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- Pfaller, M.A., et al.
(author)
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Twelve years of fluconazole in clinical practice : Global-trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida
- 2004
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In: Clinical Microbiology and Infection. - : Elsevier BV. - 1198-743X .- 1469-0691. ; 10:SUPPL. 1, s. 11-23
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Journal article (peer-reviewed)abstract
- We determined the species distribution and in-vitro susceptibility of 6082 bloodstream infection (BSI) isolates of Candida spp. collected from 250 medical centres in 32 nations over a 10-year period from 1992 through 2001. The species included 3401 C. albicans, 984 C. glabrata, 796 C. parapsilosis, 585 C. tropicalis, 153 C. krusei, 67 C. lusitaniae, 48 C. guilliermondii, 10 C. famata, 10 C. kefyr, six C. pelliculosa, five C. rugosa, four C. lipolytica, three C. dubliniensis, three C. inconspicua, two C. sake and one isolate each of C. lambica, C. norvegensis and C. zeylanoides. Minimum inhibitory concentration determinations were made using the National Committee for Clinical Laboratory Standards reference broth microdilution method. Variation in the rank order and frequency of the different species of Candida was observed over time and by geographic area. The proportion of BSI due to C. albicans and C. glabrata increased and C. parapsilosis decreased over time in Canada, the USA and Europe. C. glabrata was an infrequent cause of BSI in Latin America and the Asia-Pacific region. Very little variation in fluconazole susceptibility was observed among isolates of C. albicans, C. tropicalis and C. parapsilosis. These species accounted for 78% of all BSI and remained highly susceptible (91-100% susceptible) to fluconazole from 1992 to 2001 irrespective of geographic origin. The prevalence of fluconazole resistance among C. glabrata isolates was variable both over time and among the various countries and regions. Resistance to fluconazole among C. glabrata isolates was greatest in the USA and varied by US census region (range 0-23%). These observations are generally encouraging relative to the sustained usefulness of fluconazole as a systemically active antifungal agent for the treatment of candida BSI. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.
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| 4. |
- Mantsinen, M. J., et al.
(author)
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Alpha-tail production with ion-cyclotron-resonance heating of He-4-beam ions in JET plasmas
- 2002
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 88:10
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Journal article (peer-reviewed)abstract
- Third-harmonic ion-cyclotron-resonance heating of He-4-beam ions has produced for the first time on the JET tokamak high-energy populations of He-4 ions to simulate 3.5 MeV fusion-born alpha (alpha) particles. Acceleration of He-4 ions to the MeV energy range is confirmed by gamma-ray emission from the nuclear reaction Be-9(alpha, ngamma) C-12 and excitation of Alfven eigenmodes. Concomitant electron heating and sawtooth stabilization are observed. The scheme could be used in next-step tokamaks to gain information on trapped alpha particles and to test a diagnostics in the early nonactivated phase of operation.
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| 5. |
- Mantsinen, M. J., et al.
(author)
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Analysis of ion cyclotron heating and current drive at omega approximate to 2 omega(cH) for sawtooth control in JET plasmas
- 2002
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In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 44:8, s. 1521-1542
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Journal article (peer-reviewed)abstract
- Ion cyclotron heating and current drive at omega approximate to 2omega(cH) in JET deuterium plasmas with a hydrogen concentration n(H)/(n(D)+n(H)) in the range of 5-15% are analysed, comparing results of numerical computer modelling with experiments. Second harmonic hydrogen damping is found to be maximized by placing the resonance on the, low-field side (LFS) of the torus, which minimizes competing direct electron damping and parasitic high-harmonic D damping in the presence of D beams. The shape of the calculated current perturbation and the radial localization of the heating power density for the LFS resonance are consistent with the experimentally observed evolution of the sawtooth period when the resonance layer moves near the q = 1 surface. Since the calculated driven current is dominated by a current of diamagnetic type caused by finite orbit widths of trapped resonating ions, it is not too sensitive to the ICRF phasing. Control of sawteeth with ion cyclotron current drive using the LFS omega approximate to 2omega(cH) resonance in the present experimental conditions can thus be best obtained by varying the resonance location rather than the ICRF phasing. Due to differences in fast ion orbits, collisional electron heating and fast ion pressure profiles are significantly more peaked for a LFS resonance than for a high-field side (HFS) resonance. For the HFS omega approximate to 2omega(cH) resonance, an enhanced neutron rate is observed in the presence of D beam ions, which is consistent with parasitic D damping at the omega approximate to 2omega(cD) resonance in the plasma centre.
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