| 1. |
- Krege, Susanne, et al.
(författare)
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European consensus conference on diagnosis and treatment of germ cell cancer: A report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): Part I
- 2008
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Ingår i: European Urology. - : Elsevier BV. - 1873-7560 .- 0302-2838. ; 53:3, s. 478-496
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Forskningsöversikt (refereegranskat)abstract
- Objectives: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. Methods: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
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| 2. |
- Krege, Susanne, et al.
(författare)
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European consensus conference on diagnosis and treatment of germ cell cancer: A report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): Part II
- 2008
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Ingår i: European Urology. - : Elsevier BV. - 1873-7560 .- 0302-2838. ; 53:3, s. 497-513
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Forskningsöversikt (refereegranskat)abstract
- Objectives: The first consensus report that had been presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, The Netherlands. Methods: Medical oncologists, urologic surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference and incorporated the new data into updated and revised guidelines. As for the first meeting the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The second part of the consensus paper includes the treatment of metastasised disease, residual tumour resection, salvage therapy, follow-up, and late toxicities. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early-stage as well as of advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. in addition, the particular needs of testicular cancer survivors have been acknowledged. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
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| 3. |
- Abdallah, J., et al.
(författare)
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Masses, lifetimes and production rates of Xi(-) and Xi(+) at LEP 1
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 639:3-4, s. 179-191
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of the Xi(-) and (Xi) over bar (+) masses, mass differences, lifetimes and lifetime differences are presented. The (Xi) over bar (+) sample used is much larger than those used previously for such measurements. In addition, the S production rates in Z -> b (b) over bar and Z -> q (q) over bar events are compared and the position xi* of the maximum of the distribution in Z -> q (q) over bar events is measured.
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| 4. |
- Akhoondi, Shahab, et al.
(författare)
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FBXW7/hCDC4 is a general tumor suppressor in human cancer
- 2007
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 67:19, s. 9006-9012
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Tidskriftsartikel (refereegranskat)abstract
- The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins, which are substrate recognition components of the multisubunit ubiquitin ligase SCF (Skpl-Cdc53/ Cullin-F-box-protein), has been shown to mediate the ubiquitin-dependent proteolysis of several oncoproteins including cyclin El, c-Myc, c-Jun, and Notch. The oncogenic potential of Fbxw7 substrates, frequent allelic loss in human cancers, and demonstration that mutation of FBXW7 cooperates with p53 in mouse tumorigenesis have suggested that Fbxw7 could function as a tumor suppressor in human cancer. Here, we carry out an extensive genetic screen of primary tumors to evaluate the role of FBXW7 as a tumor suppressor in human tumorigenesis. Our results indicate that FBXW7 is inactivated by mutation in diverse human cancer types with an overall mutation frequency of ∼ 6%. The highest mutation frequencies were found in tumors of the bile duct (cholangio-carcinomas, 35%), blood (T-cell acute lymphocytic leukemia, 31%), endometrium (9%), colon (9%), and stomach (6%). Approximately 43% of all mutations occur at two mutational "hotspots," which alter Arg residues (Arg465 and Arg479) that are critical for substrate recognition. Furthermore, we show that Fbxw7Arg465 hotspot mutant can abrogate wild-type Fbxw7 function through a dominant negative mechanism. Our study is the first comprehensive screen of FBXW7 mutations in various human malignancies and shows that FBXW7 is a general tumor suppressor in human cancer.
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| 5. |
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| 6. |
- Grahn, Maria, 1963, et al.
(författare)
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Fuel and Vehicle Technology Choices for Passenger Vehicles in Achieving Stringent CO2 Targets: Connections between Transportation and Other Energy Sectors
- 2009
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Ingår i: Environmental Science and Technology. - 1382-3124. ; 43:9, s. 3365-3371
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Tidskriftsartikel (refereegranskat)abstract
- The regionalized Global Energy Transition (GET-R 6.0) modelhas been modified to include a detailed description of light-duty vehicle options and used to investigate the potential impact of carbon capture and storage (CCS) and concentrating solar power (CSP) on cost-effective fuel/vehicle technologies in a carbon-constrained world. Total CO2 emissions were constrained to achieve stabilization at 400-550 ppm, by 2100, at lowest total system cost. The dominant fuel/vehicle technologies varied significantly depending on CO2 constraint, future cost of vehicle technologies, and availability of CCS and CSP. For many cases, no one technology dominated on a global scale. CCS provides relatively inexpensive low-CO2 electricity and heat which prolongs the use of traditional ICEVs. CSP displaces fossil fuel derived electricity, prolongs the use of traditional ICEVs, and promotes electrification of passenger vehicles. In all cases considered, CCS and CSP availability had a major impact on the lowest cost fuel/vehicle technologies, and alternative fuels are needed in response to expected dwindling oil and natural gas supply potential by the end of the century.
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| 7. |
- He, Zeming, et al.
(författare)
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Effect of ceramic dispersion on thermoelectric properties of nano ZrO2/CoSb3 composites
- 2007
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 101:4, s. 043707-
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Tidskriftsartikel (refereegranskat)abstract
- In the present work, nano- ZrO2 CoSb3 composites were fabricated by milling ZrO2 and CoSb3 powders and hot pressing at different sintering temperatures. For the prepared compacts, the phase purity, microstructure, and temperature-dependent thermoelectric properties were characterized. The effect of nano- ZrO2 dispersion on composite electrical conductivity and thermal conductivity is strictly clarified by comparing the transport properties of the nondispersed and dispersed CoSb3 at identical porosity, so that the effect of porosity on thermoelectric parameters could be eliminated. The effect of the insulating inclusion itself on transport properties is also considered and eliminated using effective media theories. It is clearly verified that charge carrier scattering and phonon scattering occur simultaneously to lower the electrical conductivity and the thermal conductivity of CoSb3 due to the introduction of nano- ZrO2 inclusions. The investigated composites show higher electrical conductivity due to existence of metallic Sb and lower thermal conductivity because of nanodispersion. At the ranges of high measuring temperature (673-723 K) and low porosity (6%-9%), the ratio of electrical conductivity to thermal conductivity of the dispersed CoSb3 is higher than that of nondispersed CoSb3, and the dimensionless figure of merit (ZT) of the composite could probably be improved at these ranges with the enhanced ratio of electrical conductivity to thermal conductivity and Seebeck coefficient, which is assumed to be increased by a potential barrier scattering.
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| 8. |
- He, Zeming, et al.
(författare)
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Nano ZrO2/CoSb3 composites with improved thermoelectric figure of merit
- 2007
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Ingår i: Nanotechnology. - : IOP Publishing. - 0957-4484 .- 1361-6528. ; 18:23, s. 235602-
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Tidskriftsartikel (refereegranskat)abstract
- Nano ZrO2/CoSb3 composites with different ZrO 2 contents were prepared using hot pressing. The phase purity, the microstructure and the temperature-dependent transport parameters of the composites were investigated. The dimensionless figure of merit (ZT) of 0.18 of the non-dispersed CoSb3 preponderates the maximal value (0.17) of pure CoSb3 reported in the literature, which is attributed to the prepared sample having higher electrical conductivity due to the existence of a small amount of metallic Sb and lower thermal conductivity due to the fine-grained structure. Compared to non-dispersed CoSb3, a further improvement of 11% on ZT (0.20) was achieved in the composite with 0.05ZrO 2 inclusions, which resulted from the enhanced ratio of electrical conductivity to thermal conductivity and the Seebeck coefficient. The nanodispersion method provides an effective approach to improving a material's thermoelectric properties and performance.
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| 9. |
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| 10. |
- Kjellman, Arne, et al.
(författare)
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Open Peer Commentaries
- 2008
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Ingår i: Constructivist Foundations. - : ALEXANDER RIEGLER. - 1782-348X. ; 3:2, s. 65-108
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Open peer commentary on the target article "Who Conceives of Society?" by Ernst von Glasersfeld. First paragraph: Ernst von Glasersfeld sets out to explain how familiar patterns (signs) arise in private experience - and how they are extracted or " recognized" as such. These patterns are recursive, which imposes significance (familiarity) on them, and are, in the course of time, collected into a " bulk of experience." I think a convinced constructivist can - if hesitantly - accept his rendering, even though it is one that lacks the stringency one expects from a supposedly natural scientist ( 46). However, the crucial point is that this paper does not address the convinced constructivist but rather the opposite camps, and I doubt he succeeds in convincing them.
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