| 1. |
- Pfaller, M.A., et al.
(författare)
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Twelve years of fluconazole in clinical practice : Global-trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida
- 2004
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Ingår i: Clinical Microbiology and Infection. - : Elsevier BV. - 1198-743X .- 1469-0691. ; 10:SUPPL. 1, s. 11-23
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Tidskriftsartikel (refereegranskat)abstract
- We determined the species distribution and in-vitro susceptibility of 6082 bloodstream infection (BSI) isolates of Candida spp. collected from 250 medical centres in 32 nations over a 10-year period from 1992 through 2001. The species included 3401 C. albicans, 984 C. glabrata, 796 C. parapsilosis, 585 C. tropicalis, 153 C. krusei, 67 C. lusitaniae, 48 C. guilliermondii, 10 C. famata, 10 C. kefyr, six C. pelliculosa, five C. rugosa, four C. lipolytica, three C. dubliniensis, three C. inconspicua, two C. sake and one isolate each of C. lambica, C. norvegensis and C. zeylanoides. Minimum inhibitory concentration determinations were made using the National Committee for Clinical Laboratory Standards reference broth microdilution method. Variation in the rank order and frequency of the different species of Candida was observed over time and by geographic area. The proportion of BSI due to C. albicans and C. glabrata increased and C. parapsilosis decreased over time in Canada, the USA and Europe. C. glabrata was an infrequent cause of BSI in Latin America and the Asia-Pacific region. Very little variation in fluconazole susceptibility was observed among isolates of C. albicans, C. tropicalis and C. parapsilosis. These species accounted for 78% of all BSI and remained highly susceptible (91-100% susceptible) to fluconazole from 1992 to 2001 irrespective of geographic origin. The prevalence of fluconazole resistance among C. glabrata isolates was variable both over time and among the various countries and regions. Resistance to fluconazole among C. glabrata isolates was greatest in the USA and varied by US census region (range 0-23%). These observations are generally encouraging relative to the sustained usefulness of fluconazole as a systemically active antifungal agent for the treatment of candida BSI. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.
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| 2. |
- Noterdaeme, J. M., et al.
(författare)
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Heating, current drive and energetic particle studies on JET in preparation of ITER operation
- 2003
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 43:3, s. 202-209
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Tidskriftsartikel (refereegranskat)abstract
- This paper summarizes the recent work on JET in the three areas of heating, current drive and energetic particles. The achievements have extended the possibilities of JET, have a direct connection to ITER operation and provide new and interesting physics. Toroidal rotation profiles of plasmas heated far off axis with little or no refuelling or momentum input are hollow with only small differences on whether the power deposition is located on the low field side or on the high field side. With LH current drive the magnetic shear was varied from slightly positive to negative. The improved coupling (through the use of plasma shaping and CD4) allowed up to 3.4 MW of PLH in internal transport barrier (ITB) plasmas with more than 15 MW of combined NBI and ICRF heating. The q-profile with negative magnetic shear and the ITB could be maintained for the duration of the high heating pulse (8 s). Fast ions have been produced in JET with ICRF to simulate alpha particles: by using third harmonic He-4 heating, beam injected He-4 at 120 kV were accelerated to energies above 2 MeV taking advantage of the unique capability of JET to use NBI with 4 He and to confine MeV class ions. ICRF heating was used to replicate the dynamics of alpha heating and the control of an equivalent Q = 10 `burn' was simulated.
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| 3. |
- Mantsinen, M. J., et al.
(författare)
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Localized bulk electron heating with ICRF mode conversion in the JET tokamak
- 2004
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 44:1, s. 33-46
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Tidskriftsartikel (refereegranskat)abstract
- Ion cyclotron resonance frequencies (ICRF) mode conversion has been developed for localized on-axis and off-axis bulk electron heating on the JET tokamak. The fast magnetosonic waves launched from the low-field side ICRF antennas are mode-converted to short-wavelength waves on the high-field side of the He-3 ion cyclotron resonance layer in D and He-4 plasmas and subsequently damped on the bulk electrons. The resulting electron power deposition, measured using ICRF power modulation, is narrow with a typical full-width at half-maximum of approximate to30 cm (i.e. about 30% of the minor radius) and the total deposited power to electrons comprises at least up to 80% of the applied ICRF power. The ICRF mode conversion power deposition has been kept constant using He-3 bleed throughout the ICRF phase with a typical duration of 4-6 s, i.e. 15-40 energy confinement times. Using waves propagating in the counter-current direction minimizes competing ion damping in the presence of co-injected deuterium beam ions.
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| 4. |
- Sauter, O., et al.
(författare)
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Control of neoclassical tearing modes by sawtooth control
- 2002
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 88:10
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Tidskriftsartikel (refereegranskat)abstract
- The onset of a neoclassical tearing mode (NTM) depends on the existence of a large enough seed island. It is shown in the Joint European Torus that NTMs can be readily destabilized by long-period sawteeth, such as obtained by sawtooth stabilization from ion-cyclotron heating or current drive. This has important implications for burning plasma scenarios, as alpha particles strongly stabilize the sawteeth. It is also shown that, by adding heating and current drive just outside the inversion radius, sawteeth are destabilized, resulting in shorter sawtooth periods and larger beta values being obtained without NTMs.
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| 5. |
- Westerhof, E., et al.
(författare)
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Control of sawteeth and triggering of NTMs with ion cyclotron resonance frequency waves in JET
- 2002
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 42:11, s. 1324-1334
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Tidskriftsartikel (refereegranskat)abstract
- A new scenario to delay or prevent neoclassical tearing mode (NTM) onset is presented. By active sawtooth destabilization, short period and low amplitude sawteeth are generated, such that the sawtooth produced NTM seed island is reduced and the threshold normalized plasma pressure for triggering of NTMs, beta(Nonset), is increased. The scenario has been explored experimentally in the Joint European Torus (JET). Ion cyclotron resonance frequency (ICRF) waves tuned to the 2nd harmonic H-minority resonance have been used for sawtooth control. Whereas ICRF waves generally induce sawtooth stabilization, favouring the triggering of NTMs and reducing beta(Nonset), the present experiments show that by toroidally directed waves, ion cyclotron current drive is produced, and that sawteeth can be destabilized by careful positioning of the 2nd harmonic H resonance layer with respect to the sawtooth inversion radius. As a result, NTM onset is delayed and beta(Nonset) is increased above its value obtained in discharges with additional heating from neutral beam injection alone.
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| 6. |
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| 7. |
- Mantsinen, M. J., et al.
(författare)
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Analysis of ion cyclotron heating and current drive at omega approximate to 2 omega(cH) for sawtooth control in JET plasmas
- 2002
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 44:8, s. 1521-1542
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Tidskriftsartikel (refereegranskat)abstract
- Ion cyclotron heating and current drive at omega approximate to 2omega(cH) in JET deuterium plasmas with a hydrogen concentration n(H)/(n(D)+n(H)) in the range of 5-15% are analysed, comparing results of numerical computer modelling with experiments. Second harmonic hydrogen damping is found to be maximized by placing the resonance on the, low-field side (LFS) of the torus, which minimizes competing direct electron damping and parasitic high-harmonic D damping in the presence of D beams. The shape of the calculated current perturbation and the radial localization of the heating power density for the LFS resonance are consistent with the experimentally observed evolution of the sawtooth period when the resonance layer moves near the q = 1 surface. Since the calculated driven current is dominated by a current of diamagnetic type caused by finite orbit widths of trapped resonating ions, it is not too sensitive to the ICRF phasing. Control of sawteeth with ion cyclotron current drive using the LFS omega approximate to 2omega(cH) resonance in the present experimental conditions can thus be best obtained by varying the resonance location rather than the ICRF phasing. Due to differences in fast ion orbits, collisional electron heating and fast ion pressure profiles are significantly more peaked for a LFS resonance than for a high-field side (HFS) resonance. For the HFS omega approximate to 2omega(cH) resonance, an enhanced neutron rate is observed in the presence of D beam ions, which is consistent with parasitic D damping at the omega approximate to 2omega(cD) resonance in the plasma centre.
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| 8. |
- Mantsinen, M. J., et al.
(författare)
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Alpha-tail production with ion-cyclotron-resonance heating of He-4-beam ions in JET plasmas
- 2002
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 88:10
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Tidskriftsartikel (refereegranskat)abstract
- Third-harmonic ion-cyclotron-resonance heating of He-4-beam ions has produced for the first time on the JET tokamak high-energy populations of He-4 ions to simulate 3.5 MeV fusion-born alpha (alpha) particles. Acceleration of He-4 ions to the MeV energy range is confirmed by gamma-ray emission from the nuclear reaction Be-9(alpha, ngamma) C-12 and excitation of Alfven eigenmodes. Concomitant electron heating and sawtooth stabilization are observed. The scheme could be used in next-step tokamaks to gain information on trapped alpha particles and to test a diagnostics in the early nonactivated phase of operation.
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| 9. |
- Millard, A., et al.
(författare)
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Evaluation of Thm Coupling on the Safety Assessment of a Nuclear Fuel Waste Repository in a Homogeneous Hard Rock
- 2004
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Ingår i: Coupled Thermo-Hydro-Mechanical-Chemical Processes in Geo-Systems — Fundamentals, Modelling, Experiments and Applications. - : Elsevier. ; , s. 211-216
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Bokkapitel (refereegranskat)abstract
- An evaluation of the importance of the thermo-hydro-mechanical couplings (THM) on the performance assessment of a deep underground storage design has been made as part of the international DECOVALEX III project. It is a numerical study that simulates a generic repository configuration in the near field in a homogeneous hard rock. A periodic pattern comprises a single vertical borehole, containing a canister surrounded by an over-pack and a bentonite layer, and the backfilled upper portion of the gallery. The thermo-hydro-mechanical evolution of the whole configuration is simulated over a period of 100 years. The importance of the rock mass intrinsic permeability has been investigated through three values : 10 -17, 10 -18 and 10 -19 m 2. Comparison of the results predicted by fully coupled THM analysis as well as partially coupled TH, TM and HM analysis, in terms of several predefined indicators, enables us to identify the couplings, which play a crucial role with respect to safety issues. The results demonstrate that temperature is hardly affected by the couplings. In contrast the influence of the couplings on the mechanical stresses is considerable.
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| 10. |
- Nguyen, T. S., et al.
(författare)
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Hydro-mechanical response of a fractured granitic rock mass to excavation of a test pit - the Kamaishi Mine experiment in Japan
- 2001
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - 1365-1609 .- 1873-4545. ; 38:1, s. 79-94
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Tidskriftsartikel (refereegranskat)abstract
- A thermo-hydro-mechanical experiment was conducted in a fractured granitic ruck mass at the Kamaishi Mine in Japan. The experiment consists of the excavation of a cylindrical test pit on the floor of an experimental drift. The test pit was then lilted with bentonite with an embedded heater. During the excavation of the test pit, the hydromechanical response of the surrounding rock was monitored. This paper presents the efforts of four research teams to numerically simulate the hydro-mechanical response of the rock mass during excavation. While the total inflow rate to the test pit, the flow distribution on the pit walls and the displacements in the rock mass away From the pit could be reasonably predicted, the pore pressure in individual boreholes, and the expansion behaviour of the pit were less successfully simulated. The reasons for these discrepancies are discussed in the paper.
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