| 1. |
- Zaborowski, AM, et al.
(författare)
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Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response
- 2022
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Ingår i: The British journal of surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 109:3, s. 251-255
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Tidskriftsartikel (refereegranskat)abstract
- In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.
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| 2. |
- Adriani, O., et al.
(författare)
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Design of an Antimatter Large Acceptance Detector In Orbit (ALADInO)
- 2022
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Ingår i: Instruments. - : MDPI AG. - 2410-390X. ; 6:2
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Tidskriftsartikel (refereegranskat)abstract
- A new generation magnetic spectrometer in space will open the opportunity to inves-tigate the frontiers in direct high-energy cosmic ray measurements and to precisely measure the amount of the rare antimatter component in cosmic rays beyond the reach of current missions. We propose the concept for an Antimatter Large Acceptance Detector In Orbit (ALADInO), designed to take over the legacy of direct measurements of cosmic rays in space performed by PAMELA and AMS-02. ALADInO features technological solutions conceived to overcome the current limi-tations of magnetic spectrometers in space with a layout that provides an acceptance larger than 10 m2 sr. A superconducting magnet coupled to precision tracking and time-of-flight systems can provide the required matter–antimatter separation capabilities and rigidity measurement resolution with a Maximum Detectable Rigidity better than 20 TV. The inner 3D-imaging deep calorimeter, designed to maximize the isotropic acceptance of particles, allows for the measurement of cosmic rays up to PeV energies with accurate energy resolution to precisely measure features in the cosmic ray spectra. The operations of ALADInO in the Sun–Earth L2 Lagrangian point for at least 5 years would enable unique revolutionary observations with groundbreaking discovery poten-tials in the field of astroparticle physics by precision measurements of electrons, positrons, and antiprotons up to 10 TeV and of nuclear cosmic rays up to PeV energies, and by the possible unam-biguous detection and measurement of low-energy antideuteron and antihelium components in cosmic rays.
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| 3. |
- Marcelli, N., et al.
(författare)
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Helium Fluxes Measured by the PAMELA Experiment from the Minimum to the Maximum Solar Activity for Solar Cycle 24
- 2022
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Ingår i: Astrophysical Journal Letters. - : IOP Publishing Ltd. - 2041-8205 .- 2041-8213. ; 925:2
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Tidskriftsartikel (refereegranskat)abstract
- Time-dependent energy spectra of galactic cosmic rays (GCRs) carry fundamental information regarding their origin and propagation. When observed at the Earth, these spectra are significantly affected by the solar wind and the embedded solar magnetic field that permeates the heliosphere, changing significantly over an 11 yr solar cycle. Energy spectra of GCRs measured during different epochs of solar activity provide crucial information for a thorough understanding of solar and heliospheric phenomena. The PAMELA experiment collected data for almost 10 years (2006 June 15-2016 January 23), including the minimum phase of solar cycle 23 and the maximum phase of solar cycle 24. In this paper, we present new spectra for helium nuclei measured by the PAMELA instrument from 2010 January to 2014 September over a three-Carrington-rotation time basis. These data are compared to the PAMELA spectra measured during the previous solar minimum, providing a picture of the time dependence of the helium-nuclei fluxes over a nearly full solar cycle. Time and rigidity dependencies are observed in the proton-to-helium flux ratios. The force-field approximation of the solar modulation was used to relate these dependencies to the shapes of the local interstellar proton and helium-nuclei spectra.
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