University Jerusalem, Jerusalem, Israel
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- Ferrante, Marc (författare)
- Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Ageing, Ku Leuven, Leuven, Belgium
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(creator_code:org_t)
- 2019-11-06
- 2020
- Engelska.
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Blackwell Publishing. - 0269-2813 .- 1365-2036. ; 51:1, s. 129-138
- Relaterad länk:
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https://doi.org/10.1...
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https://orbi.uliege....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Women with inflammatory bowel diseases (IBD) often receive biologicals during pregnancy to maintain disease remission. Data on outcome of vedolizumab-exposed pregnancies (VDZE) are sparse.Aims: The aim was to assess pregnancy and child outcomes of VDZE pregnancies and to compare these results to anti-TNF exposed (TNFE) or both immunomodulatory and biologic unexposed (CON IBD) pregnancies.Methods: A retrospective multicentre case-control observational study was performed.Results: VDZE group included 79 pregnancies in 73 IBD women. The TNFE and CON IBD group included 186 pregnancies (162 live births) in 164 IBD women and 184 pregnancies (163 live births) in 155 IBD women, respectively. At conception, cases more often had active disease ([VDZE: 36% vs TNFE: 17%, P = .002] and [VDZE: 36% vs CON IBD: 24%, P = .063]). No significant difference in miscarriage rates were found between groups (VDZE and TNFE: 16% vs 13%, P = .567; VDZE and CON IBD: 16% vs 10%, P = .216). In live-born infants, median gestational age and birthweight were similar between groups. Median Apgar score at birth was numerically equal. Prematurity was similar in the VDZE group compared to the control groups, even when correcting for disease activity during pregnancy. The frequency of congenital anomalies was comparable between groups as were the percentages of breastfed babies. During the first year of life, no malignancies were reported and infants' infection risk did not significantly differ between groups.Conclusion: No new safety signal was detected in VDZE pregnancies although larger, prospective studies are required for confirmation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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Moens, Annick
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van der Woude, C ...
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Julsgaard, Mette
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Humblet, Evelien
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Sheridan, Juliet ...
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Baumgart, Daniel ...
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De Saint-Joseph, ...
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Nancey, Stéphane
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Rahier, Jean-Fra ...
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Bossuyt, Peter
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Cremer, Anneline
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Dewit, Sophie
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Eriksson, Carl, ...
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Hoentjen, Frank
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Krause, Thomas
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Louis, Edouard
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Macken, Elisabet ...
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Milenkovic, Zora ...
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Nijs, Jochen
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Posen, Annelies
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Van Hootegem, An ...
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Van Moerkercke, ...
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Vermeire, Severi ...
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Shitrit, Ariella ...
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Ferrante, Marc
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Örebro universitet