| 1. |
- Hassing, H. C., et al.
(författare)
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SULF2 Strongly Prediposes to Fasting and Postprandial Triglycerides in Patients with Obesity and Type 2 Diabetes Mellitus
- 2014
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Ingår i: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 22:5, s. 1309-1316
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Hepatic overexpression of sulfatase-2 (SULF2), a heparan sulfate remodeling enzyme, strongly contributes to high triglyceride (TG) levels in obese, type 2 diabetic (T2DM) db/db mice. Nevertheless, data in humans are lacking. Here, the association of human hepatic SULF2 expression and SULF2 gene variants with TG metabolism in patients with obesity and/or T2DM was investigated. Methods: Liver biopsies from 121 obese subjects were analyzed for relations between hepatic SULF2 mRNA levels and plasma TG. Associations between seven SULF2 tagSNPs and TG levels were assessed in 210 obese T2DM subjects with dyslipidemia. Replication of positive findings was performed in 1,316 independent obese T2DM patients. Postprandial TRL clearance was evaluated in 29 obese T2DM subjects stratified by SULF2 genotype. Results: Liver SULF2 expression was significantly associated with fasting plasma TG (r = 0.271; P = 0.003) in obese subjects. The SULF2 rs2281279(A>G) SNP was reproducibly associated with lower fasting plasma TG levels in obese T2DM subjects (P < 0.05). Carriership of the minor G allele was associated with lower levels of postprandial plasma TG (P < 0.05) and retinyl esters levels (P < 0.001). Conclusions: These findings implicate SULF2 as potential therapeutic target in the atherogenic dyslipidemia of obesity and T2DM.
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| 2. |
- Oberstedt, S., et al.
(författare)
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High-precision prompt-gamma-ray spectral data from the reaction Pu-241(n(th), f)
- 2014
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 90:2, s. Art. no. 024618-
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we present results from the first high-precision prompt-gamma-ray spectral measurements from the reaction Pu-241(n(th), f). Apart from one recent experiment, no data are reported in the literature for this fissioning system, which motivated a new dedicated experiment. We have measured prompt-fission gamma rays with three cerium-doped LaBr3 (two 5.08 cm x 5.08 cm and one 7.62 cm x 7.62 cm) and one CeBr3 (5.08 cm x 5.08 cm) scintillation detectors, which all exhibit excellent timing and good energy resolution. The average gamma-ray multiplicity was determined to be (nu) over bar (gamma) = (8.21 +/- 0.09) per fission, the average energy to be epsilon(gamma) = (0.78 +/- 0.01) MeV, and the total energy to be E-gamma,E-tot = (6.41 +/- 0.06) MeV as the weighted average from all detectors. Since the results from all detectors are in excellent agreement, and the total released gamma energy is modestly higher than the one in the present evaluated nuclear data files, we suspect that the underestimation of the prompt-gamma heating in nuclear reactors is due to fast-neutron-induced fission on U-238 or rather from fission induced by gamma rays from neutron capture in the construction material.
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