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An Exercise Interve...
An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women : Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants
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Goedecke, Julia H. (författare)
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Mendham, Amy E. (författare)
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Clamp, Louise (författare)
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Nankam, Pamela A. Nono (författare)
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Fortuin-de Smidt, Melony C. (författare)
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Phiri, Lindokuhle (författare)
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Micklesfield, Lisa K. (författare)
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Keswel, Dheshnie (författare)
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Woudberg, Nicholas J. (författare)
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Lecour, Sandrine (författare)
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Alhamud, Ali (författare)
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Kaba, Mamadou (författare)
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Lutomia, Faith M. (författare)
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van Jaarsveld, Paul J. (författare)
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de Villiers, Anniza (författare)
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Kahn, Steven E. (författare)
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- Chorell, Elin, 1981- (författare)
- Umeå universitet,Medicin
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- Hauksson, Jon (författare)
- Umeå universitet,Radiofysik
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- Olsson, Tommy (författare)
- Umeå universitet,Medicin
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(creator_code:org_t)
- 2018-04-18
- 2018
- Engelska.
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Ingår i: JMIR Research Protocols. - : JMIR PUBLICATIONS, INC. - 1929-0748. ; 7:4
- Relaterad länk:
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https://doi.org/10.2...
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https://umu.diva-por... (primary) (Raw object)
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https://www.research...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
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- Background: The pathogenesis of type 2 diabetes (T2D) in black African women is complex and differs from that in their white counterparts. However, earlier studies have been cross-sectional and provide little insight into the causal pathways. Exercise training is consistently used as a model to examine the mechanisms underlying insulin resistance and risk for T2D.Objective: The objective of the study was to examine the mechanisms underlying the changes in insulin sensitivity and secretion in response to a 12-week exercise intervention in obese black South African (SA) women.Methods: A total of 45 obese (body mass index, BMI: 30-40 kg/m2) black SA women were randomized into a control (n=22) or experimental (exercise; n=23) group. The exercise group completed 12 weeks of supervised combined aerobic and resistance training (40-60 min, 4 days/week), while the control group maintained their typical physical activity patterns, and both groups were requested not to change their dietary patterns. Before and following the 12-week intervention period, insulin sensitivity and secretion (frequently sampled intravenous glucose tolerance test) and its primary and secondary determinants were measured. Dietary intake, sleep quality and quantity, physical activity, and sedentary behaviors were measured every 4 weeks.Results: The final sample included 20 exercise and 15 control participants. Baseline sociodemographics, cardiorespiratory fitness, anthropometry, cardiometabolic risk factors, physical activity, and diet did not differ between the groups (P>.05).Conclusions: The study describes a research protocol for an exercise intervention to understand the mechanisms underlying insulin sensitivity and secretion in obese black SA women and aims to identify causal pathways underlying the high prevalence of insulin resistance and risk for T2D in black SA women, targeting specific areas for therapeutic intervention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- diabetes mellitus type 2
- insulin resistance
- body fat distribution
- adipose tissue
- skeletal muscle
- gastrointestinal microbiome
- exercise
- fatty liver
- inflammation
- energy metabolism
- cardiorespiratory fitness
- lipids
- metabolomics
- fatty acids
- diet records
- mitochondria
- ectopic fat
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Goedecke, Julia ...
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Mendham, Amy E.
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Clamp, Louise
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Nankam, Pamela A ...
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Fortuin-de Smidt ...
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Phiri, Lindokuhl ...
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visa fler...
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Micklesfield, Li ...
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Keswel, Dheshnie
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Woudberg, Nichol ...
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Lecour, Sandrine
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Alhamud, Ali
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Kaba, Mamadou
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Lutomia, Faith M ...
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van Jaarsveld, P ...
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de Villiers, Ann ...
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Kahn, Steven E.
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Chorell, Elin, 1 ...
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Hauksson, Jon
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Olsson, Tommy
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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JMIR Research Pr ...
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Umeå universitet