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Geographical variab...
Geographical variability and environmental risk factors in inflammatory bowel disease
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- Ng, Siew C. (author)
- Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Inst Digest Dis, Chinese Univ, Hong Kong, China
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- Bernstein, Charles N. (author)
- Dept Internal Med, IBD Clin & Res Ctr, University Manitoba, Winnipeg MB, Canada
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- Vatn, Morten H. (author)
- Dept Gastroenterol, Inst Clin Med, EpiGen, University of Oslo, Oslo, Norway
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- Lakatos, Peter Laszlo (author)
- Dept Med 1, Semmelweis University, Budapest, Hungary
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- Loftus, Edward V., Jr. (author)
- Div Gastroenterol & Hepatol, Mayo Clin, Rochester MN, USA
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- Tysk, Curt, 1949- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Dept Gastroenterol
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- O'Morain, Colm (author)
- Dept Gastroenterol, Adelaide & Meath Hosp, Trinity Coll Dublin, Dublin, Ireland
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- Moum, Björn (author)
- Dept Gastroenterol, University of Oslo Hosp, Oslo, Norway; Inst Clin Med, University of Oslo, Oslo, Norway
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- Colombel, Jean-Frederic (author)
- Div Gastroenterol, Mt Sinai Sch Med, New York NY, USA
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(creator_code:org_t)
- 2013-01-18
- 2013
- English.
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In: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 62:4, s. 630-649
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The changing epidemiology of inflammatory bowel disease (IBD) across time and geography suggests that environmental factors play a major role in modifying disease expression. Disease emergence in developing nations suggests that epidemiological evolution is related to westernisation of lifestyle and industrialisation. The strongest environmental associations identified are cigarette smoking and appendectomy, although neither alone explains the variation in incidence of IBD worldwide. Urbanisation of societies, associated with changes in diet, antibiotic use, hygiene status, microbial exposures and pollution have been implicated as potential environmental risk factors for IBD. Changes in socioeconomic status might occur differently in different geographical areas and populations and, consequently, it is important to consider the heterogeneity of risk factors applicable to the individual patient. Environmental risk factors of individual, familial, community-based, country-based and regionally based origin may all contribute to the pathogenesis of IBD. The geographical variation of IBD provides clues for researchers to investigate possible environmental aetiological factors. The present review aims to provide an update of the literature exploring geographical variability in IBD and to explore the environmental risk factors that may account for this variability.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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- art (subject category)
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Ng, Siew C.
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Bernstein, Charl ...
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Vatn, Morten H.
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Lakatos, Peter L ...
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Loftus, Edward V ...
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Tysk, Curt, 1949 ...
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O'Morain, Colm
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Moum, Björn
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Colombel, Jean-F ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Gut
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Örebro University