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- Mulligan, Joseph, et al.
(författare)
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An ‘engineer-client’ framework for community participation in infrastructure development projects
- 2011
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Ingår i: Proceedings of the Institution of Civil Engineers. - : Thomas Telford Ltd.. - 1478-4637 .- 1751-7664 .- 1478-4629 .- 1751-7680.
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Tidskriftsartikel (refereegranskat)abstract
- The importance of community participation in projects in the developing and developed world is widely recognised, despite considerable debate regarding what participation means in practice. In the developing world context, there is a distinct debate on how participation can achieve its stated goals of creating ‘ownership’ among targeted beneficiaries without becoming susceptible to elite capture or excluding marginalised groups. Projects that involve engineering analysis present a further challenge: to incorporate external technical expertise in decision-making so that project outcomes are improved, without compromising the participative process. The paper sets out a practical framework that reconciles the critical importance of early, meaningful community involvement in decision-making with the active role of the engineer as a technical adviser and facilitator. It is targeted for application in community-scale infrastructure development projects, where the community is the primary targeted beneficiary. The framework draws a parallel with a traditional engineer–client relationship, in which the client's (in this case the community's) needs and preferences drive the design process and in which final design approval rests with the client, but where the engineer plays an active role in helping to understand and interpret the client's needs and develops engineering responses through an iterative, responsive design process.
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- Osorio, Ana, et al.
(författare)
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DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
- 2014
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 10:4
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Tidskriftsartikel (refereegranskat)abstract
- Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p<0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03-1.16), p = 2.7×10-3) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95%CI: 1.03-1.21, p = 4.8×10-3). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied.
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