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- Zaborowski, AM, et al.
(författare)
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Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response
- 2022
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Ingår i: The British journal of surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 109:3, s. 251-255
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Tidskriftsartikel (refereegranskat)abstract
- In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.
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- Kovtun, Yurii, et al.
(författare)
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ICRF production of plasma with hydrogen minority in Uragan-2M stellarator by two-strap antenna
- 2024
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Ingår i: Physics of Plasmas. - : American Institute of Physics (AIP). - 1070-664X .- 1089-7674. ; 31:4
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Tidskriftsartikel (refereegranskat)abstract
- The experiments on medium-size stellarator Uragan-2M (U-2M) in Kharkiv, Ukraine, are carried on in support of the Wendelstein 7-X (W7-X) experimental program. The scenario ion cyclotron frequency range (ICRF) plasma production at the hydrogen minority regime had been experimentally tested on U-2M and was qualified at the Large Helical Device (LHD). The paper presents the results of further research on the ICRF plasma production. The ICRF discharge studies were carried out in a H2 + He mixture with a controlled hydrogen concentration ranging from few percents to 75%. The two-strap like antenna mimicks the W7-X antenna operated in monopole phasing. The applied RF power was in the range of ∼100 kW. Relatively dense plasma of up to Ne ∼ 1019 m−3 was produced near the first harmonic of the hydrogen cyclotron frequency. The maximum temperature of the electrons and ions was not more than a few tens of electron volt. The characteristic features of RF plasma production and the propagation of electromagnetic waves in the experimental conditions are discussed. The experiments on U-2M and LHD indicate that the minority scenario of ICRF plasma production appears to be scalable and could be used in large stellarator machines. This is, in particular, important for the future experiments ICRF production of target plasma in W-7X in conditions where electron cyclotron resonance heating start-up is not possible.
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- Moiseenko, Vitali, et al.
(författare)
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A Primer on Dose-Response Data Modeling in Radiation Therapy.
- 2021
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Ingår i: International journal of radiation oncology, biology, physics. - : Elsevier BV. - 1879-355X .- 0360-3016. ; 110:1, s. 11-20
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Tidskriftsartikel (refereegranskat)abstract
- An overview of common approaches used to assess a dose response for radiation therapy-associated endpoints is presented, using lung toxicity data sets analyzed as a part of the High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic effort as an example. Each component presented (eg, data-driven analysis, dose-response analysis, and calculating uncertainties on model prediction) is addressed using established approaches. Specifically, the maximum likelihood method was used to calculate best parameter values of the commonly used logistic model, the profile-likelihood to calculate confidence intervals on model parameters, and the likelihood ratio to determine whether the observed data fit is statistically significant. The bootstrap method was used to calculate confidence intervals for model predictions. Correlated behavior of model parameters and implication for interpreting dose response are discussed.
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