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- Liu, E. J., et al.
(författare)
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Aerial strategies advance volcanic gas measurements at inaccessible, strongly degassing volcanoes
- 2020
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Ingår i: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 6:44
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Tidskriftsartikel (refereegranskat)abstract
- Volcanic emissions are a critical pathway in Earth's carbon cycle. Here, we show that aerial measurements of volcanic gases using unoccupied aerial systems (UAS) transform our ability to measure and monitor plumes remotely and to constrain global volatile fluxes from volcanoes. Combining multi-scale measurements from ground-based remote sensing, long-range aerial sampling, and satellites, we present comprehensive gas fluxes-3760 ± [600, 310] tons day-1 CO2 and 5150 ± [730, 340] tons day-1 SO2-for a strong yet previously uncharacterized volcanic emitter: Manam, Papua New Guinea. The CO2/ST ratio of 1.07 ± 0.06 suggests a modest slab sediment contribution to the sub-arc mantle. We find that aerial strategies reduce uncertainties associated with ground-based remote sensing of SO2 flux and enable near-real-time measurements of plume chemistry and carbon isotope composition. Our data emphasize the need to account for time averaging of temporal variability in volcanic gas emissions in global flux estimates.
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- Jiang, X. T., et al.
(författare)
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Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation
- 2023
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Ingår i: Multiple Sclerosis Journal. - 1352-4585. ; 29:9
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Tidskriftsartikel (refereegranskat)abstract
- Background: The clinical relevance of serum glial fibrillary acidic protein (sGFAP) concentration as a biomarker of MS disability progression independent of acute inflammation has yet to be quantified. Objective: To test whether baseline values and longitudinal changes in sGFAP concentration are associated with disability progression without detectable relapse of magnetic resonance imaging (MRI) inflammatory activity in participants with secondary-progressive multiple sclerosis (SPMS). Methods: We retrospectively analyzed longitudinal sGFAP concentration and clinical outcome data from the Phase 3 ASCEND trial of participants with SPMS, with no detectable relapse or MRI signs of inflammatory activity at baseline nor during the study (n = 264). Serum neurofilament (sNfL), sGFAP, T2 lesion volume, Expanded Disability Status Scale (EDSS), Timed 25-Foot Walk (T25FW), 9-Hole Peg Test (9HPT), and composite confirmed disability progression (CDP) were measured. Linear and logistic regressions and generalized estimating equations were used in the prognostic and dynamic analyses. Results: We found a significant cross-sectional association between baseline sGFAP and sNfL concentrations and T2 lesion volume. No or weak correlations between sGFAP concentration and changes in EDSS, T25FW, and 9HPT, or CDP were observed. Conclusion: Without inflammatory activity, changes in sGFAP concentration in participants with SPMS were neither associated with current nor predictive of future disability progression.
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- Balic, Anamaria, et al.
(författare)
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Extracellular matrix remodelling in dental pulp tissue of carious human teeth through the prism of single-cell RNA sequencing
- 2023
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Ingår i: International Journal of Oral Science. - 2049-3169. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Carious lesions are bacteria-caused destructions of the mineralised dental tissues, marked by the simultaneous activation of immune responses and regenerative events within the soft dental pulp tissue. While major molecular players in tooth decay have been uncovered during the past years, a detailed map of the molecular and cellular landscape of the diseased pulp is still missing. In this study we used single-cell RNA sequencing analysis, supplemented with immunostaining, to generate a comprehensive single-cell atlas of the pulp of carious human teeth. Our data demonstrated modifications in the various cell clusters within the pulp of carious teeth, such as immune cells, mesenchymal stem cells (MSC) and fibroblasts, when compared to the pulp of healthy human teeth. Active immune response in the carious pulp tissue is accompanied by specific changes in the fibroblast and MSC clusters. These changes include the upregulation of genes encoding extracellular matrix (ECM) components, including COL1A1 and Fibronectin (FN1), and the enrichment of the fibroblast cluster with myofibroblasts. The incremental changes in the ECM composition of carious pulp tissues were further confirmed by immunostaining analyses. Assessment of the Fibronectin fibres under mechanical strain conditions showed a significant tension reduction in carious pulp tissues, compared to the healthy ones. The present data demonstrate molecular, cellular and biomechanical alterations in the pulp of human carious teeth, indicative of extensive ECM remodelling, reminiscent of fibrosis observed in other organs. This comprehensive atlas of carious human teeth can facilitate future studies of dental pathologies and enable comparative analyses across diseased organs.
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- Cataldi, Gianni, et al.
(författare)
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Primordial or Secondary? Testing Models of Debris Disk Gas with ALMA*
- 2023
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 951:2
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Tidskriftsartikel (refereegranskat)abstract
- The origin and evolution of gas in debris disks are still not well understood. Secondary gas production from cometary material or a primordial origin have been proposed. So far, observations have mostly concentrated on CO, with only a few C observations available. We overview the C and CO content of debris disk gas and test state-of-the-art models. We use new and archival Atacama Large Millimeter/submillimeter Array (ALMA) observations of CO and C i emission, complemented by C ii data from Herschel, for a sample of 14 debris disks. This expands the number of disks with ALMA measurements of both CO and C i by 10 disks. We present new detections of C i emission toward three disks: HD 21997, HD 121191, and HD 121617. We use a simple disk model to derive gas masses and column densities. We find that current state-of-the-art models of secondary gas production overpredict the C-0 content of debris disk gas. This does not rule out a secondary origin, but might indicate that the models require an additional C removal process. Alternatively, the gas might be produced in transient events rather than a steady-state collisional cascade. We also test a primordial gas origin by comparing our results to a simplified thermochemical model. This yields promising results, but more detailed work is required before a conclusion can be reached. Our work demonstrates that the combination of C and CO data is a powerful tool to advance our understanding of debris disk gas.
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| 7. |
- Cataldi, Gianni, et al.
(författare)
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The Surprisingly Low Carbon Mass in the Debris Disk around HD 32297
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 892:2
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Tidskriftsartikel (refereegranskat)abstract
- Gas has been detected in a number of debris disks. It is likely secondary, i.e., produced by colliding solids. Here, we report ALMA Band 8 observations of neutral carbon in the CO-rich debris disk around the 15-30 Myr old A-type star HD 32297. We find that C-0 is located in a ring at similar to 110 au with an FWHM of similar to 80 au and has a mass of (3.5 0.2) x 10(-3) M-circle plus. Naively, such a surprisingly small mass can be accumulated from CO photodissociation in a time as short as similar to 10(4) yr. We develop a simple model for gas production and destruction in this system, properly accounting for CO self-shielding and shielding by neutral carbon, and introducing a removal mechanism for carbon gas. We find that the most likely scenario to explain both C-0 and CO observations is one where the carbon gas is rapidly removed on a timescale of order a thousand years and the system maintains a very high CO production rate of similar to 15 M-circle plus Myr(-1), much higher than the rate of dust grind-down. We propose a possible scenario to meet these peculiar conditions: the capture of carbon onto dust grains, followed by rapid CO re-formation and rerelease. In steady state, CO would continuously be recycled, producing a CO-rich gas ring that shows no appreciable spreading over time. This picture might be extended to explain other gas-rich debris disks.
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- Gille, Thomas, et al.
(författare)
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The impact of COVID-19 on early career members (ECMs) : an ERS ECM survey
- 2023
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Ingår i: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 62:Supplement 67
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Rationale: COVID-19 pandemic profoundly disorganised healthcare. Respiratory ECMs were at the frontline of the pandemic. The ERS ECM committee assessed the impact of the pandemic on the work and training of ECMs, and compared the differences between the first wave (FW) and subsequent waves (SWs).Methods: An online survey was disseminated via e-mail and social networks to ERS members, with a first round in May 2020, and a second round in October 2021. ECMs (i.e., aged ≤40 years) were asked to participate. The second round incorporated questions about SWs.Results: Eight hundred and forty-four ECMs responded (45% men), of all ages between 18 and 40 years, from 89 countries. They were physicians (48%), registrars/medical students (28%), allied health professionals (8%), full-time researchers (11%), and medical students doing research (5%). During the FW, 64% had to change their working place, opposed to 17% during SWs. More than 50% considered that training/continuous education was altered during all the waves, but more online training was delivered during SWs. Conference attendance was cancelled for 70% during the FW, whereas it was mostly maintained in an online format during SWs. During all the waves, the preferred sources of information were webinars, peer-reviewed journals, and the ERS website. During the FW, 21% of respondents received no mentorship, and 46% received no psychological support. Fifteen percent had to take sick leave for confirmed or suspected COVID-19 and 3% for burnout. Moreover, 54% of research projects were postponed.Conclusion: The pandemic had important consequences on the training and wellbeing of ECMs, with many of them being mobilised for the management of COVID-19 patients.
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- Pagella, Pierfrancesco, 1986-, et al.
(författare)
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A single-cell atlas of human teeth
- 2021
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Ingår i: iScience. - : Cell Press. - 2589-0042. ; 24:5, s. 102405-102405
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Tidskriftsartikel (refereegranskat)abstract
- Teeth exert fundamental functions related to mastication and speech. Despite their great biomedical importance, an overall picture of their cellular and molecular composition is still missing. In this study, we have mapped the transcriptional landscape of the various cell populations that compose human teeth at single-cell resolution, and we analyzed in deeper detail their stem cell populations and their microenvironment. Our study identified great cellular heterogeneity in the dental pulp and the periodontium. Unexpectedly, we found that the molecular signatures of the stem cell populations were very similar, while their respective microenvironments strongly diverged. Our findings suggest that the microenvironmental specificity is a potential source for functional differences between highly similar stem cells located in the various tooth compartments and open new perspectives toward cell-based dental therapeutic approaches.
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| 10. |
- Rebollido, I., et al.
(författare)
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Exocomets: A spectroscopic survey
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 639
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Tidskriftsartikel (refereegranskat)abstract
- Context. While exoplanets are now routinely detected, the detection of small bodies in extrasolar systems remains challenging. Since the discovery of sporadic events, which are interpreted to be exocomets (falling evaporating bodies) around β Pic in the early 1980s, only ∼20 stars have been reported to host exocomet-like events. Aims. We aim to expand the sample of known exocomet-host stars, as well as to monitor the hot-gas environment around stars with previously known exocometary activity. Methods. We have obtained high-resolution optical spectra of a heterogeneous sample of 117 main-sequence stars in the spectral type range from B8 to G8. The data were collected in 14 observing campaigns over the course of two years from both hemispheres. We analysed the Ca » II K&H and Na » I D lines in order to search for non-photospheric absorptions that originated in the circumstellar environment and for variable events that could be caused by the outgassing of exocomet-like bodies. Results. We detected non-photospheric absorptions towards 50% of the sample, thus attributing a circumstellar origin to half of the detections (i.e. 26% of the sample). Hot circumstellar gas was detected in the metallic lines inspected via narrow stable absorptions and/or variable blue- and red-shifted absorption events. Such variable events were found in 18 stars in the Ca » II and/or Na » I lines; six of them are reported in the context of this work for the first time. In some cases, the variations we report in the Ca » II K line are similar to those observed in β Pic. While we do not find a significant trend in the age or location of the stars, we do find that the probability of finding CS gas in stars with larger v sin i is higher. We also find a weak trend with the presence of near-infrared excess and with anomalous (λ Boo-like) abundances, but this would require confirmation by expanding the sample.
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