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- Artzi-Medvedik, Rada, et al.
(författare)
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Quality of Life and Kidney Function in Older Adults : Prospective Data of the SCOPE Study
- 2023
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Ingår i: Journal of Clinical Medicine. - 2077-0383. ; 12:12
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Tidskriftsartikel (refereegranskat)abstract
- A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS) at baseline and at one and two years after recruitment. A full comprehensive geriatric assessment was performed, including sociodemographic and clinical characteristics, the Geriatric Depression Scale-Short Form (GDS-SF), Short Physical Performance Battery (SPPB), and estimated glomerular filtration rate (eGFR). The association between EQ-VAS decline and covariates was investigated by multivariable analyses. A total of 41% of the participants showed EQ-VAS decline, and 16.3% showed kidney function decline over the two-year follow-up period. Participants with EQ-VAS decline showed an increase in GDS-SF scores and a greater decline in SPPB scores. The logistic regression analyses showed no contribution of a decrease in kidney function on EQ-VAS decline in the early stages of CKD. However, older adults with a greater GDS-SF score were more likely to present EQ-VAS decline over time, whereas an increase in the SPPB scores was associated with less EQ-VAS decline. This finding should be considered in clinical practice and when HRQoL is used to evaluate health interventions among older adults.
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| 2. |
- García-Moreno, Carlos D., et al.
(författare)
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La necrópolis de la ampliación del Museo Nacional de Arte Romano (Mérida, Badajoz) : estudio antropológico y contexto funerario [The necropolis of “la ampliación del Museo Nacional de Arte Romano” (Mérida, Badajoz): anthropological study and funerary context]
- 2023
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Ingår i: SAGVNTVM. Papeles del Laboratorio de Arqueología de Valencia. - 0210-3729 .- 2174-517X. ; 55, s. 215-234
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Tidskriftsartikel (refereegranskat)abstract
- We present the study of the skeletons found on the site of La ampliacion del Museo Nacional de Arte Romano (Merida, Badajoz). We address palaeodemography (by estimating sex and age), chronology (by means of C-14 dating in bone) and taphonomy, with special attention to preservation, comparing it with the funerary context. The total number of individuals identified is at least 118. The high number of non-adults (n=41) suggests a high infant mortality rate, coinciding with other nearby contemporary necropolises. The remains are relatively well preserved, with no differential distribution by sex/age. The predominant orientation is SW-NE and a single supine grave. Thirteen burials contained nails, either due to the presence of a wooden box or small boxes as grave goods. Radiocarbon dating of two tombs provided a Low-Imperial-Tard-Ancient chronology (3(rd)-6(th) centuries AD). Similarities can be observed between all the funerary areas of Augusta Emerita, showing a possible pattern of funerary context.
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| 3. |
- Hess, Timo, et al.
(författare)
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Dissecting the genetic heterogeneity of gastric cancer
- 2023
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 92
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Tidskriftsartikel (refereegranskat)abstract
- Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture.Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO.Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level.Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular mechanisms underlying cardia GC and OAC/BO.
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