| 1. |
- Akkoyun, S., et al.
(författare)
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AGATA - Advanced GAmma Tracking Array
- 2012
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 0167-5087 .- 1872-9576. ; 668, s. 26-58
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Tidskriftsartikel (refereegranskat)abstract
- The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation γ-ray spectrometer. AGATA is based on the technique of γ-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a γ ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of γ-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector- response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. © 2011 Elsevier B.V. All rights reserved.
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| 2. |
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| 3. |
- Ngo, H. Q., et al.
(författare)
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Multipair Full-Duplex Relaying With Massive Arrays and Linear Processing
- 2014
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Ingår i: IEEE Journal on Selected Areas in Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 0733-8716 .- 1558-0008. ; 32:9, s. 1721-1737
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Tidskriftsartikel (refereegranskat)abstract
- We consider a multipair decode-and-forward relay channel, where multiple sources transmit simultaneously their signals to multiple destinations with the help of a full-duplex relay station. We assume that the relay station is equipped with massive arrays, while all sources and destinations have a single antenna. The relay station uses channel estimates obtained from received pilots and zero-forcing (ZF) or maximum-ratio combining/maximum-ratio transmission (MRC/MRT) to process the signals. To significantly reduce the loop interference effect, we propose two techniques: i) using a massive receive antenna array; or ii) using a massive transmit antenna array together with very low transmit power at the relay station. We derive an exact achievable rate expression in closed-form for MRC/MRT processing and an analytical approximation of the achievable rate for ZF processing. This approximation is very tight, particularly for a large number of relay station antennas. These closed-form expressions enable us to determine the regions where the full-duplex mode outperforms the half-duplex mode, as well as to design an optimal power allocation scheme. This optimal power allocation scheme aims to maximize the energy efficiency for a given sum spectral efficiency and under peak power constraints at the relay station and sources. Numerical results verify the effectiveness of the optimal power allocation scheme. Furthermore, we show that, by doubling the number of transmit/receive antennas at the relay station, the transmit power of each source and of the relay station can be reduced by 1.5 dB if the pilot power is equal to the signal power, and by 3 dB if the pilot power is kept fixed, while maintaining a given quality of service.
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| 4. |
- Pagan, C, et al.
(författare)
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The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders.
- 2014
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Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Elevated whole-blood serotonin and decreased plasma melatonin (a circadian synchronizer hormone that derives from serotonin) have been reported independently in patients with autism spectrum disorders (ASDs). Here, we explored, in parallel, serotonin, melatonin and the intermediate N-acetylserotonin (NAS) in a large cohort of patients with ASD and their relatives. We then investigated the clinical correlates of these biochemical parameters. Whole-blood serotonin, platelet NAS and plasma melatonin were assessed in 278 patients with ASD, their 506 first-degree relatives (129 unaffected siblings, 199 mothers and 178 fathers) and 416 sex- and age-matched controls. We confirmed the previously reported hyperserotonemia in ASD (40% (35-46%) of patients), as well as the deficit in melatonin (51% (45-57%)), taking as a threshold the 95th or 5th percentile of the control group, respectively. In addition, this study reveals an increase of NAS (47% (41-54%) of patients) in platelets, pointing to a disruption of the serotonin-NAS-melatonin pathway in ASD. Biochemical impairments were also observed in the first-degree relatives of patients. A score combining impairments of serotonin, NAS and melatonin distinguished between patients and controls with a sensitivity of 80% and a specificity of 85%. In patients the melatonin deficit was only significantly associated with insomnia. Impairments of melatonin synthesis in ASD may be linked with decreased 14-3-3 proteins. Although ASDs are highly heterogeneous, disruption of the serotonin-NAS-melatonin pathway is a very frequent trait in patients and may represent a useful biomarker for a large subgroup of individuals with ASD.
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| 5. |
- Egelhofer, Thea A, et al.
(författare)
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An assessment of histone-modification antibody quality
- 2011
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Ingår i: Nature Structural & Molecular Biology. - : Springer Science and Business Media LLC. - 1545-9993 .- 1545-9985. ; 18:1, s. 91-93
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Tidskriftsartikel (refereegranskat)abstract
- We have tested the specificity and utility of more than 200 antibodies raised against 57 different histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human cells. Although most antibodies performed well, more than 25% failed specificity tests by dot blot or western blot. Among specific antibodies, more than 20% failed in chromatin immunoprecipitation experiments. We advise rigorous testing of histone-modification antibodies before use, and we provide a website for posting new test results (http://compbio.med.harvard.edu/antibodies/).
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| 6. |
- Jouanny, I, et al.
(författare)
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In situ transmission electron microscopy studies of the kinetics of Pt-Mo alloy diffusion in ZrB2 thin films
- 2013
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Ingår i: Applied Physics Letters. - : American Institute of Physics (AIP). - 0003-6951 .- 1077-3118. ; 103:12
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Tidskriftsartikel (refereegranskat)abstract
- Using in situ high-temperature (1073–1173 K) transmission electron microscopy, we investigated the thermal stability of Pt and Mo in contact with polycrystalline ZrB2 thin films deposited on Al 2O3(0001). During annealing, we observed the diffusion of cubic-structured Pt1− x Mo x (with x = 0.2 ± 0.1) along the length of the ZrB2 layer. From the time-dependent increase in diffusion lengths, we determined that the Pt1− x Mo x does not react with ZrB2, but diffuses along the surface with a constant temperature-dependent velocity. We identify the rate-limiting step controlling the observed phenomenon as the flux of Mo atoms with an associated activation barrier of 3.8 ± 0.5 eV.
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| 7. |
- Kodambaka, S, et al.
(författare)
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Kinetics of Ga droplet decay on thin carbon films
- 2013
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Ingår i: Applied Physics Letters. - : American Institute of Physics (AIP). - 0003-6951 .- 1077-3118. ; 102:16
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Tidskriftsartikel (refereegranskat)abstract
- Using in situ transmission electron microscopy, we investigated the kinetics of liquid Ga droplet decay on thin amorphous carbon films during annealing at 773 K. The transmission electron microscopy images reveal that liquid Ga forms spherical droplets and undergo coarsening/decay with increasing time. We find that the droplet volumes change non-linearly with time and the volume decay rates depend on their local environment. By comparing the late-stage decay behavior of the droplets with the classical mean-field theory model for Ostwald ripening, we determine that the decay of Ga droplets occurs in the surface diffusion limited regime.
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| 8. |
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| 9. |
- Matthaiou, Michail, 1981, et al.
(författare)
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Analytic Framework for the Effective Rate of MISO Fading Channels
- 2012
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Ingår i: IEEE Transactions on Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 0090-6778 .- 1558-0857. ; 60:6, s. 1741-1751
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Tidskriftsartikel (refereegranskat)abstract
- The delay constraints imposed by future wireless applications require a suitable metric for assessing their impact on the overall system performance. Since the classical Shannon's ergodic capacity fails to do so, the so-called effective rate was recently established as a rigorous alternative. While prior relevant works have improved our knowledge on the effective rate characterization of communication systems, an analytical framework encompassing several fading models of interest is not yet available. In this paper, we pursue a detailed effective rate analysis of Nakagami-m, Rician and generalized-K multiple-input single-output (MISO) fading channels by deriving new, analytical expressions for their exact effective rate. Moreover, we consider the asymptotically low and high signal-to-noise regimes, for which tractable, closed-form effective rate expressions are presented. These results enable us to draw useful conclusions about the impact of system parameters on the effective rate of different MISO fading channels. All the theoretical expressions are validated via Monte-Carlo simulations.
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| 10. |
- Ngo, Hien, et al.
(författare)
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Multipair massive MIMO full-duplex relaying with MRC/MRT processing
- 2014
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Ingår i: 2014 IEEE International Conference on Communications, ICC 2014. - : IEEE Computer Society. - 9781479920037 ; , s. 4807-4813
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Konferensbidrag (refereegranskat)abstract
- We consider a multipair relay channel, where multiple sources communicate with multiple destinations with the help of a full-duplex (FD) relay station (RS). All sources and destinations have a single antenna, while the RS is equipped with massive arrays. We assume that the RS estimates the channels by using training sequences transmitted from sources and destinations. Then, it uses maximum-ratio combining/maximum-ratio transmission (MRC/MRT) to process the signals. To significantly reduce the loop interference (LI) effect, we propose two massive MIMO processing techniques: i) using a massive receive antenna array; or ii) using a massive transmit antenna array together with very low transmit power at the RS. We derive an exact achievable rate in closed-form and evaluate the system spectral efficiency. We show that, by doubling the number of antennas at the RS, the transmit power of each source and of the RS can be reduced by 1.5 dB if the pilot power is equal to the signal power and by 3 dB if the pilot power is kept fixed, while maintaining a given quality-of-service. Furthermore, we compare FD and half-duplex (HD) modes and show that FD improves significantly the performance when the LI level is low.
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