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- Babulal, Ganesh M, et al.
(författare)
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Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.
- 2019
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 15:2, s. 292-312
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise "state-of-the-science" report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.
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- Cadar, Dorina, et al.
(författare)
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Does education explain the terminal decline in the oldest-old? Evidence from two longitudinal studies of ageing
- 2015
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Ingår i: The Lancet. - 0140-6736. ; 386:Supplement 2
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- AbstractBackground Cognitive performance substantially deteriorates close to death, as postulated by the terminal decline hypothesis. However, the association between education and terminal decline remains controversial. This study investigated the role of education in terminal decline in two European longitudinal studies of oldest-old. Methods Participants were from the Newcastle 85+, UK (n=702), and Octogenarian Twins (OCTO-Twin), Sweden (n= 845). They were assessed biannually over three and five consecutive waves, respectively. In a coordinated analysis, multilevel models were used to examine the association between education and terminal decline on mini-mental state examination (MMSE), controlling for age at baseline, dementia incidence, sex, and time to death from the study entry within each cohort. Cognitive decline was modelled as a linear function of time to death in both cohorts and as a quadratic function in the OCTO-Twin study (because of longer follow-up). Education was a continuous measure (ranging from 6 to 20 years in Newcastle 85+ and 0 to 23 years in OCTO-Twin). Findings A typical British man, aged 85 at baseline, with 10 years’ education, entered the terminal phase at around 2·5 years before death, and the mean rate of decline was −1·04 MMSE points with each year closer to the time of death (SEM 0·25, p<0·0001). By contrast, a Swedish man, aged 83 years, with an average of 7 years’ education, entered the terminal phase at around 8 years from death, after which the rate of cognitive decline steepened by −1·70 points per year closer to the time of death (SEM 0·20, p<0·0001) and accelerated by −0·11 (SEM 0·01, p<0·0001). Education was positively associated with the estimated mean MMSE scores before death only in OCTO-Twin (0·43, SEM 0·15; p=0·003) and did not attenuate the rate of terminal decline in either cohort. Interpretation Decline and acceleration of this decline were detectable in both studies before death, with steeper rates of decline observed in the Swedish cohort. However, this process was not lessened by education itself. This work contributes to a better understanding of the transition from the subtle cognitive changes associated with age to those of neurological substance, and the role of education in this decline. Funding The funding sources of this work were the Alzheimer's Society (grant number 144) and the Medical Research Council (unit programme number MC_UU_12019/1).
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- Cadar, Dorina, et al.
(författare)
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The role of cognitive reserve on terminal decline: a cross-cohort analysis from two European studies: OCTO-Twin, Sweden, and Newcastle 85+, UK.
- 2016
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Ingår i: International journal of geriatric psychiatry. - : Wiley. - 1099-1166 .- 0885-6230. ; 31:6, s. 601-610
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Tidskriftsartikel (refereegranskat)abstract
- Cognitive performance shows a marked deterioration in close proximity to death, as postulated by the terminal decline hypothesis. The effect of education on the rate of terminal decline in the oldest people (i.e. persons 85+ years) has been controversial and not entirely understood. In the current study, we investigated the rate of decline prior to death with a special focus on the role of education and socioeconomic position, in two European longitudinal studies of ageing: the Origins of Variance in the Old-Old: Octogenarian Twins (OCTO-Twin) and the Newcastle 85+ study.
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- Robitaille, Annie, et al.
(författare)
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Latent growth models matched to research questions to answer questions about dynamics of change in multiple processes.
- 2017
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Ingår i: Journal of clinical epidemiology. - : Elsevier BV. - 1878-5921 .- 0895-4356. ; 82, s. 158-166
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Tidskriftsartikel (refereegranskat)abstract
- Given theoretical and methodological advances that propose hypothesis about change in one or multiple processes, analytical methods for longitudinal data have been developed that provide researchers with various options for analyzing change over time. In this paper, we revisit several latent growth curve models that may be considered to answer questions about repeated measures of continuous variables, which may be operationalised as time varying covariates or outcomes.To illustrate each of the models discussed and how to interpret parameter estimates, we present examples of each method discussed using cognitive and blood pressure measures from a longitudinal study of ageing, the OCTO Twin Study.Although statistical models are helpful tools to test theoretical hypotheses about the dynamics between multiple processes, the choice of model and its specification will influence results and conclusions made.
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