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- Carpten, JD, et al.
(författare)
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HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome
- 2002
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 32:4, s. 676-680
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Tidskriftsartikel (refereegranskat)abstract
- We report here the identification of a gene associated with the hyperparathyroidism-jaw tumor (HPT-JT) syndrome. A single locus associated with HPT-JT (HRPT2) was previously mapped to chromosomal region 1q25-q32. We refined this region to a critical interval of 12 cM by genotyping in 26 affected kindreds. Using a positional candidate approach, we identified thirteen different heterozygous, germline, inactivating mutations in a single gene in fourteen families with HPT-JT. The proposed role of HRPT2 as a tumor suppressor was supported by mutation screening in 48 parathyroid adenomas with cystic features, which identified three somatic inactivating mutations, all located in exon 1. None of these mutations were detected in normal controls, and all were predicted to cause deficient or impaired protein function. HRPT2 is a ubiquitously expressed, evolutionarily conserved gene encoding a predicted protein of 531 amino acids, for which we propose the name parafibromin. Our findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT-JT and in development of some sporadic parathyroid tumors.
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- Edman, Ludvig, 1967-, et al.
(författare)
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Influence of the anion on the kinetics and stability of a light-emitting electrochemical cell
- 2003
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Ingår i: Synthetic metals. - : Elsevier. - 0379-6779 .- 1879-3290. ; 138:3, s. 441-446
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Tidskriftsartikel (refereegranskat)abstract
- The selection of the anion is shown to be crucial for the response time and the lifetime of light-emitting electrochemical cells (LECs) fabricated with [co-block phenyl-substituted poly(para phenylene vinylene)]-PEO-LiX (X = Tf, TFSI, Tf-TFSI). With a mixed-anion (X = Tf-TFSI) salt. the LEC turned on in less than 0.4 s at ΔU = 4.0 V, with X = TFS1 it turned on in a few seconds, while X = Tf produced devices with significantly larger response times with a strong dependence on the film thickness. We attribute this significant variation in the response to the morphology of the PEO-LiX phase at room temperature: PEO-LiTf is largely crystalline with a correspondingly limited ionic mobility: PEO-LiTf-TFSI is amorphous with a relatively high mobility; and heat-treated PEO-LiTFSI is typically partially amorphous. For lifetimes. we focused on 3.0 ≤ ΔU ≤ 4.0 V since this range coincided with a crossover in performance for the X = Tf devices. At ΔU = 3.0 V, these lasted the entire measurement cycle (=55 h) with constant efficiency and only a small decrease in light output. At ΔU ≥ 3.25 V. the same devices exhibited a limited lifetime with a linear dependence on the salt concentration and a decrease in the efficiency with time. For X = TFSI. Tf-TFSI short lifetimes and a decrease in efficiency with time were obtained independent of the applied voltage. Considering recently published data on electrochemical stability, we propose that an irreversible overreduction of the anion is a significant side reaction that limits the lifetime of LEC systems.
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- Edman, Ludvig, 1967-, et al.
(författare)
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Single-component light-emitting electrochemical cell with improved stability
- 2003
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Ingår i: Applied Physics Letters. - : American Institute of Physics (AIP). - 0003-6951 .- 1077-3118. ; 82:22, s. 3961-3963
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Tidskriftsartikel (refereegranskat)abstract
- We report a single-component polymeric light-emitting electrochemical cell with poly[9,9'-bis[6"-(N, N, N-trimethylammonium)hexyl]fluorene-alt-co-phenylene]bromide (PFN+Br-) as the active material. Indium tin oxide/PFN+Br-/aluminum sandwich structures demonstrate a low and thickness-independent turn-on voltage (2.9 V) for blue light emission. Thermophysical characterization shows that PFN+Br- is in a metastable amorphous phase after spin casting, but that crystallization takes place at elevated temperatures. With this information at hand, we allowed devices to turn-on via ionic redistribution (and the formation of a p-i-n junction) in the amorphous phase, and then stabilized this desired configuration through crystallization. We find significantly improved lifetimes and relatively fast turn-on times for these single-component devices operating at room temperature.
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- Heeger, Alan J, et al.
(författare)
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Injection lasers fabricated from semiconducting polymers
- 2004
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Patent (populärvet., debatt m.m.)abstract
- A solid state lasing structure comprising a field effect transistor in which source and drain electrodes are disposed on a semiconducting light emitting organic polymer forming an active layer on a gate whereby current between the source and drain electrodes defines and flows along a channel in the active layer to define a recombination and emission zone
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