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- Hering, Bernhard J., et al.
(författare)
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Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
- 2006
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Ingår i: Nature Medicine. - : Nature Publishing Group. - 1078-8956 .- 1546-170X. ; 12:3, s. 301-303
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Tidskriftsartikel (refereegranskat)abstract
- Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of cultured islets from genetically unmodified pigs without Gal-specific antibody manipulation. Immunotherapy with CD25-specific and CD154-specific monoclonal antibodies, FTY720 (or tacrolimus), everolimus and leflunomide suppressed indirect activation of T cells, elicitation of non-Gal pig-specific IgG antibody, intragraft expression of proinflammatory cytokines and invasion of infiltrating mononuclear cells into islets.
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- Moran, Kari, et al.
(författare)
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Frequency Resolution of a Multi Degree of Freedom Resonator
- 2009
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Ingår i: 2009 IEEE Sensors. ; , s. 865-868
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Konferensbidrag (refereegranskat)abstract
- This paper outlines the process for estimating measurable parameters in a multi degree of freedom micro resonator. Thermal mechanical noise provides a baseline limit for frequency resolution of micro resonators. We develop the likelihood function for a linear regression model of 2 degree of freedom resonator. Using the Cramer-Rao inequality we determine the minimum possible covariance to estimate parameters, such as the natural frequency of the system.
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