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Sökning: WFRF:(Morel Alexandra) > (2016)

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  • Baraldi, Enrico, et al. (författare)
  • Exploring the obstacles to implementing economic mechanisms to stimulate antibiotic research and development : a mulit-actor and system-level analysis
  • 2016
  • Ingår i: American Journal of Law & Medicine. - Boston : Boston University School of Law. - 0098-8588 .- 2375-835X. ; 42, s. 451-486
  • Tidskriftsartikel (refereegranskat)abstract
    • This Article examines the potential stakeholder-related obstacles hindering the implementation of mechanisms to re-ignite the development of novel antibiotics. Proposed economic models and incentives to drive such development include: Public Funding of Research and Development (R&D), Tax Incentives, Milestone Prizes, End Payments, Intellectual Property (IP) and Exclusivity Extensions, Pricing and Reimbursement Incentives, Product Development Partnerships (PDPs), and the Options Market for Antibiotics model. Drawing on personal experience and understanding of the antibiotic field, as well as stakeholder consultation and numerous expert meetings within the DRIVE-AB project and Uppsala Health Summit 2015, the Authors identify obstacles attributable to the following actors: Universities and Research Institutes, Small and Medium-sized Enterprises (SMEs), Large Pharmaceutical Companies, Marketing Approval Regulators, Payors, Healthcare Providers, National Healthcare Authorities, Patients, and Supranational Institutions. The analysis also proposes a characterization and ranking of the difficulty associated with implementing the reviewed mechanisms. Public Funding of R&D, Pricing and Reimbursement Incentives, and PDPs are mechanisms expected to meet highly systemic barriers (i.e., obstacles across the entire antibiotic value chain), imposing greater implementation challenges in that they require convincing and involving several motivationally diverse actors in order to have much effect.
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