| 1. |
|
|
| 2. |
- Bravo, L, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 3. |
- Tabiri, S, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- El Kharraz, S., et al.
(författare)
-
The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation
- 2021
-
Ingår i: Embo Reports. - : EMBO. - 1469-221X .- 1469-3178. ; 22:12
-
Tidskriftsartikel (refereegranskat)abstract
- Whereas dimerization of the DNA-binding domain of the androgen receptor (AR) plays an evident role in recognizing bipartite response elements, the contribution of the dimerization of the ligand-binding domain (LBD) to the correct functioning of the AR remains unclear. Here, we describe a mouse model with disrupted dimerization of the AR LBD (AR(Lmon/Y)). The disruptive effect of the mutation is demonstrated by the feminized phenotype, absence of male accessory sex glands, and strongly affected spermatogenesis, despite high circulating levels of testosterone. Testosterone replacement studies in orchidectomized mice demonstrate that androgen-regulated transcriptomes in AR(Lmon/Y) mice are completely lost. The mutated AR still translocates to the nucleus and binds chromatin, but does not bind to specific AR binding sites. In vitro studies reveal that the mutation in the LBD dimer interface also affects other AR functions such as DNA binding, ligand binding, and co-regulator binding. In conclusion, LBD dimerization is crucial for the development of AR-dependent tissues through its role in transcriptional regulation in vivo. Our findings identify AR LBD dimerization as a possible target for AR inhibition.
|
|
| 7. |
|
|
| 8. |
- Lo Bello, L., et al.
(författare)
-
Schedulability analysis of Time-Sensitive Networks with scheduled traffic and preemption support
- 2020
-
Ingår i: Journal of Parallel and Distributed Computing. - : Academic Press Inc.. - 0743-7315 .- 1096-0848. ; 144, s. 153-171
-
Tidskriftsartikel (refereegranskat)abstract
- The Time-Sensitive Networking (TSN) set of standards introduces in IEEE 802.1 switches and end stations novel features to meet the requirements of a broad spectrum of applications that are characterized by time-sensitive and mission-critical traffic flows. In particular, the IEEE802.1Qbv-2015 amendment introduces enhancements that provide temporal isolation for scheduled traffic, i.e., a traffic class that requires transmission based on a known timescale, while the IEEE802.1Qbu-2016 introduces preemption as a mechanism to allow time-critical messages to interrupt ongoing non time-critical transmissions. Both amendments, that are now enrolled in the IEEE802.1Q-2018 standard, are very important for industrial networks, where scheduled traffic and low-latency real-time flows have to coexist, on the same network, with best-effort transmissions. In this context, this work presents a response time analysis of TSN networks that encompasses the enhancements for scheduled traffic and preemption, in various combinations. The paper presents the proposed analysis and a performance comparison between the response times calculated by the analysis and the response times obtained through OMNeT++ simulations in three different scenarios. © 2020 Elsevier Inc.
|
|
| 9. |
|
|
