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| 2. |
- Bjørnsbo, Kirsten Schroll, et al.
(författare)
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Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort
- 2024
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Ingår i: BMJ Open. - 2044-6055. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Introduction The population-based Inter99 cohort has contributed extensively to our understanding of effects of a systematic screening and lifestyle intervention, as well as the multifactorial aetiology of type 2 diabetes (T2D) and cardiovascular disease. To understand causes, trajectories and patterns of early and overt cardiometabolic disease manifestations, we will perform a combined clinical deep phenotyping and registry follow-up study of the now 50–80 years old Inter99 participants. Methods and analysis The Inter99 cohort comprises individuals aged 30–60 years, who lived in a representative geographical area of greater Copenhagen, Denmark, in 1999. Age-stratified and sex-stratified random subgroups were invited to participate in either a lifestyle intervention (N=13 016) or questionnaires (N=5264), while the rest served as a reference population (N=43 021). Of the 13 016 individuals assigned to the lifestyle intervention group, 6784 (52%) accepted participation in a baseline health examination in 1999, including screening for cardiovascular risk factors and prediabetic conditions. In total, 6004 eligible participants, who participated in the baseline examination, will be invited to participate in the deep phenotyping 20-year follow-up clinical examination including measurements of anthropometry, blood pressure, arterial stiffness, cardiometabolic biomarkers, coronary artery calcification, heart rate variability, heart rhythm, liver stiffness, fundus characteristics, muscle strength and mass, as well as health and lifestyle questionnaires. In a subsample, 10-day monitoring of diet, physical activity and continuous glucose measurements will be performed. Fasting blood, urine and faecal samples to be stored in a biobank. The established database will form the basis of multiple analyses. A main purpose is to investigate whether low birth weight independent of genetics, lifestyle and glucose tolerance predicts later common T2D cardiometabolic comorbidities. Ethics and dissemination The study was approved by the Medical Ethics Committee, Capital Region, Denmark (H-20076231) and by the Danish Data Protection Agency through the Capital Region of Denmark’s registration system (P-2020-1074). Informed consent will be obtained before examinations. Findings will be disseminated in peer-reviewed journals, at conferences and via presentations to stakeholders, including patients and public health policymakers.
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| 3. |
- Czolkos, Ilja, et al.
(författare)
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Prediction of wastewater quality using amperometric bioelectronic tongues
- 2016
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Ingår i: Biosensors & bioelectronics. - : Elsevier. - 0956-5663 .- 1873-4235. ; 75, s. 375-382
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Tidskriftsartikel (refereegranskat)abstract
- Wastewater samples from a Swedish chemi-thermo-mechanical pulp (CTMP) mill collected at different purification stages in a wastewater treatment plant (WWTP) were analyzed with an amperometric enzyme-based biosensor array in a flow-injection system. In order to resolve the complex composition of the wastewater, the array consists of several sensing elements which yield a multidimensional response. We used principal component analysis (PCA) to decompose the array's responses, and found that wastewater with different degrees of pollution can be differentiated. With the help of partial least squares regression (PLS-R), we could link the sensor responses to the Microtox (R) toxicity parameter, as well as to global organic pollution parameters (COD, BOD, and TOC). From investigating the influences of individual sensors in the array, it was found that the best models were in most cases obtained when all sensors in the array were included in the PLS-R model. We find that fast simultaneous determination of several global environmental parameters characterizing wastewaters is possible with this kind of biosensor array, in particular because of the link between the sensor responses and the biological effect onto the ecosystem into which the wastewater would be released. In conjunction with multivariate data analysis tools, there is strong potential to reduce the total time until a result is yielded from days to a few minutes. (C) 2015 Elsevier B.V. All rights reserved.
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| 4. |
- Nord, Lars, 1958-, et al.
(författare)
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Conclusion : Nordic political communication between change and continuity
- 2021
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Ingår i: Power, Communication and Politics in the Nordic countries. - Gothenburg : Nordicom. - 9789188855282 ; , s. 385-396
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Bokkapitel (refereegranskat)abstract
- The overall conclusion that can be drawn from the contributions in this anthol-ogy is that it is hardly relevant to talk about a clear-cut Nordic model of political communication that highly contrasts other democratic states and their political communication systems. Global trends such as digitalisation and commercialisa-tion of media systems and blurring lines between national and global political issues influence political communication. Still, there are many observations that confirm the existence of prevailing Nordic system peculiarities, such as compara-bly higher levels of voter turnout and political trust and relatively strong private and public news media. While these merging characteristics exist, it is relevant to look more carefully upon factors in the Nordic countries that seem to contribute to continuity and stability in political communication systems. In our view, it is particularly interesting to pay attention to relevant factors in the Nordic countries that may contribute to resilience in these societies. So far, the Nordic countries have shown considerable ability to embrace international political communication trends without jeopardising essential nation-specific distinctive features. Whether this resilience will prevail in the future remains an open question.
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| 5. |
- Nørgaard, Bjarne L, et al.
(författare)
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Risk prediction in acute coronary syndrome from serial in-hospital measurements of N-terminal pro-B-type natriuretic peptide.
- 2008
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Ingår i: Acute cardiac care. - : Informa UK Limited. - 1748-2941 .- 1748-295X. ; 10:3, s. 159-66
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Tidskriftsartikel (refereegranskat)abstract
- There is limited information about the in-hospital plasma profile of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with non-ST-elevation acute coronary syndrome (NSTACS) and furthermore, the prognostic influence of the timing of NT-proBNP measurements in NSTACS is unsettled. These subject matters are elucidated in this study composed of 455 patients with NSTACS (symptoms <24 h). NT-proBNP was measured at 0, 6, 12, 24, 36, 48, 72 and 96 h following admission. Any death was registered at follow-up (median: 2.3 years). The study demonstrated a monophasic profile of the plasma NT-proBNP values, reaching a maximum at 6 hours, and it showed an independent prognostic significance of NT-proBNP irrespective of the sampling time. Risk prediction by NT-proBNP was improved by combining the baseline measurement and one value taken between 24 and 96 h (at 48 h, P<0.001). No additional prognostic information was provided by including more than one late in-hospital NT-proBNP value. Conclusions: The in-hospital NT-proBNP measurements exhibit a monophasic profile in patients with NSTACS and these values provide independent prognostic information as regards mortality irrespective of the sampling time. Moreover, risk prediction of NT-proBNP is strengthened by combining the admission measurement with an additional value during the hospitalization.
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| 6. |
- Nørgaard, Jens Peter, et al.
(författare)
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Antidiuresis therapy: Mechanism of action and clinical implications
- 2007
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Ingår i: Neurourology and Urodynamics. - : Wiley. - 0733-2467 .- 1520-6777. ; 26:7, s. 1008-1013
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Tidskriftsartikel (refereegranskat)abstract
- Abnormalities of micturition occur in many different diseases, have a variety of causes and take several forms. This review will focus exclusively on those abnormalities in which antidiuretic therapy may be of benefit. These conditions are primarily characterized by an increase in the total amount of urine produced (polyuria) or a circadian shift in the control of urine production and/or voiding (nocturnal enuresis, nocturia).
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| 7. |
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| 8. |
- Oldgren, Jonas, et al.
(författare)
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Myocardial Damage, Inflammation and Thrombin Inhibition in Unstable Coronary Artery Disease
- 2003
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Ingår i: European Heart Journal. - 0195-668X .- 1522-9645. ; 24:1, s. 86-93
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Tidskriftsartikel (refereegranskat)abstract
- AIM:Unstable coronary artery disease (CAD) is a multifactorial disease involving both thrombotic and inflammatory processes. We have assessed the time-course and the influence of thrombin inhibitors on changes in fibrinogen and C-reactive protein levels, and their relation to myocardial ischaemia in unstable CAD.METHODS AND RESULTS:Three hundred and twenty patients were randomized to 72 h infusion with three different doses of inogatran, a direct thrombin inhibitor, or unfractionated heparin. There were no significant differences between the treatment groups in fibrinogen or C-reactive protein levels. Overall, the fibrinogen levels were significantly increased in the first 24-96 h and still elevated at 30 days. The C-reactive protein levels showed a more pronounced increase during the first 24-96 h, but then markedly decreased over 30 days. Troponin-positive compared to troponin-negative patients had higher fibrinogen and C-reactive protein levels up to 96 h, although there was an increase compared to pre-treatment levels in both groups. A high fibrinogen level (pre-treatment top tertile) was associated with an increased rate of death or myocardial (re-)infarction at 30 days, 13% vs 5.6%, P=0.03, and increased long-term mortality. A high C-reactive protein level was related to increased 30-day mortality, 4% vs 0%, P=0.01.CONCLUSION:Myocardial cell injury was related to a high degree of inflammation, only some of which is an acutephase response due to tissue damage. The rise in fibrinogen was sustained, which might reflect low grade inflammation with long-term risk of thrombosis. The transient elevation of C-reactive protein levels might indicate a propensity to a pronounced inflammatory response and is associated with increased mortality.
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| 9. |
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Power, Communication, and Politics in the Nordic countries
- 2021
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- The Nordic countries are stable democracies with solid infrastructures for political dialogue and negotiations. However, both the “Nordic model” and Nordic media systems are under pressure as the conditions for political communication change – not least due to weakened political parties and the widespread use of digital communication media. In this anthology, the similarities and differences in political communication across the Nordic countries are studied. Traditional corporatist mechanisms in the Nordic countries are increasingly challenged by professionals such as lobbyists, a development that has consequences for the processes and forms of political communication. Populist political parties have increased their media presence and political influence, whereas the news media have lost readers, viewers, listeners, and advertisers. These developments influence societal power relations and restructure the ways in which political actors communicate about political issues. This book is a key reference for all who are interested in current trends and developments in the Nordic countries. The editors, Eli Skogerbø, Øyvind Ihlen, Nete Nørgaard Kristensen, and Lars Nord, have published extensively on political communication, and the authors are all scholars based in the Nordic countries with specialist knowledge in their fields.
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| 10. |
- Skogerbö, Eli, et al.
(författare)
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Introduction : A Nordic model for political communication?
- 2021
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Ingår i: Power, Communication, and Politics in ther Nordic Countries. - Gothenburg : Nordicom. - 9789188855282 ; , s. 13-28
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Bokkapitel (refereegranskat)abstract
- The Nordic countries have been termed a supermodel for political and economic governance. This anthology explores how and why the political communication systems contribute to explaining and understanding why the Nordic countries stand out as stable, democratic welfare states. The state and nation-building processes of these small European countries were not at all identical, but the ensuing political systems show many similarities. Yet, there are also considerable differences. Part One of the anthology explores developments in the media structure and relation-ship between media and politics in the five Nordic countries. The chapters are co-authored by scholars from political communication, media, and journalism from each country and emphasise particular national traits. Part Two studies and compares political communication across the Nordic countries within particular domains, such as political journalism, local journalism, lobbyism, elections, and the spread of fake news, with a specific eye for similarities and differences between the Nordic countries. We conclude with the argument that Nordic political communi-cation is and should be international and comparative. Still we want to highlight the need to also continue with in-depth national or Nordic comparative studies.
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