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- Ravaioli, A, et al.
(författare)
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p27 and Skp2 immunoreactivity and its clinical significance with endocrine and chemo-endocrine treatments in node-negative early breast cancer.
- 2008
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Ingår i: Annals of oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 19:4, s. 660-668
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Low p27 and high Skp2 immunoreactivity are associated with a poor prognosis and other poor prognostic features including resistant phenotypes and antiestrogen drug resistance. We investigated these proteins in two International Breast Cancer Study Group trials studying node-negative early breast cancer. PATIENTS AND METHODS: Trial VIII compared chemotherapy followed by goserelin with either modality alone in premenopausal patients. Trial IX compared chemotherapy followed by tamoxifen with tamoxifen alone in postmenopausal patients. Central Pathology Office assessed p27 and Skp2 expression in the primary tumor by immunohistochemistry among 1631 (60%) trial patients. RESULTS: p27 and Skp2 were inversely related; 13% of tumors expressed low p27 and high Skp2. Low p27 and high Skp2 were associated with unfavorable prognostic factors including larger size and higher grade tumors, absence of estrogen receptor and progesterone receptor, human epidermal growth factor receptor 2 overexpression and high Ki-67 (each P < 0.05). Low p27 and high Skp2 were not associated with disease-free survival (P = 0.42 and P = 0.48, respectively). The relative effects of chemo-endocrine versus endocrine therapy were similar regardless of p27 or Skp2. CONCLUSIONS: We confirm the association of low p27 and high Skp2 with other poor prognostic features, but found no predictive or prognostic value, and therefore do not recommend routine determination of p27 and Skp2 for node-negative breast cancer.
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- Razo, M., et al.
(författare)
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Design of hierarchical WDM networks
- 2009
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Ingår i: Network Architectures, Management, and Applications VII. - : SPIE - International Society for Optical Engineering. - 9780819480354 ; , s. 76331I-
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Konferensbidrag (refereegranskat)abstract
- Hierarchical (multi-core) Wavelength Division Multiplexing (WDM) networks present a challenging design problem to the network designer who wishes to establish all-optical circuits end-to-end and across multiple network cores. Due to the nature of the hierarchical structure and its traffi distribution, it is likely that the inner core requires more capacity when compared to the capacity required by the metro cores, which are individually connected to the inner core. This capacity mismatch cannot be addressed by assigning distinct transmission rates to each core, as this solution would result in using electronic time division add-drop multiplexer to interconnect the traffi across cores with distinct rates. An alternative solution to addressing the capacity mismatch between WDM metro and inner core is explored in this paper, which is based on a limited number of wavelengths (a subset of the full set) being used in the metro core, when compared to the full set of wavelengths being used in the inner core. Two available architectures are presented in the paper, discussing their respective advantages and disadvantages.
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