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Sökning: WFRF:(Moilanen Hannu) > (2018)

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1.
  • Turcot, Valerie, et al. (författare)
  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
  • 2018
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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2.
  • Östbye, Stein, et al. (författare)
  • The creative class : do jobs follow people or do people follow jobs?
  • 2018
  • Ingår i: Regional studies. - : Routledge. - 0034-3404 .- 1360-0591. ; 52:6, s. 745-755
  • Tidskriftsartikel (refereegranskat)abstract
    • Regional adjustment models are applied to explore causal interaction between two types of people distinguished by educational attainment, and two types of jobs, creative class jobs and other jobs. Data used are for labour market regions in Finland, Norway and Sweden from the 2000s. Creative class jobs follow people with high educational attainment (oneway causation), but creative class jobs also follow main jobs and vice versa (circular causation). The results suggest that stimulating creative class job growth could be accomplished through attracting people with higher education, but also through attracting main sector business with the added benefit that the initial stimulus would be reinforced through circular and cumulative causation between job creation in the two sectors.
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