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Intrahepatic Fat an...
Intrahepatic Fat and Postprandial Glycemia Increase After Consumption of a Diet Enriched in Saturated Fat Compared With Free Sugars
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- Parry, Sion A. (författare)
- Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Rosqvist, Fredrik, 1985- (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
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- Mozes, Ferenc E. (författare)
- Univ Oxford, John Radcliffe Hosp, Oxford Ctr Clin Magnet Resonance Res, Oxford, England.
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- Cornfield, Thomas (författare)
- Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Hutchinson, Matthew (författare)
- Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Piche, Marie-Eve (författare)
- Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Laval Univ, Quebec Heart & Lung Inst, Quebec City, PQ, Canada.
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- Huelsmeier, Andreas J. (författare)
- Univ Hosp Zurich, Inst Clin Chem, Zurich, Switzerland.;Univ Zurich, Zurich, Switzerland.
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- Hornemann, Thorsten (författare)
- Univ Hosp Zurich, Inst Clin Chem, Zurich, Switzerland.;Univ Zurich, Zurich, Switzerland.
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- Dyson, Pamela (författare)
- Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Oxford Univ Hosp Trusts, Natl Inst Hlth Res Oxford Biomed Res Ctr, Oxford, England.
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- Hodson, Leanne (författare)
- Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Oxford Univ Hosp Trusts, Natl Inst Hlth Res Oxford Biomed Res Ctr, Oxford, England.
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Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England Klinisk nutrition och metabolism (creator_code:org_t)
- 2020-03-12
- 2020
- Engelska.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 43:5, s. 1134-1141
- Relaterad länk:
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https://care.diabete...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
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- OBJECTIVE Debate continues regarding the influence of dietary fats and sugars on the risk of developing metabolic diseases, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). We investigated the effect of two eucaloric diets, one enriched with saturated fat (SFA) and the other enriched with free sugars (SUGAR), on intrahepatic triacylglycerol (IHTAG) content, hepatic de novo lipogenesis (DNL), and whole-body postprandial metabolism in overweight males.RESEARCH DESIGN AND METHODS Sixteen overweight males were randomized to consume the SFA or SUGAR diet for 4 weeks before consuming the alternate diet after a 7-week washout period. The metabolic effects of the respective diets on IHTAG content, hepatic DNL, and whole-body metabolism were investigated using imaging techniques and metabolic substrates labeled with stable-isotope tracers.RESULTS Consumption of the SFA diet significantly increased IHTAG by mean +/- SEM 39.0 +/- 10.0%, while after the SUGAR diet IHTAG was virtually unchanged. Consumption of the SFA diet induced an exaggerated postprandial glucose and insulin response to a standardized test meal compared with SUGAR. Although whole-body fat oxidation, lipolysis, and DNL were similar following the two diets, consumption of the SUGAR diet resulted in significant (P < 0.05) decreases in plasma total, HDL, and non-HDL cholesterol and fasting beta-hydroxybutyrate plasma concentrations.CONCLUSIONS Consumption of an SFA diet had a potent effect, increasing IHTAG together with exaggerating postprandial glycemia. The SUGAR diet did not influence IHTAG and induced minor metabolic changes. Our findings indicate that a diet enriched in SFA is more harmful to metabolic health than a diet enriched in free sugars.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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Parry, Sion A.
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Rosqvist, Fredri ...
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Mozes, Ferenc E.
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Cornfield, Thoma ...
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Hutchinson, Matt ...
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Piche, Marie-Eve
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Huelsmeier, Andr ...
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Hornemann, Thors ...
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Dyson, Pamela
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Hodson, Leanne
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Diabetes Care
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Uppsala universitet