| 1. |
- Sodergren, Erica, et al.
(författare)
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The genome of the sea urchin Strongylocentrotus purpuratus.
- 2006
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 314:5801, s. 941-52
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Tidskriftsartikel (refereegranskat)abstract
- We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.
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| 2. |
- Soranzo, Nicole, et al.
(författare)
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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:11, s. 38-1182
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Tidskriftsartikel (refereegranskat)abstract
- The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
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| 3. |
- Abd El Ghany, M. A., et al.
(författare)
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High throughput architecture for CLICHÉ network on chip
- 2009
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Ingår i: Proceedings - IEEE International SOC Conference, SOCC 2009. - 9781424452200 ; , s. 155-158
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Konferensbidrag (refereegranskat)abstract
- High Throughput Chip-Level Integration of Communicating Heterogeneous Elements (CLICHÉ) architecture to achieve high performance Networks on Chip (NoC) is proposed. The architecture increases the throughput of the network by 40% while preserving the average latency. The area of High Throughput CLICHÉ switch is decreased by 18% as compared to CLICHÉ switch. The total metal resources required to implement High Throughput CLICHÉ design is increased by 7% as compared to the total metal resources required to implement CLICHÉ design. The extra power consumption required to achieve the proposed architecture is 8% of the total power consumption of the CLICHÉ architecture.
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| 4. |
- Abd El Ghany, M. A., et al.
(författare)
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High throughput architecture for high performance NoC
- 2009
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Ingår i: ISCAS. - : IEEE. - 9781424438280 ; , s. 2241-2244
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Konferensbidrag (refereegranskat)abstract
- High Throughput Butterfly Fat Tree (HTBFT) architecture to achieve high performance Networks on Chip (NoC) is proposed. The architecture increases the throughput of the network by 38% while preserving the average latency. The area of HTBFT switch is decreased by 18% as compared to Butterfly Fat Tree switch. The total metal resources required to implement HTBFT design is increased by 5% as compared to the total metal resources required to implement BFT design. The extra power consumption required to achieve the proposed architecture is 3% of the total power consumption of the BFT architecture.
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| 5. |
- Abd El Ghany, M. A., et al.
(författare)
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Power efficient networks on chip
- 2009
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Ingår i: 2009 16th IEEE International Conference on Electronics, Circuits and Systems, ICECS 2009. - 9781424450916 ; , s. 105-108
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Konferensbidrag (refereegranskat)abstract
- a low power switch design is proposed to achieve power-efficient Network on Chip (NoC). The proposed NoC switch reduce. The power consumption oy the Butterfly Fat Tree (BFT) architecture by 28 % as compared to the conventional BFT switch. Moreover. The power reduction technique is applied to different NoC architectures. The technique reduce. The power consumption oy the network by up to 41%. Whe. The power consumption oy the whole network includin. The interswich links and repeaters is taken into account. The overall power consumption is decreased by up to 33% at the maximum operating frequency oy the switch. The BFT architecture consume. The minimum power as compared to other NoC architectures.
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| 6. |
- Abd Elghany, M. A., et al.
(författare)
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High throughput architecture for OCTAGON network on chip
- 2009
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Ingår i: 2009 16th IEEE International Conference on Electronics, Circuits and Systems, ICECS 2009. - : IEEE. - 9781424450916 ; , s. 101-104
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Konferensbidrag (refereegranskat)abstract
- High Throughput Octagon architecture to achieve high performance Networks on Chip (NoC) is proposed. The architecture increase. The throughput oy the network by 17% while preservin. The average latency. The area of High Throughput OCTAGON switch is decreased by 18% as compared to OCTAGON switch. The total metal resources required to implement High Throughput OCTAGON design is increased by 8% as compared to the total metal resources required to implement OCTAGON design. The extra power consumption required to achiev. The proposed architecture is 2% oy the total power consumption oy the OCTAGON architecture.
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| 7. |
- Fayed, A. A., et al.
(författare)
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A low-voltage, highly linear voltage-controlled transconductor
- 2005
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Ingår i: IEEE transactions on circuits and systems. 2, Analog and digital signal processing (Print). - : Institute of Electrical and Electronics Engineers (IEEE). - 1057-7130 .- 1558-125X. ; 52:12, s. 831-835
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Tidskriftsartikel (refereegranskat)abstract
- A low-voltage fully differential, voltage-controlled transconductor is described. The proposed transconductor achieves a wide input/control voltage range, with a highly linear transconductance factor and truly fully differential output currents. The transconductor is used to implement a G(m)-C adaptive forward equalizer (FE) for a 125 Mbps wire line transceiver using digital core transistors with channel length of no more than double the feature size in a typical digital CMOS 180-nm process and supply voltage as low as 1.6 V. The adaptive FE enables IEEE 1394b transceivers to operate over UTP-5 cables for up to 100 m in length. The transconductor stage occupies 1945 mu m(2) and consumes an average power of 418 mu w at 125 Mbps and 1.8-V supply.
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| 8. |
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| 9. |
- Ola, Thomas O, et al.
(författare)
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Importin beta : A novel autoantigen in human autoimmunity identified by screening random peptide libraries on phage
- 2006
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Ingår i: Journal of Autoimmunity. - : Elsevier BV. - 0896-8411 .- 1095-9157. ; 26:3, s. 197-207
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Tidskriftsartikel (refereegranskat)abstract
- By screening random peptide libraries (RPLs) with sera of Type 1 diabetes (T1D) patients, we previously identified 5 disease-specific 'mimotopes' displayed on phages (phagotopes). We already characterised 1 phagotope (CH1p), as an epitope of human osteopontin, an autoantigen expressed within the somatostatin cells of human islets. In this paper, we report the characterization of the second phagotope, 195Dyn, by immunohistochemistry, Western Blotting and screening of a human islet cDNA library using rabbit anti-195Dyn antibodies. The 195Dyn mimotope was detected in human islets. The screening of a λgt11 cDNA library from human islets has identified a clone, which corresponded to human importin beta. ELISA detected autoantibodies against this protein in sera of around 60% of TD1 patients and in 30% of patients affected by other autoimmune diseases. In summary, RPLs technology proved again successful in identifying another novel autoantigen (importin beta), whose significance in the autoimmune process remains to be fully elucidated. © 2006 Elsevier Ltd. All rights reserved.
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