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Lanreotide Autogel ...
Lanreotide Autogel 120 mg at extended dosing intervals in patients with acromegaly biochemically controlled with octreotide LAR : the LEAD study
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- Neggers, Sebastian J C M M (författare)
- Department of Endocrinology Erasmus Medical Center, Rotterdam, Netherlands et al
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- Pronin, Vyacheslav (författare)
- 1Department of Endocrinology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
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- Balcere, Inga (författare)
- Department of Endocrinology, Pauls Stradins Clinical University Hospital, Riga, Latvia
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- Lee, Moon-Kyu (författare)
- Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea
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- Rozhinskaya, Liudmila (författare)
- Department of Neuroendocrinology and Bone Diseases, National Endocrinology Research Centre, Moscow, Russian Federation
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- Bronstein, Marcello D (författare)
- Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil
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- Gadelha, Mônica R (författare)
- Endocrine Section, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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- Maisonobe, Pascal (författare)
- Boulogne-Billancourt, Ipsen, Boulogne-Billancourt, France
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- Sert, Caroline (författare)
- Boulogne-Billancourt, Ipsen, Boulogne-Billancourt, France
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- van der Lely, Aart Jan (författare)
- Department of Endocrinology, Erasmus Medical Center, Rotterdam, Netherlands
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Department of Endocrinology Erasmus Medical Center, Rotterdam, Netherlands et al 1Department of Endocrinology, IM. Sechenov First Moscow State Medical University, Moscow, Russian Federation (creator_code:org_t)
- 2015
- 2015
- Engelska.
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Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 173:3
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- OBJECTIVE: To evaluate extended dosing intervals (EDIs) with lanreotide Autogel 120 mg in patients with acromegaly previously biochemically controlled with octreotide LAR 10 or 20 mg.DESIGN AND METHODS: Patients with acromegaly had received octreotide LAR 10 or 20 mg/4 weeks for ≥ 6 months and had normal IGF1 levels. Lanreotide Autogel 120 mg was administered every 6 weeks for 24 weeks (phase 1); depending on week-24 IGF1 levels, treatment was then administered every 4, 6 or 8 weeks for a further 24 weeks (phase 2). Hormone levels, patient-reported outcomes and adverse events were assessed.PRIMARY ENDPOINT: proportion of patients on 6- or 8-week EDIs with normal IGF1 levels at week 48 (study end).RESULTS: 107/124 patients completed the study (15 withdrew from phase 1 and two from phase 2). Of 124 patients enrolled, 77.4% were allocated to 6- or 8-week EDIs in phase 2 and 75.8% (95% CI: 68.3-83.3) had normal IGF1 levels at week 48 with the EDI (primary analysis). A total of 88.7% (83.1-94.3) had normal IGF1 levels after 24 weeks with 6-weekly dosing. GH levels were ≤ 2.5 μg/l in > 90% of patients after 24 and 48 weeks. Patient preferences for lanreotide Autogel 120 mg every 4, 6 or 8 weeks over octreotide LAR every 4 weeks were high.CONCLUSIONS: Patients with acromegaly achieving biochemical control with octreotide LAR 10 or 20 mg/4 weeks are possible candidates for lanreotide Autogel 120 mg EDIs. EDIs are effective and well received among such patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Neggers, Sebasti ...
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Pronin, Vyachesl ...
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Balcere, Inga
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Lee, Moon-Kyu
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Rozhinskaya, Liu ...
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Bronstein, Marce ...
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Gadelha, Mônica ...
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Maisonobe, Pasca ...
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Sert, Caroline
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van der Lely, Aa ...
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