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- Molander, Catrin, 1971, et al.
(författare)
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Sp1 is a key regulator of the PDGF beta-receptor transcription.
- 2001
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Ingår i: Molecular biology reports. - 0301-4851. ; 28:4, s. 223-33
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Tidskriftsartikel (refereegranskat)abstract
- The mouse PDGF beta-receptor promoter is tightly controlled by NF-Y that binds to a CCAAT box located upstream of the initiation site [1, 2]. In this report, we show that Sp1 plays an essential role in the PDGF beta-receptor transcription. Within the upstream GC rich area there are two Sp1 binding sites located in close proximity to the CCAAT box. Deletion of the GC rich region resulted in a 50% decrease of the transcriptional activity of the promoter, and a complete loss of its responsiveness to over-expression of Sp1. There was an additive effect between NF-Y and Sp I in reporter activity when they were co-transfected together with the promoter-reporter construct. Furthermore, transfection of NF-Y failed to enhance transcriptional activity when the Sp1 binding sites were deleted from the promoter, suggesting an important role for Sp1 in this NF-Y controlled transcription. We have recently reported that c-Myc represses PDGF beta-receptor transcription through its interference with the transactivation activity of NF-Y [3]. In the case of p21(wafl/cip1) transcription, c-Myc was shown to repress its transcription by sequestering Sp1 [4]. However, we could not find any effect of Sp1 in the c-Myc-mediated repression on the PFDGF beta-receptor promoter, since the deletion of SpI binding sites could not attenuate the repression by c-Myc on the promoter activity.
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| 3. |
- Molander-Melin, M, et al.
(författare)
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Lipid analyses of human brain rafts
- 2003
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Ingår i: JOURNAL OF NEUROCHEMISTRY. - : Wiley. - 0022-3042 .- 1471-4159. ; 85, s. 34-34
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Molander, Sverker, 1957, et al.
(författare)
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OMNIITOX - operational life-cycle impact assessment models and information tools for practitioners
- 2004
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Ingår i: International Journal of Life Cycle Assessment. - 1614-7502 .- 0948-3349. ; 9:5, s. 282-288
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Tidskriftsartikel (refereegranskat)abstract
- This article is the preamble to a set of articles describing initial results from an on-going European Commission funded, 5th Framework project called OMNIITOX, Operational Models aNd Information tools for Industrial applications of eco/TOXicological impact assessments. The different parts of this case study-driven project are briefly presented and put in relation to the aims of contributing to an operational life cycle-impact assessment (LCIA) model for impacts of toxicants. The present situation has been characterised by methodological difficulties, both regarding choice of the characterisation model(s) and limited input data on chemical properties, which often has resulted in the omission of toxicants from the LCIA, or at best focus on well characterised chemicals. The project addresses both problems and integrates models, as well as data, in an information system- the OMNIITOX IS. There is also a need for clarification of the relations between the (environmental) risk assessments of toxicants and LCIA, in addition to investigating the feasibility of introducing LCA into European chemicals legislation, tasks that also were addressed in the project. Keywords: Case studies; characterisation factor; chemicals; environmental risk assessment; hazard assessment; information system; life cycle impact assessment (LCIA); potentially toxic substances; regulation; risk assessment; risk ranking
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- Nilsson, Lars-Göran, et al.
(författare)
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Betula : a prospective cohort study on memory, health and aging
- 2004
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Ingår i: Aging, Neuropsychology and Cognition. - Hove : Psychology Press. - 1382-5585 .- 1744-4128. ; 11:2-3, s. 134-148
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Tidskriftsartikel (refereegranskat)abstract
- This article describes the Betula Study with respect to objectives, design, participants, and assessment instruments for health and cognition. Three waves of data collection have been completed in 5-year intervals since 1988-1990. A fourth wave started in 2003 and will be completed in 2005. An overview of Betula research is presented under the headings of memory and cognition and cognitive neuroscience. Health-related issues and sex differences as well as comparisons between cross-sectional and longitudinal studies are discussed in the first section. The influence of different genes and of some brain abnormalities for memory functioning in adulthood and old age constitute main topics in the second section. New data are presented on the association between blood pressure and dementia. We demonstrated that a demented group of participants had higher levels of systolic blood pressure and pulse pressure than non-dementia controls 10 years before diagnosis. The new fourth wave of data collection will, in addition to enriching the Betula database, permit revisiting and reanalyzing the existing data from new perspectives.
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