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- Shukla, Lakshmi, et al.
(författare)
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Synthesis and Spectroscopic Properties of Fluorinated Coumarin Lysine Derivatives
- 2018
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 83:8, s. 4792-4799
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Tidskriftsartikel (refereegranskat)abstract
- The site-selective incorporation of fluorescent amino acids into proteins has emerged as a valuable alternative to expressible protein reporters. For successful application, a robust and scalable, yet flexible, route to non-natural amino acids is required. This work describes an improved synthesis of coumarin-conjugated lysine derivatives where fluorinated variants are accessed. These analogues can be utilized at low pH and should find application probing biological processes that operate under acidic conditions.
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