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Träfflista för sökning "WFRF:(Nakashima E) srt2:(2010-2014)"

Sökning: WFRF:(Nakashima E) > (2010-2014)

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2.
  • Cho, Yoon Shin, et al. (författare)
  • Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
  • 2012
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.
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3.
  • Sato, T., et al. (författare)
  • Evaluation of dose rate reduction in a spacecraft compartment due to additional water shield
  • 2011
  • Ingår i: Cosmic Research (English translation of Kosimicheskie Issledovaniya). - 0010-9525 .- 1608-3075. ; 49:4, s. 319-324
  • Tidskriftsartikel (refereegranskat)abstract
    • The dose reduction rates brought about by the installation of additional water shielding in a spacecraft are calculated in the paper using the particles and heavy ion transport code system PHITS, which can deal with transport of all kinds of hadrons and heavy ions with energies up to 100 GeV/n in three-dimensional phase spaces. In the PHITS simulation, an imaginary spacecraft was irradiated isotropically by cosmic rays with charges up to 28 and energies up to 100 GeV/n, and the dose reduction rates due to water shielding were evaluated for 5 types of doses: the dose equivalents obtained from the LET and linear energy spectra, the dose equivalents to skin and red bone marrow, and the effective dose equivalent. The results of the simulation indicate that the dose reduction rates differ according to the type of dose evaluated. For example, 5 g/cm(2) water shielding reduces the effective dose equivalent and the LET dose equivalent by approximately 14% and 32%, respectively. Such degrees of dose reduction can be regarded to make water shielding worth the efforts required to install it.
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