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- Nakamura, R, et al.
(författare)
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Substorm observations in the early morning sector with Equator-S and Geotail
- 1999
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Ingår i: Annales Geophysicae. - : SPRINGER VERLAG. - 0992-7689 .- 1432-0576. ; 17:12, s. 1602-1610
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Tidskriftsartikel (refereegranskat)abstract
- Data from Equator-S and Geotail are used to study the dynamics of the plasma sheet observed during a substorm with multiple intensifications on 25 April 1998, when both spacecraft were located in the early morning sector (03-04 MLT) at a radial distance o
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- Pulkkinen, TI, et al.
(författare)
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Two substorm intensifications compared: Onset, expansion, and global consequences
- 1998
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Ingår i: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - : AMER GEOPHYSICAL UNION. ; 103:A1, s. 15-27
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We present observations of two sequential substorm onsets on May 15, 1996. The first event occurred during persistently negative IMF B-Z, whereas the second expansion followed a northward turning of the interplanetary magnetic field (IMF). While the first
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- Sasada, T., et al.
(författare)
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Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II)
- 1999
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Ingår i: Free Radical Biology & Medicine. - : Elsevier. - 0891-5849 .- 1873-4596. ; 27:5-6, s. 504-514
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Tidskriftsartikel (refereegranskat)abstract
- The thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control. In this study, we investigated the relationship between intracellular TRXR levels and cellular sensitivity to cis-diamminedichloroplatinum (II) (CDDP). HeLa, a human cervical carcinoma cell line, cultured with CDDP showed a time- and dose-dependent reduction of intracellular TRXR activity, which was well correlated with the decrease in cell viability after exposure to CDDP. In a cell-free system, CDDP was found to directly inactivate the reduced form of purified human TRXR. The CDDP-resistant variants of HeLa cells, established by continuous exposure to CDDP, exhibited an increased expression and activity of TRXR as well as TRX compared with the parental cells. In addition, sodium selenate, an inhibitor of TRXR, was found to increase the susceptibility to CDDP in the CDDP-resistant cells. Moreover, the HeLa cells transfected with an antisense TRXR RNA expression vector to reduce the intracellular enzyme activity displayed an enhanced sensitivity to CDDP. Taken together with previous reports on TRX, these results indicate the possible involvement of TRXR as well as TRX in the cellular sensitivity and resistance to CDDP.
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