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Träfflista för sökning "WFRF:(Nevalainen J.) srt2:(2005-2009)"

Sökning: WFRF:(Nevalainen J.) > (2005-2009)

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2.
  • Minkkilä, Anna, et al. (författare)
  • The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
  • 2009
  • Ingår i: European Journal of Medicinal Chemistry. - Paris : Édifor. - 0223-5234 .- 1768-3254. ; 44:7, s. 2994-3008
  • Tidskriftsartikel (refereegranskat)abstract
    • A series of para-substituted phenolic N-alkyl carbamates were evaluated for their FAAH and MGL inhibitory activities. The compounds were generally selective for FAAH, with IC50 values in the nM range, whereas inhibition of MGL required concentrations three orders of magnitude higher. The most potent compounds, dodecylcarbamic acid 4-(4,5-dihydrothiazol-2-yl)phenyl (12) and 4-(1,2,3-thiadiazol-4-yl)phenyl (26) esters, inhibited FAAH and MGL with IC50 values at the low-nanomolar (IC50s; 0.0063 and 0.012 μM) and the low-micromolar ranges (IC50s; 2.1 and 1.0 μM), respectively. Compound 26 also inhibited both FAAH-dependent AEA uptake and AEA hydrolysis (IC50; 0.082 μM) by intact RBL2H3 cells, and could also reduce 2-AG hydrolysis by these cells at concentrations ≥0.030 μM.
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3.
  • Nevalainen, H., et al. (författare)
  • Firing of coal and biomass and their mixtures in 50 kW and 12 MW circulating fluidized beds - Phenomenon study and comparison of scales
  • 2007
  • Ingår i: Fuel. - : Elsevier BV. - 0016-2361. ; 86:14, s. 2043-2051
  • Tidskriftsartikel (refereegranskat)abstract
    • The combustion dynamics of coal, wood chips and their mixture is investigated. Load change capability and the effect of the individual control variables, for example the mixture ratio of different fuels, on pilot-scale CFB boiler dynamics were also studied. Disturbances in fuel feeding cause fluctuations in the flue gas concentrations. Changes in the heating value are possible due to varying moisture content of the fuel. Both these disturbances affect the instantaneous firing rate in a boiler. Also the characteristics of the fuels have to be taken into consideration when designing boiler control systems. When co-firing two fuels with clearly distinct combustion characteristics, direct assumptions based on each fuel's characteristies cannot be made about combustion behaviour of their mixture. Combustion experiments with coal and wood chips and their co-firing were carried out in a pilot-scale CFB reactor (VTT) and a large-scale CFB boiler (Chalmers). A comparison of the combustion in the two different size reactors, provides information about scaling. The combustion responses due to changes in the fuel feeding of the two circulating fluidized beds are analyzed by a dynamic model. (c) 2007 Elsevier Ltd. All rights reserved.
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