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The roles of an alu...
The roles of an aluminum underlayer in the biocompatibility and mechanical integrity of vertically aligned carbon nanotubes for interfacing with retinal neurons
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- Watterson, William J. (författare)
- University of Oregon
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- Moslehi, Saba (författare)
- University of Oregon
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- Rowland, Conor (författare)
- University of Oregon
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- Zappitelli, Kara M. (författare)
- University of Oregon
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- Smith, Julian H. (författare)
- University of Oregon
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- Miller, David (författare)
- University of Oregon
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- Chouinard, Julie E. (författare)
- University of Oregon
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- Golledge, Stephen L. (författare)
- University of Oregon
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- Taylor, Richard P. (författare)
- University of Oregon
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- Perez, Maria Thereza (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Nanomaterial för retinala implantat,Forskargrupper vid Lunds universitet,Other operations, LTH,Faculty of Engineering, LTH,Nanomaterials for retinal prostheses,Lund University Research Groups
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- Alemán, Benjamín J. (författare)
- University of Oregon
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(creator_code:org_t)
- 2020
- 2020
- Engelska.
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Ingår i: Micromachines. - 2072-666X. ; 11:6
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Retinal implant devices are becoming an increasingly realizable way to improve the vision of patients blinded by photoreceptor degeneration. As an electrode material that can improve restored visual acuity, carbon nanotubes (CNTs) excel due to their nanoscale topography, flexibility, surface chemistry, and double-layer capacitance. If vertically aligned carbon nanotubes (VACNTs) are biocompatible with retinal neurons and mechanically robust, they can further improve visual acuity-most notably in subretinal implants-because they can be patterned into high-aspect-ratio, micrometer-size electrodes. We investigated the role of an aluminum (Al) underlayer beneath an iron (Fe) catalyst layer used in the growth of VACNTs by chemical vapor deposition (CVD). In particular, we cultured dissociated retinal cells for three days in vitro (DIV) on unfunctionalized and oxygen plasma functionalized VACNTs grown from a Fe catalyst (Fe and Fe + Pl preparations, where Pl signifies the plasma functionalization) and an Fe catalyst with an Al underlayer (Al/Fe and Al/Fe + Pl preparations). The addition of the Al layer increased the mechanical integrity of the VACNT interface and enhanced retinal neurite outgrowth over the Fe preparation. Unexpectedly, the extent of neurite outgrowth was significantly greater in the Al/Fe than in the Al/Fe+Pl preparation, suggesting plasma functionalization can negatively impact biocompatibility for some VACNT preparations. Additionally, we show our VACNT growth process for the Al/Fe preparation can support neurite outgrowth for up to 7 DIV. By demonstrating the retinal neuron biocompatibility, mechanical integrity, and pattern control of our VACNTs, this work offers VACNT electrodes as a solution for improving the restored visual acuity provided by modern retinal implants.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Biomaterials
- Cell culture
- Glia
- Retinal implants
- Retinal neurons
- VACNTs
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- art (ämneskategori)
- ref (ämneskategori)
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Watterson, Willi ...
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Moslehi, Saba
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Rowland, Conor
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Zappitelli, Kara ...
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Smith, Julian H.
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Miller, David
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visa fler...
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Chouinard, Julie ...
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Golledge, Stephe ...
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Taylor, Richard ...
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Perez, Maria The ...
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Alemán, Benjamín ...
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visa färre...
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TEKNIK OCH TEKNO ...
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