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Clozapine but not l...
Clozapine but not lithium reverses aberrant tyrosine uptake in patients with bipolar disorder
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- Tabrisi, Reza, 1982- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Plastic Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Harun-Rashid, M. D. (författare)
- Karolinska Institutet
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- Johansson, Jessica, 1977- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper
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- Venizelos, Nikolaos, Professor, 1946- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Msghina, Mussie, 1959- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Psychiatry, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- Springer, 2023
- 2023
- Engelska.
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Ingår i: Psychopharmacology. - : Springer. - 0033-3158 .- 1432-2072. ; 240:8, s. 1667-1676
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- RATIONALE: Availability of the dopamine and noradrenaline precursor tyrosine is critical for normal functioning, and deficit in tyrosine transport across cell membrane and the blood-brain barrier has been reported in bipolar disorder and schizophrenia. Clozapine and lithium are two psychoactive agents used to treat psychosis, mood disorders and suicidal behavior, but their mechanism of action remains largely unknown.OBJECTIVE: To characterize immediate and delayed differences in tyrosine uptake between healthy controls (HC) and bipolar patients (BP) and see if these differences could be normalized by either clozapine, lithium or both. A second objective was to see if clozapine and lithium have additive, antagonistic or synergistic effects in this.METHOD: Fibroblasts from five HC and five BP were incubated for 5 min or 6 h with clozapine, lithium, or combination of both. Radioactive labelled tyrosine was used to quantify tyrosine membrane transport.RESULTS: There was significantly reduced tyrosine uptake at baseline in BP compared to HC, a deficit that grew with increasing incubation time. Clozapine selectively increased tyrosine uptake in BP and abolished the deficit seen under baseline conditions, while lithium had no such effect. Combination treatment with clozapine and lithium was less effective than when clozapine was used alone.CONCLUSIONS: There was significant deficit in tyrosine transport in BP compared to HC that was reversed by clozapine but not lithium. Clozapine was more effective when used alone than when added together with lithium. Potential clinical implications of this will be discussed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Bipolar disorder
- Clozapine
- Dopamine
- Fibroblasts
- Lithium
- Noradrenaline
- Pathophysiology
- Tyrosine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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